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ONTOLOGY REPORT - ANNOTATIONS


Term:cardiac endothelial to mesenchymal transition
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Accession:GO:0140074 term browser browse the term
Definition:A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cells necessary for proper heart development. EndMT, specifically generates valve progenitor cells that give rise to the mitral and tricuspid valves. EndMT also contributes to endocardial cushion formation, as well as to generation of cardiac fibroblasts and smooth muscle cells, but not cardiac myocytes.
Synonyms:exact_synonym: EndMT;   EndoMT



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cardiac endothelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SEMA3C semaphorin 3C involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 7:80,742,538...80,922,389
Ensembl chr 7:80,742,538...80,922,359
JBrowse link
positive regulation of cardiac endothelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA5 GATA binding protein 5 involved_in ISS
IEA
BHF-UCL
BHF-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr20:62,463,497...62,475,995
Ensembl chr20:62,463,497...62,475,995
JBrowse link
G MIR342 microRNA 342 involved_in IDA (PMID:26857067) BHF-UCL PMID:26857067 NCBI chr14:100,109,655...100,109,753
Ensembl chr14:100,109,655...100,109,753
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19656
    cellular process 18146
      cellular developmental process 4995
        cell differentiation 4972
          mesenchymal cell differentiation 271
            cardiac endothelial to mesenchymal transition 3
              negative regulation of cardiac endothelial to mesenchymal transition 0
              positive regulation of cardiac endothelial to mesenchymal transition 2
              regulation of cardiac endothelial to mesenchymal transition + 2
Path 2
Term Annotations click to browse term
  biological_process 19656
    developmental process 7515
      anatomical structure development 6875
        tissue development 2394
          mesenchyme development 341
            mesenchymal cell differentiation 271
              cardiac endothelial to mesenchymal transition 3
                negative regulation of cardiac endothelial to mesenchymal transition 0
                positive regulation of cardiac endothelial to mesenchymal transition 2
                regulation of cardiac endothelial to mesenchymal transition + 2
paths to the root