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ONTOLOGY REPORT - ANNOTATIONS


Term:cardiac endothelial to mesenchymal transition
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Accession:GO:0140074 term browser browse the term
Definition:A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cells necessary for proper heart development. EndMT, specifically generates valve progenitor cells that give rise to the mitral and tricuspid valves. EndMT also contributes to endocardial cushion formation, as well as to generation of cardiac fibroblasts and smooth muscle cells, but not cardiac myocytes.
Synonyms:exact_synonym: EndMT;   EndoMT



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cardiac endothelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SEMA3C semaphorin 3C involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr18:20,457,683...20,748,008
Ensembl chr18:20,459,925...20,635,276
JBrowse link
positive regulation of cardiac endothelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GATA5 GATA binding protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:46,417,404...46,427,617
Ensembl chr24:46,417,391...46,429,858
JBrowse link
G MIR342 microRNA mir-342 involved_in ISO (PMID:26857067) BHF-UCL PMID:26857067 NCBI chr 8:68,424,656...68,424,718 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16442
    cellular process 15494
      cellular developmental process 4314
        cell differentiation 4291
          mesenchymal cell differentiation 258
            cardiac endothelial to mesenchymal transition 3
              negative regulation of cardiac endothelial to mesenchymal transition 0
              positive regulation of cardiac endothelial to mesenchymal transition 2
              regulation of cardiac endothelial to mesenchymal transition + 2
Path 2
Term Annotations click to browse term
  biological_process 16442
    developmental process 6558
      anatomical structure development 6130
        tissue development 2119
          mesenchyme development 317
            mesenchymal cell differentiation 258
              cardiac endothelial to mesenchymal transition 3
                negative regulation of cardiac endothelial to mesenchymal transition 0
                positive regulation of cardiac endothelial to mesenchymal transition 2
                regulation of cardiac endothelial to mesenchymal transition + 2
paths to the root