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ONTOLOGY REPORT - ANNOTATIONS


Term:cardiac endothelial to mesenchymal transition
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Accession:GO:0140074 term browser browse the term
Definition:A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cells necessary for proper heart development. EndMT, specifically generates valve progenitor cells that give rise to the mitral and tricuspid valves. EndMT also contributes to endocardial cushion formation, as well as to generation of cardiac fibroblasts and smooth muscle cells, but not cardiac myocytes.
Synonyms:exact_synonym: EndMT;   EndoMT


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cardiac endothelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sema3c semaphorin 3C involved_in ISO (MGI:5693177|PMID:26053665) BHF-UCL PMID:26053665 MGI:5693177 NCBI chrNW_004955410:4,795,658...4,953,460
Ensembl chrNW_004955410:4,794,477...4,954,906
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positive regulation of cardiac endothelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata5 GATA binding protein 5 involved_in ISO (MGI:5286818|PMID:21633169) BHF-UCL PMID:21633169 MGI:5286818 NCBI chrNW_004955528:1,595,231...1,604,979
Ensembl chrNW_004955528:1,595,231...1,604,979
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Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12182
    cellular process 11320
      cellular developmental process 3738
        cell differentiation 3716
          mesenchymal cell differentiation 216
            cardiac endothelial to mesenchymal transition 2
              negative regulation of cardiac endothelial to mesenchymal transition 0
              positive regulation of cardiac endothelial to mesenchymal transition 1
              regulation of cardiac endothelial to mesenchymal transition + 1
Path 2
Term Annotations click to browse term
  biological_process 12182
    developmental process 5761
      anatomical structure development 5413
        tissue development 1893
          mesenchyme development 267
            mesenchymal cell differentiation 216
              cardiac endothelial to mesenchymal transition 2
                negative regulation of cardiac endothelial to mesenchymal transition 0
                positive regulation of cardiac endothelial to mesenchymal transition 1
                regulation of cardiac endothelial to mesenchymal transition + 1
paths to the root