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ONTOLOGY REPORT - ANNOTATIONS


Term:cardiac endothelial to mesenchymal transition
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Accession:GO:0140074 term browser browse the term
Definition:A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cells necessary for proper heart development. EndMT, specifically generates valve progenitor cells that give rise to the mitral and tricuspid valves. EndMT also contributes to endocardial cushion formation, as well as to generation of cardiac fibroblasts and smooth muscle cells, but not cardiac myocytes.
Synonyms:exact_synonym: EndMT;   EndoMT



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cardiac endothelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SEMA3C semaphorin 3C involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:72,706,615...72,884,163
Ensembl chr 7:86,368,753...86,545,580
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Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15332
    cellular process 14173
      cellular developmental process 3993
        cell differentiation 3970
          mesenchymal cell differentiation 223
            cardiac endothelial to mesenchymal transition 1
              negative regulation of cardiac endothelial to mesenchymal transition 0
              positive regulation of cardiac endothelial to mesenchymal transition 0
              regulation of cardiac endothelial to mesenchymal transition + 0
Path 2
Term Annotations click to browse term
  biological_process 15332
    developmental process 6158
      anatomical structure development 5749
        tissue development 1994
          mesenchyme development 277
            mesenchymal cell differentiation 223
              cardiac endothelial to mesenchymal transition 1
                negative regulation of cardiac endothelial to mesenchymal transition 0
                positive regulation of cardiac endothelial to mesenchymal transition 0
                regulation of cardiac endothelial to mesenchymal transition + 0
paths to the root