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ONTOLOGY REPORT - ANNOTATIONS


Term:cardiac endothelial to mesenchymal transition
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Accession:GO:0140074 term browser browse the term
Definition:A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cells necessary for proper heart development. EndMT, specifically generates valve progenitor cells that give rise to the mitral and tricuspid valves. EndMT also contributes to endocardial cushion formation, as well as to generation of cardiac fibroblasts and smooth muscle cells, but not cardiac myocytes.
Synonyms:exact_synonym: EndMT;   EndoMT



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cardiac endothelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sema3c semaphorin 3C involved_in ISO (MGI:5693177|PMID:26053665) RGD PMID:26053665 MGI:5693177 NCBI chr 4:17,583,212...17,747,234
Ensembl chr 4:17,583,212...17,746,534
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positive regulation of cardiac endothelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata5 GATA binding protein 5 involved_in ISO (MGI:5286818|PMID:21633169) RGD PMID:21633169 MGI:5286818 NCBI chr 3:167,418,563...167,426,751
Ensembl chr 3:167,418,565...167,426,751
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Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19512
    cellular process 18319
      cellular developmental process 4585
        cell differentiation 4489
          mesenchymal cell differentiation 242
            cardiac endothelial to mesenchymal transition 2
              negative regulation of cardiac endothelial to mesenchymal transition 0
              positive regulation of cardiac endothelial to mesenchymal transition 1
              regulation of cardiac endothelial to mesenchymal transition + 1
Path 2
Term Annotations click to browse term
  biological_process 19512
    developmental process 6931
      anatomical structure development 6346
        multicellular organism development 5773
          system development 5413
            animal organ development 4174
              mesenchyme development 302
                mesenchymal cell differentiation 242
                  cardiac endothelial to mesenchymal transition 2
                    negative regulation of cardiac endothelial to mesenchymal transition 0
                    positive regulation of cardiac endothelial to mesenchymal transition 1
                    regulation of cardiac endothelial to mesenchymal transition + 1
paths to the root