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ONTOLOGY REPORT - ANNOTATIONS

Term:tight junction organization
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Accession:GO:0120193 term browser browse the term
Definition:A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other.
Synonyms:exact_synonym: occluding cell junction organization;   occluding junction organization


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tight junction organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN18 claudin 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:135,037,555...135,061,105
Ensembl chr 3:142,478,031...142,512,548 		JBrowse link
G CLDN19 claudin 19 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15883201) Ensembl
MGI		 PMID:15883201 GO_REF:0000107 NCBI chr 1:42,032,999...42,040,006
Ensembl chr 1:43,408,876...43,417,448 		JBrowse link
G CLDN9 claudin 9 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17130295) Ensembl
MGI		 PMID:17130295 GO_REF:0000107 NCBI chr16:1,953,439...1,956,349
Ensembl chr16:3,127,610...3,128,263 		JBrowse link
G EXT1 exostosin glycosyltransferase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26024086) Ensembl
MGI		 PMID:26024086 GO_REF:0000107 NCBI chr 8:114,489,325...114,803,763
Ensembl chr 8:117,011,919...117,324,851 		JBrowse link
G OCLN occludin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:44,447,230...44,509,637
Ensembl chr 5:46,023,437...46,069,342 		JBrowse link
G PLEC plectin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:140,681,252...140,742,753
Ensembl chr 8:143,674,696...143,712,433 		JBrowse link
G SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:28179432) Ensembl
MGI		 PMID:28179432 GO_REF:0000107 NCBI chr 9:81,521,495...81,727,869
Ensembl chr 9:109,686,826...109,892,291 		JBrowse link
bicellular tight junction assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTN4 actinin alpha 4 involved_in ISO (MGI:3794927|PMID:18332111) UniProt PMID:18332111 MGI:3794927 NCBI chr19:35,742,758...35,825,321
Ensembl chr19:44,313,569...44,395,508 		JBrowse link
G AFDN afadin, adherens junction formation factor involved_in ISO (PMID:27815408) ARUK-UCL PMID:27815408 NCBI chr 6:165,778,026...165,923,685
Ensembl chr 6:170,775,904...170,882,784 		JBrowse link
G ALOX12B arachidonate 12-lipoxygenase, 12R type NOT|involved_in ISO (MGI:3789553|PMID:17403930) UniProt PMID:17403930 MGI:3789553 NCBI chr17:43,569,858...43,588,039
Ensembl chr17:48,302,450...48,317,029 		JBrowse link
G ALOXE3 arachidonate lipoxygenase 3 NOT|involved_in ISO (MGI:5488571|PMID:22832496) UniProt PMID:22832496 MGI:5488571 NCBI chr17:43,539,657...43,562,433
Ensembl chr17:48,271,226...48,293,941 		JBrowse link
G CDH1 cadherin 1 acts_upstream_of_or_within ISO (PMID:15775979) MGI PMID:15775979 NCBI chr16:49,108,745...49,206,347
Ensembl chr16:68,502,584...68,596,488 		JBrowse link
G CDH5 cadherin 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:46,684,545...46,722,740
Ensembl chr16:65,787,370...65,825,360 		JBrowse link
G CGN cingulin acts_upstream_of_or_within ISO (PMID:24385485) MGI PMID:24385485 NCBI chr 1:126,869,973...126,897,024 JBrowse link
G CLDN1 claudin 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:187,328,629...187,345,360
Ensembl chr 3:195,882,239...195,899,248 		JBrowse link
G CLDN10 claudin 10 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr13:76,728,572...76,755,685
Ensembl chr13:95,763,980...95,909,161 		JBrowse link
G CLDN11 claudin 11 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 3:167,432,856...167,448,053
Ensembl chr 3:175,621,472...175,908,350 		JBrowse link
G CLDN14 claudin 14 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr21:22,830,770...22,946,594
Ensembl chr21:36,187,306...36,188,025 		JBrowse link
G CLDN15 claudin 15 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 7:93,373,450...93,380,912
Ensembl chr 7:106,613,604...106,620,479 		JBrowse link
G CLDN16 claudin 16 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 3:187,141,710...187,436,909
Ensembl chr 3:195,964,178...195,990,065 		JBrowse link
G CLDN17 claudin 17 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr21:16,585,223...16,586,444
Ensembl chr21:29,968,865...29,969,539 		JBrowse link
G CLDN18 claudin 18 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 3:135,037,555...135,061,105
Ensembl chr 3:142,478,031...142,512,548 		JBrowse link
G CLDN19 claudin 19 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:42,032,999...42,040,006
Ensembl chr 1:43,408,876...43,417,448 		JBrowse link
G CLDN2 claudin 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr  X:96,020,274...96,031,157
Ensembl chr  X:106,405,879...106,406,571 		JBrowse link
G CLDN20 claudin 20 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:153,089,106...153,093,580
Ensembl chr 6:159,056,863...159,057,522 		JBrowse link
G CLDN23 claudin 23 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:10,510,323...10,512,467 JBrowse link
G CLDN25 claudin 25 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:108,658,470...108,659,159
Ensembl chr11:112,500,922...112,501,611 		JBrowse link
G CLDN3 claudin 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 Ensembl chr 7:80,924,731...80,925,393 JBrowse link
G CLDN34 claudin 34 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr  X:2,591,451...2,599,328
Ensembl chr  X:9,850,227...9,850,871 		JBrowse link
G CLDN4 claudin 4 involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr 7:80,983,832...80,984,461 JBrowse link
G CLDN5 claudin 5 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr22:2,282,215...2,286,724
Ensembl chr22:17,958,182...17,959,093 		JBrowse link
G CLDN7 claudin 7 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:7,289,766...7,292,433
Ensembl chr17:7,277,313...7,281,859 		JBrowse link
G CLDN8 claudin 8 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr21:16,634,733...16,636,809
Ensembl chr21:30,020,274...30,020,951 		JBrowse link
G CLDN9 claudin 9 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr16:1,953,439...1,956,349
Ensembl chr16:3,127,610...3,128,263 		JBrowse link
G CTNNB1 catenin beta 1 involved_in ISO (PMID:8636221) UniProt PMID:8636221 NCBI chr 3:41,104,940...41,145,934
Ensembl chr 3:41,373,726...41,414,030 		JBrowse link
G DLG1 discs large MAGUK scaffold protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:194,386,263...194,648,015
Ensembl chr 3:204,323,724...204,584,987 		JBrowse link
G ECT2 epithelial cell transforming 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:169,756,885...169,828,087
Ensembl chr 3:177,938,164...178,008,381 		JBrowse link
G ESAM endothelial cell adhesion molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:119,580,140...119,589,338
Ensembl chr11:123,495,779...123,504,938 		JBrowse link
G FRMPD2 FERM and PDZ domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:45,968,125...46,094,690 JBrowse link
G GRHL2 grainyhead like transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:98,129,147...98,308,120
Ensembl chr 8:100,308,575...100,471,830 		JBrowse link
G ITGB1 integrin subunit beta 1 ISO RGD PMID:18579774 RGD:2325293 NCBI chr10:33,023,573...33,081,384
Ensembl chr10:33,608,978...33,644,031 		JBrowse link
G LOC103786942 claudin-22 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 4:175,494,516...175,496,676 JBrowse link
G MARVELD2 MARVEL domain containing 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:44,557,385...44,585,868
Ensembl chr 5:46,128,408...46,155,981 		JBrowse link
G MARVELD3 MARVEL domain containing 3 involved_in ISO (PMID:20164257) UniProt PMID:20164257 NCBI chr16:53,369,080...53,385,031
Ensembl chr16:71,463,824...71,477,631 		JBrowse link
G MICALL2 MICAL like 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:1,676,677...1,708,475
Ensembl chr 7:1,801,760...1,827,258 		JBrowse link
G MPP7 MAGUK p55 scaffold protein 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:28,202,057...28,453,950
Ensembl chr10:28,560,859...28,764,212 		JBrowse link
G MTDH metadherin ISO RGD PMID:15383321 RGD:1359738 NCBI chr 8:94,282,432...94,368,516
Ensembl chr 8:96,473,247...96,551,341 		JBrowse link
G OCEL1 occludin/ELL domain containing 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:16,713,136...16,716,252
Ensembl chr19:17,687,441...17,690,447 		JBrowse link
G OCLN occludin involved_in IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:44,447,230...44,509,637
Ensembl chr 5:46,023,437...46,069,342 		JBrowse link
G PAK2 p21 (RAC1) activated kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:194,084,037...194,174,010
Ensembl chr 3:204,023,357...204,111,507 		JBrowse link
G PARD3 par-3 family cell polarity regulator involved_in ISO PMID:18082612 UniProt PMID:18082612 RGD:8553352 NCBI chr10:34,225,791...34,933,907
Ensembl chr10:34,808,380...35,393,287 		JBrowse link
G PDCD6IP programmed cell death 6 interacting protein involved_in ISO (MGI:5819325|PMID:27336173) UniProt PMID:27336173 MGI:5819325 NCBI chr 3:33,719,603...33,793,301
Ensembl chr 3:34,016,474...34,093,631 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:58,417,134...58,526,409
Ensembl chr17:63,511,784...63,579,067 		JBrowse link
G POF1B POF1B actin binding protein involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:74,347,322...74,444,182
Ensembl chr  X:84,457,716...84,554,627 		JBrowse link
G RAB13 RAB13, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:129,338,524...129,343,234
Ensembl chr 1:132,967,363...132,972,067 		JBrowse link
G RAMP2 receptor activity modifying protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:14,554,888...14,557,175
Ensembl chr17:14,779,666...14,781,481 		JBrowse link
G SLC39A9 solute carrier family 39 member 9 involved_in ISO PMID:35625396
PMID:27164415		 UniProt PMID:27164415 PMID:35625396 RGD:155663535 RGD:155663545 NCBI chr14:49,990,089...50,056,782
Ensembl chr14:68,863,770...68,929,863 		JBrowse link
G SRF serum response factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20047077) Ensembl
MGI		 PMID:20047077 GO_REF:0000107 NCBI chr 6:42,763,099...42,773,332
Ensembl chr 6:44,057,192...44,066,768 		JBrowse link
G TBCD tubulin folding cofactor D involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:77,170,966...77,371,078
Ensembl chr17:82,971,613...83,158,223 		JBrowse link
G TJP1 tight junction protein 1 involved_in ISO (PMID:8636221) UniProt PMID:8636221 NCBI chr15:981,198...1,249,292
Ensembl chr15:26,344,878...26,598,878 		JBrowse link
G WNT11 Wnt family member 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17767158) Ensembl
MGI		 PMID:17767158 GO_REF:0000107 NCBI chr11:71,239,781...71,263,915
Ensembl chr11:74,540,169...74,560,024 		JBrowse link
negative regulation of bicellular tight junction assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:41,515,613...41,576,229
Ensembl chr 8:38,960,594...39,020,971 		JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:14,192,293...14,352,357
Ensembl chr18:17,833,047...17,990,086 		JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:11,167,353...11,331,339
Ensembl chr2A:11,318,370...11,478,986 		JBrowse link
G RPS6 ribosomal protein S6 ISO RGD PMID:25217631 RGD:11041641 NCBI chr 9:19,185,455...19,189,504
Ensembl chr 9:19,674,380...19,677,722 		JBrowse link
G TNF tumor necrosis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
positive regulation of bicellular tight junction assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACVRL1 activin A receptor like type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:36,839,869...36,856,351
Ensembl chr12:37,615,888...37,631,691 		JBrowse link
G CLDN1 claudin 1 ISO RGD PMID:22684624 RGD:11341733 NCBI chr 3:187,328,629...187,345,360
Ensembl chr 3:195,882,239...195,899,248 		JBrowse link
G CLDN3 claudin 3 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 7:80,924,731...80,925,393 JBrowse link
G CLDN5 claudin 5 involved_in ISO (PMID:25323998) ARUK-UCL PMID:25323998 NCBI chr22:2,282,215...2,286,724
Ensembl chr22:17,958,182...17,959,093 		JBrowse link
G EPHA2 EPH receptor A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:15,259,915...15,292,983
Ensembl chr 1:16,253,513...16,284,787 		JBrowse link
G GCG glucagon involved_in ISO (PMID:25050009) AgBase PMID:25050009 NCBI chr2B:49,436,379...49,446,559
Ensembl chr2B:166,806,016...166,811,155 		JBrowse link
G GDF2 growth differentiation factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:46,520,808...46,526,414 JBrowse link
G IL17A interleukin 17A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:51,736,269...51,740,538
Ensembl chr 6:53,004,820...53,009,074 		JBrowse link
G NPHP1 nephrocystin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:91,520,612...91,602,187
Ensembl chr2A:111,625,267...111,706,205 		JBrowse link
G NPHP4 nephrocystin 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:4,620,593...4,756,363
Ensembl chr 1:5,878,739...6,012,864 		JBrowse link
positive regulation of tight junction disassembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 ISO RGD PMID:23633925 RGD:12791991 NCBI chr11:17,447,564...17,531,513
Ensembl chr11:17,133,063...17,216,870 		JBrowse link
G TGFB3 transforming growth factor beta 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:56,516,697...56,542,097
Ensembl chr14:75,359,505...75,382,412 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:70,195,007...70,243,514
Ensembl chr 9:98,332,739...98,362,748 		JBrowse link
regulation of bicellular tight junction assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F11R F11 receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:136,399,766...136,424,722
Ensembl chr 1:140,324,943...140,346,890 		JBrowse link
G FZD5 frizzled class receptor 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23610556) Ensembl
MGI		 PMID:23610556 GO_REF:0000107 NCBI chr2B:95,003,246...95,010,577
Ensembl chr2B:213,133,017...213,134,774 		JBrowse link
G GJA1 gap junction protein alpha 1 ISO RGD PMID:19509333 RGD:6784505 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G GPBAR1 G protein-coupled bile acid receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:105,520,364...105,523,229
Ensembl chr2B:224,120,127...224,121,119 		JBrowse link
G MYO1C myosin IC involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:1,446,506...1,475,634
Ensembl chr17:1,345,143...1,375,540 		JBrowse link
G NEDD4L NEDD4 like E3 ubiquitin protein ligase acts_upstream_of_or_within ISO (PMID:20504882) MGI PMID:20504882 NCBI chr18:51,428,077...51,792,995
Ensembl chr18:54,867,149...55,123,423 		JBrowse link
G PKP2 plakophilin 2 ISO RGD PMID:19509333 RGD:6784505 NCBI chr12:53,322,227...53,428,747
Ensembl chr12:55,925,174...56,030,998 		JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:13,657,344...13,683,864
Ensembl chr19:14,385,191...14,406,205 		JBrowse link
G PRKCH protein kinase C eta involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:41,882,022...42,151,305
Ensembl chr14:60,179,081...60,408,251 		JBrowse link
G SNAI1 snail family transcriptional repressor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:46,321,075...46,328,865
Ensembl chr20:47,384,818...47,390,733 		JBrowse link
G SNAI2 snail family transcriptional repressor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:45,341,857...45,345,544
Ensembl chr 8:42,723,971...42,730,904 		JBrowse link
G TJP1 tight junction protein 1 involved_in ISO (PMID:25753039) ARUK-UCL PMID:25753039 NCBI chr15:981,198...1,249,292
Ensembl chr15:26,344,878...26,598,878 		JBrowse link
tight junction assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTG1 actin gamma 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:75,965,911...75,968,822
Ensembl chr17:81,668,221...81,671,087 		JBrowse link
G CLDN11 claudin 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:167,432,856...167,448,053
Ensembl chr 3:175,621,472...175,908,350 		JBrowse link
G CLDN12 claudin 12 NOT|involved_in ISO (MGI:6368067|PMID:31511021) ARUK-UCL PMID:31511021 MGI:6368067 NCBI chr 7:82,417,687...82,430,167 JBrowse link
G CLDN18 claudin 18 involved_in ISO (MGI:6449952|PMID:22079592) UniProt PMID:22079592 MGI:6449952 NCBI chr 3:135,037,555...135,061,105
Ensembl chr 3:142,478,031...142,512,548 		JBrowse link
G CLDN5 claudin 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:2,282,215...2,286,724
Ensembl chr22:17,958,182...17,959,093 		JBrowse link
G EPHB2 EPH receptor B2 ISO RGD PMID:33722292 RGD:127285641 NCBI chr 1:21,895,961...22,107,649
Ensembl chr 1:22,912,570...23,047,118 		JBrowse link
G MPDZ multiple PDZ domain crumbs cell polarity complex component involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:12,943,252...13,120,126
Ensembl chr 9:13,391,903...13,535,292 		JBrowse link
G PATJ PATJ crumbs cell polarity complex component involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:60,993,316...61,416,043
Ensembl chr 1:62,832,424...63,247,074 		JBrowse link
tricellular tight junction assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ILDR1 immunoglobulin like domain containing receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:119,088,855...119,124,831
Ensembl chr 3:125,996,018...126,032,041 		JBrowse link
G LSR lipolysis stimulated lipoprotein receptor involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr19:32,195,036...32,214,300
Ensembl chr19:40,932,180...40,951,448 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16313
    cellular process 15397
      cellular component organization or biogenesis 6593
        cellular component organization 6372
          cell junction organization 899
            cell-cell junction organization 234
              tight junction organization 90
                tight junction assembly + 84
                tight junction disassembly + 3
paths to the root