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ONTOLOGY REPORT - ANNOTATIONS


Term:steroid hormone biosynthetic process
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Accession:GO:0120178 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.


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aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in ISO (PMID:19342457) UniProt PMID:19342457 RGD:4891166 NCBI chrNW_004936694:2,702,224...2,724,574 JBrowse link
G LOC101968373 cytochrome P450 11B3, mitochondrial-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936470:9,034,177...9,039,486 JBrowse link
androgen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b2 hydroxysteroid 17-beta dehydrogenase 2 ISO androstenedione RGD PMID:8612487 RGD:728619 NCBI chrNW_004936475:29,426,922...29,494,215
Ensembl chrNW_004936475:29,426,883...29,494,225
JBrowse link
G Med1 mediator complex subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:14,625,201...14,663,184
Ensembl chrNW_004936490:14,625,897...14,657,802
JBrowse link
G Scarb1 scavenger receptor class B member 1 ISO RGD PMID:12746305 RGD:1304382 NCBI chrNW_004936558:530,828...555,098
Ensembl chrNW_004936558:530,828...552,892
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 acts_upstream_of_or_within ISO dihydrotestosterone
(PMID:15249131)
RGD
MGI
PMID:12606426 PMID:15249131 RGD:4891962 NCBI chrNW_004936634:758,231...798,809 JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 acts_upstream_of_or_within
involved_in
ISO
IEA
dihydrotestosterone
(PMID:15249131)
RGD
MGI
UniProt
Ensembl
PMID:12606426 PMID:15249131 GO_REF:0000107 GO_REF:0000117 RGD:4891962 NCBI chrNW_004936493:1,663,999...1,708,530
Ensembl chrNW_004936493:1,663,911...1,708,502
JBrowse link
C21-steroid hormone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101957714 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936514:1,467,460...1,480,185
Ensembl chrNW_004936514:1,467,261...1,480,185
JBrowse link
G LOC101963150 sterol 26-hydroxylase, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936569:1,213,700...1,250,181
Ensembl chrNW_004936569:1,213,573...1,250,589
JBrowse link
G LOC101975820 cholesterol side-chain cleavage enzyme, mitochondrial acts_upstream_of_or_within
involved_in
ISO
IEA
pregnenolone
(PMID:7527351)
RGD
MGI
TreeGrafter
Ensembl
PMID:7527351 PMID:19665544 GO_REF:0000107 GO_REF:0000118 RGD:4891164 NCBI chrNW_004936471:33,367,810...33,380,764
Ensembl chrNW_004936471:33,367,810...33,380,764
JBrowse link
G LOC101978323 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936646:1,899,686...1,904,104
Ensembl chrNW_004936646:1,900,259...1,904,104
JBrowse link
cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in ISO PMID:19342457
(PMID:19342457)
UniProt PMID:19342457 RGD:4891166 NCBI chrNW_004936694:2,702,224...2,724,574 JBrowse link
estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b1 hydroxysteroid 17-beta dehydrogenase 1 involved_in ISO
IEA
estradiol RGD
TreeGrafter
UniProt
Ensembl
InterPro
PMID:8612487 GO_REF:0000002 GO_REF:0000041 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:728619 NCBI chrNW_004936490:17,312,390...17,314,423
Ensembl chrNW_004936490:17,312,390...17,314,409
JBrowse link
G Hsd17b2 hydroxysteroid 17-beta dehydrogenase 2 involved_in ISO
IEA
estrone RGD
Ensembl
PMID:8612487 GO_REF:0000107 RGD:728619 NCBI chrNW_004936475:29,426,922...29,494,215
Ensembl chrNW_004936475:29,426,883...29,494,225
JBrowse link
G Hsd17b7 hydroxysteroid 17-beta dehydrogenase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936831:951,603...976,159
Ensembl chrNW_004936831:951,562...977,208
JBrowse link
G Hsd17b8 hydroxysteroid 17-beta dehydrogenase 8 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936476:25,648,604...25,650,757
Ensembl chrNW_004936476:25,648,604...25,650,757
JBrowse link
G LOC101954950 aromatase ISO estrone RGD PMID:19665544 RGD:4891164 NCBI chrNW_004936471:13,107,603...13,136,910
Ensembl chrNW_004936471:13,107,603...13,136,910
JBrowse link
G Rdh8 retinol dehydrogenase 8 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936659:439,541...445,645 JBrowse link
G Star steroidogenic acute regulatory protein ISO estradiol; positive regulation RGD PMID:16579833 RGD:1600078 NCBI chrNW_004936710:1,523,289...1,530,181
Ensembl chrNW_004936710:1,523,355...1,529,672
JBrowse link
glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:10861000) Ensembl
MGI
PMID:10861000 GO_REF:0000107 NCBI chrNW_004936496:7,759,656...7,761,555
Ensembl chrNW_004936496:7,760,532...7,761,122
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 ISO RGD PMID:12460758 RGD:1625060 NCBI chrNW_004936557:3,358,809...3,403,461
Ensembl chrNW_004936557:3,357,016...3,403,714
JBrowse link
G LOC101957714 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936514:1,467,460...1,480,185
Ensembl chrNW_004936514:1,467,261...1,480,185
JBrowse link
G LOC101963150 sterol 26-hydroxylase, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936569:1,213,700...1,250,181
Ensembl chrNW_004936569:1,213,573...1,250,589
JBrowse link
G LOC101968373 cytochrome P450 11B3, mitochondrial-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936470:9,034,177...9,039,486 JBrowse link
G LOC101970767 steroid 17-alpha-hydroxylase/17,20 lyase involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:7588219) Ensembl
MGI
PMID:7588219 GO_REF:0000107 NCBI chrNW_004936600:3,097,620...3,102,713
Ensembl chrNW_004936600:3,097,638...3,102,713
JBrowse link
G LOC101975820 cholesterol side-chain cleavage enzyme, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936471:33,367,810...33,380,764
Ensembl chrNW_004936471:33,367,810...33,380,764
JBrowse link
G LOC101978323 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936646:1,899,686...1,904,104
Ensembl chrNW_004936646:1,900,259...1,904,104
JBrowse link
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:12,428,765...12,439,570
Ensembl chrNW_004936485:12,428,710...12,439,454
JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:5,350,870...5,464,561
Ensembl chrNW_004936476:5,350,870...5,464,354
JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936528:6,428,824...6,477,007
Ensembl chrNW_004936528:6,429,973...6,477,218
JBrowse link
G Rest RE1 silencing transcription factor involved_in ISO (PMID:19342457) UniProt PMID:19342457 RGD:4891166 NCBI chrNW_004936482:19,018,454...19,040,438 JBrowse link
negative regulation of androgen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt4 Wnt family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:7,623,462...7,635,416
Ensembl chrNW_004936474:7,623,463...7,635,664
JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936485:12,428,765...12,439,570
Ensembl chrNW_004936485:12,428,710...12,439,454
JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:5,350,870...5,464,561
Ensembl chrNW_004936476:5,350,870...5,464,354
JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936528:6,428,824...6,477,007
Ensembl chrNW_004936528:6,429,973...6,477,218
JBrowse link
G Rest RE1 silencing transcription factor involved_in ISO (PMID:19342457) UniProt PMID:19342457 RGD:4891166 NCBI chrNW_004936482:19,018,454...19,040,438 JBrowse link
negative regulation of estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chrNW_004936552:7,204,298...7,212,632 JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17234593) Ensembl
MGI
PMID:17234593 GO_REF:0000107 NCBI chrNW_004936627:1,555,151...1,584,370
Ensembl chrNW_004936627:1,554,873...1,584,638
JBrowse link
negative regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chrNW_004936552:7,204,298...7,212,632 JBrowse link
positive regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936534:4,707,658...4,871,865
Ensembl chrNW_004936534:4,709,064...4,871,023
JBrowse link
G Dab2 DAB adaptor protein 2 ISO RGD PMID:17303656 RGD:7243836 NCBI chrNW_004936518:2,915,819...2,936,474
Ensembl chrNW_004936518:2,915,764...2,937,875
JBrowse link
G Wnt4 Wnt family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:7,623,462...7,635,416
Ensembl chrNW_004936474:7,623,463...7,635,664
JBrowse link
positive regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt4 Wnt family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:7,623,462...7,635,416
Ensembl chrNW_004936474:7,623,463...7,635,664
JBrowse link
positive regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppargc1a PPARG coactivator 1 alpha ISO RGD PMID:20133449 RGD:10059648 NCBI chrNW_004936477:4,881,230...5,488,208
Ensembl chrNW_004936477:5,199,881...5,488,226
JBrowse link
progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scp2 sterol carrier protein 2 involved_in ISO (PMID:1703300) UniProt PMID:1703300 NCBI chrNW_004936522:8,004,503...8,110,995
Ensembl chrNW_004936522:8,005,442...8,110,889
JBrowse link
G Stard3 StAR related lipid transfer domain containing 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14963026) Ensembl
MGI
PMID:14963026 GO_REF:0000107 NCBI chrNW_004936490:14,832,067...14,856,330
Ensembl chrNW_004936490:14,832,067...14,857,722
JBrowse link
regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcn2 chloride voltage-gated channel 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936578:5,525,461...5,539,351
Ensembl chrNW_004936578:5,525,601...5,539,472
JBrowse link
regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgkq diacylglycerol kinase theta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936477:22,225,624...22,238,825
Ensembl chrNW_004936477:22,225,618...22,238,803
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936623:3,359,624...3,376,598
Ensembl chrNW_004936623:3,351,716...3,375,146
JBrowse link
regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3 group C member 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:7628695) Ensembl
MGI
PMID:7628695 GO_REF:0000107 NCBI chrNW_004936504:10,960,069...11,056,834
Ensembl chrNW_004936504:10,959,192...11,056,856
JBrowse link
regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgkq diacylglycerol kinase theta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936477:22,225,624...22,238,825
Ensembl chrNW_004936477:22,225,618...22,238,803
JBrowse link
G Egr1 early growth response 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936531:7,625,956...7,629,041
Ensembl chrNW_004936531:7,625,892...7,629,749
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15969
    metabolic process 9630
      primary metabolic process 8425
        lipid metabolic process 1281
          steroid metabolic process 297
            steroid biosynthetic process 156
              steroid hormone biosynthetic process 37
                C21-steroid hormone biosynthetic process + 20
                androgen biosynthetic process + 6
                estrogen biosynthetic process + 8
                glucocorticoid biosynthetic process + 18
                mineralocorticoid biosynthetic process + 10
                vitamin D3 biosynthetic process 0
paths to the root