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ONTOLOGY REPORT - ANNOTATIONS


Term:steroid hormone biosynthetic process
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Accession:GO:0120178 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.



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aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1H calcium voltage-gated channel subunit alpha1 H involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:40,637,420...40,694,616
Ensembl chr 3:40,637,427...40,695,177
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 acts_upstream_of_or_within
involved_in
ISO
IEA
IBA
(MGI:50073|PMID:1686470), (MGI:80407|PMID:8645611) MGI
TreeGrafter
GO_Central
PMID:1686470 PMID:8645611 GO_REF:0000033 GO_REF:0000118 MGI:50073 MGI:80407 NCBI chr 4:1,365,725...1,373,138 JBrowse link
androgen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSD17B2 hydroxysteroid 17-beta dehydrogenase 2 ISO androstenedione RGD PMID:8612487 RGD:728619 NCBI chr 6:6,296,429...6,360,434
Ensembl chr 6:6,292,707...6,360,633
JBrowse link
G MED1 mediator complex subunit 1 involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr12:22,830,405...22,872,420
Ensembl chr12:22,841,205...22,872,409
JBrowse link
G SCARB1 scavenger receptor class B member 1 ISO RGD PMID:12746305 RGD:1304382 NCBI chr14:28,301,421...28,393,568
Ensembl chr14:28,301,294...28,393,568
JBrowse link
G SRD5A1 steroid 5 alpha-reductase 1 involved_in
acts_upstream_of_or_within
ISO
IEA
dihydrotestosterone
(MGI:3045995|PMID:15249131)
RGD
UniProt
MGI
PMID:12606426 PMID:15249131 GO_REF:0000117 MGI:3045995 RGD:4891962 NCBI chr16:75,309,830...75,335,438
Ensembl chr16:75,310,211...75,335,391
JBrowse link
G SRD5A2 steroid 5 alpha-reductase 2 involved_in
acts_upstream_of_or_within
ISO
IEA
dihydrotestosterone
(MGI:3045995|PMID:15249131)
RGD
UniProt
MGI
PMID:12606426 PMID:15249131 GO_REF:0000117 MGI:3045995 RGD:4891962 NCBI chr 3:107,840,200...107,918,351
Ensembl chr 3:107,840,200...107,918,350
JBrowse link
C21-steroid hormone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 involved_in
acts_upstream_of_or_within
ISO
IEA
IBA
ISS
pregnenolone
(MGI:68080|PMID:7527351)
RGD
TreeGrafter
GO_Central
UniProt
Ensembl
MGI
PMID:7527351 PMID:19665544 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 MGI:68080 RGD:4891164 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 involved_in ISO (PMID:2256920) BHF-UCL PMID:2256920 NCBI chr 4:1,365,725...1,373,138 JBrowse link
G CYP24A1 cytochrome P450 family 24 subfamily A member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:55,110,546...55,130,328
Ensembl chr17:55,110,590...55,130,363
JBrowse link
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr15:120,809,886...120,852,196
Ensembl chr15:120,809,959...120,852,192
JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:23,053,129...23,058,865
Ensembl chr 5:23,053,892...23,058,470
JBrowse link
cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1H calcium voltage-gated channel subunit alpha1 H involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:40,637,420...40,694,616
Ensembl chr 3:40,637,427...40,695,177
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 involved_in
NOT|involved_in
ISO (PMID:19342457)
(PMID:9703385)
UniProt
BHF-UCL
PMID:9703385 PMID:19342457 NCBI chr 4:1,365,725...1,373,138 JBrowse link
estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP19A2 cytochrome P450 19A2 ISO estrone RGD PMID:19665544 RGD:4891164 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 involved_in ISO
IBA
IEA
estradiol RGD
GO_Central
TreeGrafter
UniProt
Ensembl
InterPro
PMID:8612487 GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:728619 NCBI chr12:20,269,468...20,271,349
Ensembl chr12:20,269,056...20,271,548
JBrowse link
G HSD17B2 hydroxysteroid 17-beta dehydrogenase 2 involved_in ISO
IEA
estrone RGD
Ensembl
PMID:8612487 GO_REF:0000107 RGD:728619 NCBI chr 6:6,296,429...6,360,434
Ensembl chr 6:6,292,707...6,360,633
JBrowse link
G HSD17B7 hydroxysteroid 17-beta dehydrogenase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:87,720,747...87,743,037
Ensembl chr 4:87,720,118...87,742,992
JBrowse link
G HSD17B8 hydroxysteroid 17-beta dehydrogenase 8 involved_in IEA
IBA
ISS
Ensembl
TreeGrafter
GO_Central
UniProt
GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:25,247,577...25,249,786
Ensembl chr 7:25,247,608...25,249,785
JBrowse link
G RDH8 retinol dehydrogenase 8 involved_in IEA InterPro GO_REF:0000002 NCBI chr 2:68,871,707...68,878,222
Ensembl chr 2:68,871,707...68,877,675
JBrowse link
G STAR steroidogenic acute regulatory protein ISO estradiol; positive regulation RGD PMID:16579833 RGD:1600078 NCBI chr15:48,377,597...48,385,398
Ensembl chr15:48,377,521...48,385,462
JBrowse link
glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRH corticotropin releasing hormone acts_upstream_of_or_within ISO (MGI:1860037|PMID:10861000) MGI PMID:10861000 MGI:1860037 NCBI chr 4:68,481,696...68,486,122
Ensembl chr 4:68,484,053...68,486,121
JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 involved_in IBA
IEA
GO_Central
TreeGrafter
GO_REF:0000033 GO_REF:0000118 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 involved_in IEA
IBA
TreeGrafter
GO_Central
GO_REF:0000033 GO_REF:0000118 NCBI chr 4:1,365,725...1,373,138 JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:77279|PMID:7588219) MGI
UniProt
PMID:7588219 GO_REF:0000041 MGI:77279 NCBI chr14:113,805,616...113,820,445
Ensembl chr14:113,805,611...113,812,041
JBrowse link
G CYP21A1 cytochrome P450 family 21 subfamily A member 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:24,086,138...24,089,364
Ensembl chr 7:24,086,218...24,089,370
JBrowse link
G CYP24A1 cytochrome P450 family 24 subfamily A member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:55,110,546...55,130,328
Ensembl chr17:55,110,590...55,130,363
JBrowse link
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr15:120,809,886...120,852,196
Ensembl chr15:120,809,959...120,852,192
JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:23,053,129...23,058,865
Ensembl chr 5:23,053,892...23,058,470
JBrowse link
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 ISO RGD PMID:12460758 RGD:1625060 NCBI chr 9:133,231,451...133,278,396
Ensembl chr 9:133,231,451...133,278,396
JBrowse link
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:15,750,487...15,762,982
Ensembl chr17:15,749,835...15,761,195
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:25,344,924...25,468,430
Ensembl chr 7:25,344,822...25,470,470
JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:47,385,244...47,444,664
Ensembl chr 2:47,385,192...47,444,660
JBrowse link
G LOC100621006 RE1-silencing transcription factor-like involved_in ISS UniProt GO_REF:0000024 NCBI chr 8:56,048,280...56,215,011
Ensembl chr 8:56,035,150...56,215,013
JBrowse link
G REST RE1 silencing transcription factor involved_in ISS UniProt GO_REF:0000024 NCBI chr 8:56,035,182...56,061,140
Ensembl chr 8:56,035,150...56,215,013
JBrowse link
negative regulation of androgen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT4 Wnt family member 4 involved_in ISO (PMID:16959810) UniProt PMID:16959810 NCBI chr 6:80,110,238...80,138,165 JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:15,750,487...15,762,982
Ensembl chr17:15,749,835...15,761,195
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:25,344,924...25,468,430
Ensembl chr 7:25,344,822...25,470,470
JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:47,385,244...47,444,664
Ensembl chr 2:47,385,192...47,444,660
JBrowse link
G LOC100621006 RE1-silencing transcription factor-like involved_in ISS UniProt GO_REF:0000024 NCBI chr 8:56,048,280...56,215,011
Ensembl chr 8:56,035,150...56,215,013
JBrowse link
G REST RE1 silencing transcription factor involved_in ISS UniProt GO_REF:0000024 NCBI chr 8:56,035,182...56,061,140
Ensembl chr 8:56,035,150...56,215,013
JBrowse link
negative regulation of estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRL prolactin involved_in IMP (PMID:24530842) AgBase PMID:24530842 NCBI chr 7:17,451,367...17,463,771
Ensembl chr 7:17,451,367...17,463,710
JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3696486|PMID:17234593) MGI
Ensembl
PMID:17234593 GO_REF:0000107 MGI:3696486 NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,508...104,384,547
JBrowse link
negative regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRL prolactin involved_in IMP (PMID:24530842) AgBase PMID:24530842 NCBI chr 7:17,451,367...17,463,771
Ensembl chr 7:17,451,367...17,463,710
JBrowse link
positive regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP6 bone morphogenetic protein 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:5,058,817...5,208,868
Ensembl chr 7:5,058,817...5,210,270
JBrowse link
G DAB2 DAB adaptor protein 2 ISO RGD PMID:17303656 RGD:7243836 NCBI chr16:24,590,638...24,776,937
Ensembl chr16:24,590,645...24,646,122
JBrowse link
G WNT4 Wnt family member 4 involved_in ISO (PMID:16981135) UniProt PMID:16981135 NCBI chr 6:80,110,238...80,138,165 JBrowse link
positive regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT4 Wnt family member 4 involved_in ISO (PMID:16981135) UniProt PMID:16981135 NCBI chr 6:80,110,238...80,138,165 JBrowse link
positive regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARGC1A PPARG coactivator 1 alpha ISO RGD PMID:20133449 RGD:10059648 NCBI chr 8:17,841,844...18,527,953
Ensembl chr 8:17,841,844...17,946,992
JBrowse link
progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 ISO RGD PMID:1955079 RGD:1625116 NCBI chr 4:101,565,229...101,574,110 JBrowse link
G SCP2 sterol carrier protein 2 involved_in ISO (PMID:1703300) UniProt PMID:1703300 NCBI chr 6:159,191,045...159,314,985 JBrowse link
G STARD3 StAR related lipid transfer domain containing 3 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3039987|PMID:14963026) MGI
Ensembl
PMID:14963026 GO_REF:0000107 MGI:3039987 NCBI chr12:22,654,920...22,680,803
Ensembl chr12:22,654,584...22,680,783
JBrowse link
regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCN2 chloride voltage-gated channel 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:122,234,731...122,249,889
Ensembl chr13:122,234,736...122,249,867
JBrowse link
regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DGKQ diacylglycerol kinase theta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:313,325...325,089
Ensembl chr 8:313,329...325,095
JBrowse link
G H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:69,666,348...69,700,303
Ensembl chr 6:69,666,601...69,700,298
JBrowse link
regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR3C1 nuclear receptor subfamily 3 group C member 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:74913|PMID:7628695) MGI
Ensembl
PMID:7628695 GO_REF:0000107 MGI:74913 NCBI chr 2:144,822,937...144,956,451
Ensembl chr 2:144,822,939...144,956,451
JBrowse link
regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DGKQ diacylglycerol kinase theta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:313,325...325,089
Ensembl chr 8:313,329...325,095
JBrowse link
G EGR1 early growth response 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:140,440,829...140,445,302
Ensembl chr 2:140,441,421...140,445,296
JBrowse link
G MIR125A microRNA mir-125a ISO RGD PMID:23045399 RGD:26884342 NCBI chr 6:58,331,566...58,331,645
Ensembl chr 6:58,331,566...58,331,645
JBrowse link
G MIR455 microRNA mir-455 ISO RGD PMID:23045399 RGD:26884342 NCBI chr 1:254,824,200...254,824,279
Ensembl chr 1:254,824,196...254,824,291
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17816
    metabolic process 10350
      primary metabolic process 9002
        lipid metabolic process 1355
          steroid metabolic process 317
            steroid biosynthetic process 166
              steroid hormone biosynthetic process 42
                C21-steroid hormone biosynthetic process + 24
                androgen biosynthetic process + 6
                estrogen biosynthetic process + 8
                glucocorticoid biosynthetic process + 20
                mineralocorticoid biosynthetic process + 11
                vitamin D3 biosynthetic process 0
paths to the root