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ONTOLOGY REPORT - ANNOTATIONS


Term:steroid hormone biosynthetic process
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Accession:GO:0120178 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.


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aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in ISO (PMID:19342457) UniProt PMID:19342457 RGD:4891166 NCBI chrNW_004624913:1,926,405...1,952,426
Ensembl chrNW_004624913:1,891,156...1,949,633
JBrowse link
G LOC101700701 cytochrome P450 11B1, mitochondrial involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:1686470), (PMID:8645611) TreeGrafter
MGI
PMID:1686470 PMID:8645611 GO_REF:0000118 NCBI chrNW_004624735:13,701,382...13,708,750 JBrowse link
G LOC101701311 cytochrome P450 11B1, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624735:13,726,649...13,734,536 JBrowse link
androgen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b2 hydroxysteroid 17-beta dehydrogenase 2 ISO androstenedione RGD PMID:8612487 RGD:728619 NCBI chrNW_004624746:5,372,176...5,445,726
Ensembl chrNW_004624746:5,368,142...5,446,429
JBrowse link
G Med1 mediator complex subunit 1 involved_in ISO (PMID:19497978) UniProt PMID:19497978 NCBI chrNW_004624795:3,572,025...3,605,675
Ensembl chrNW_004624795:3,572,266...3,607,126
JBrowse link
G Scarb1 scavenger receptor class B member 1 ISO RGD PMID:12746305 RGD:1304382 NCBI chrNW_004624747:23,970,782...24,010,683
Ensembl chrNW_004624747:23,973,648...24,010,820
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 involved_in
acts_upstream_of_or_within
ISO
IEA
dihydrotestosterone
(PMID:15249131)
RGD
UniProt
MGI
PMID:12606426 PMID:15249131 GO_REF:0000117 RGD:4891962 NCBI chrNW_004624751:4,309,518...4,335,332
Ensembl chrNW_004624751:4,309,447...4,336,083
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 acts_upstream_of_or_within
involved_in
ISO
IEA
dihydrotestosterone
(PMID:15249131)
RGD
MGI
UniProt
Ensembl
PMID:12606426 PMID:15249131 GO_REF:0000107 GO_REF:0000117 RGD:4891962 NCBI chrNW_004624738:13,254,998...13,321,360
Ensembl chrNW_004624738:13,253,729...13,321,448
JBrowse link
C21-steroid hormone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101700018 sterol 26-hydroxylase, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624823:6,199,807...6,258,273
Ensembl chrNW_004624823:6,200,047...6,258,001
JBrowse link
G LOC101700701 cytochrome P450 11B1, mitochondrial involved_in ISO (PMID:2256920) BHF-UCL PMID:2256920 NCBI chrNW_004624735:13,701,382...13,708,750 JBrowse link
G LOC101700851 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624802:10,176,865...10,181,725
Ensembl chrNW_004624802:10,176,919...10,181,657
JBrowse link
G LOC101704598 cholesterol side-chain cleavage enzyme, mitochondrial acts_upstream_of_or_within
involved_in
ISO
IEA
pregnenolone
(PMID:7527351)
RGD
MGI
Ensembl
TreeGrafter
PMID:7527351 PMID:19665544 GO_REF:0000107 GO_REF:0000118 RGD:4891164 NCBI chrNW_004624781:288,594...298,876
Ensembl chrNW_004624781:288,594...300,429
JBrowse link
G LOC101716773 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624790:2,183,079...2,200,219
Ensembl chrNW_004624790:2,182,598...2,200,425
JBrowse link
cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in ISO PMID:19342457
(PMID:19342457)
UniProt PMID:19342457 RGD:4891166 NCBI chrNW_004624913:1,926,405...1,952,426
Ensembl chrNW_004624913:1,891,156...1,949,633
JBrowse link
G LOC101700701 cytochrome P450 11B1, mitochondrial NOT|involved_in ISO (PMID:9703385)
(PMID:19342457)
BHF-UCL
UniProt
PMID:9703385 PMID:19342457 NCBI chrNW_004624735:13,701,382...13,708,750 JBrowse link
estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b1 hydroxysteroid 17-beta dehydrogenase 1 involved_in ISO
IEA
estradiol RGD
InterPro
TreeGrafter
PMID:8612487 GO_REF:0000002 GO_REF:0000118 RGD:728619 NCBI chrNW_004624795:1,551,311...1,553,432
Ensembl chrNW_004624795:1,551,311...1,553,493
JBrowse link
G Hsd17b2 hydroxysteroid 17-beta dehydrogenase 2 involved_in ISO (PMID:11940569)
estrone
UniProt
RGD
PMID:8612487 PMID:11940569 RGD:728619 NCBI chrNW_004624746:5,372,176...5,445,726
Ensembl chrNW_004624746:5,368,142...5,446,429
JBrowse link
G Hsd17b7 hydroxysteroid 17-beta dehydrogenase 7 involved_in ISO (MGI:1267145|PMID:9658408), (MGI:2662631|PMID:12732193)
(PMID:12732193)
UniProt PMID:9658408 PMID:12732193 MGI:1267145 MGI:2662631 RGD:30309934 NCBI chrNW_004624826:1,260,133...1,287,565
Ensembl chrNW_004624826:1,260,223...1,283,741
JBrowse link
G Hsd17b8 hydroxysteroid 17-beta dehydrogenase 8 involved_in ISO (PMID:17978863) UniProt PMID:17978863 NCBI chrNW_004624754:23,600,706...23,602,786
Ensembl chrNW_004624754:23,600,706...23,602,751
JBrowse link
G LOC101702005 aromatase ISO estrone RGD PMID:19665544 RGD:4891164 NCBI chrNW_004624731:9,053,644...9,100,212
Ensembl chrNW_004624731:9,053,803...9,100,212
JBrowse link
G Rdh8 retinol dehydrogenase 8 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624828:2,254,570...2,259,512
Ensembl chrNW_004624828:2,253,995...2,260,315
JBrowse link
G Star steroidogenic acute regulatory protein ISO estradiol; positive regulation RGD PMID:16579833 RGD:1600078 NCBI chrNW_004624780:5,494,430...5,501,063
Ensembl chrNW_004624780:5,493,786...5,502,030
JBrowse link
glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone acts_upstream_of_or_within ISO (PMID:10861000) MGI PMID:10861000 NCBI chrNW_004624744:25,194,458...25,196,658
Ensembl chrNW_004624744:25,194,495...25,196,488
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 ISO RGD PMID:12460758 RGD:1625060 NCBI chrNW_004624807:2,260,702...2,293,962
Ensembl chrNW_004624807:2,261,006...2,293,804
JBrowse link
G LOC101700018 sterol 26-hydroxylase, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624823:6,199,807...6,258,273
Ensembl chrNW_004624823:6,200,047...6,258,001
JBrowse link
G LOC101700701 cytochrome P450 11B1, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624735:13,701,382...13,708,750 JBrowse link
G LOC101700851 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624802:10,176,865...10,181,725
Ensembl chrNW_004624802:10,176,919...10,181,657
JBrowse link
G LOC101701311 cytochrome P450 11B1, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624735:13,726,649...13,734,536 JBrowse link
G LOC101704598 cholesterol side-chain cleavage enzyme, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624781:288,594...298,876
Ensembl chrNW_004624781:288,594...300,429
JBrowse link
G LOC101716773 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624790:2,183,079...2,200,219
Ensembl chrNW_004624790:2,182,598...2,200,425
JBrowse link
G LOC101726496 steroid 17-alpha-hydroxylase/17,20 lyase acts_upstream_of_or_within ISO (PMID:7588219) MGI PMID:7588219 NCBI chrNW_004624831:2,155,851...2,166,621
Ensembl chrNW_004624831:2,157,048...2,166,539
JBrowse link
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in ISO (PMID:19584291) BHF-UCL PMID:19584291 NCBI chrNW_004624741:7,706,205...7,717,677
Ensembl chrNW_004624741:7,706,236...7,719,484
JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) BHF-UCL PMID:19584291 NCBI chrNW_004624850:3,324,553...3,481,439
Ensembl chrNW_004624850:3,322,782...3,481,512
JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624766:4,042,307...4,085,613
Ensembl chrNW_004624766:4,041,816...4,085,209
JBrowse link
G Rest RE1 silencing transcription factor involved_in ISO PMID:19342457
(PMID:19342457)
UniProt PMID:19342457 RGD:4891166 NCBI chrNW_004624761:12,464,243...12,495,294 JBrowse link
negative regulation of androgen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt4 Wnt family member 4 involved_in ISO (PMID:16959810) UniProt PMID:16959810 NCBI chrNW_004624764:6,913,027...6,934,650
Ensembl chrNW_004624764:6,921,811...6,933,392
JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in ISO (PMID:19584291) BHF-UCL PMID:19584291 NCBI chrNW_004624741:7,706,205...7,717,677
Ensembl chrNW_004624741:7,706,236...7,719,484
JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) BHF-UCL PMID:19584291 NCBI chrNW_004624850:3,324,553...3,481,439
Ensembl chrNW_004624850:3,322,782...3,481,512
JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624766:4,042,307...4,085,613
Ensembl chrNW_004624766:4,041,816...4,085,209
JBrowse link
G Rest RE1 silencing transcription factor involved_in ISO (PMID:19342457) UniProt PMID:19342457 RGD:4891166 NCBI chrNW_004624761:12,464,243...12,495,294 JBrowse link
negative regulation of estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chrNW_004624756:4,585,542...4,593,285 JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 acts_upstream_of_or_within ISO (PMID:17234593) MGI PMID:17234593 NCBI chrNW_004624772:12,099,523...12,127,437
Ensembl chrNW_004624772:12,099,435...12,127,737
JBrowse link
negative regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chrNW_004624756:4,585,542...4,593,285 JBrowse link
positive regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 involved_in ISO (PMID:16527843) UniProt PMID:16527843 NCBI chrNW_004624756:17,742,822...17,894,931
Ensembl chrNW_004624756:17,743,834...17,894,753
JBrowse link
G Dab2 DAB adaptor protein 2 ISO RGD PMID:17303656 RGD:7243836 NCBI chrNW_004624759:15,459,436...15,520,225
Ensembl chrNW_004624759:15,459,288...15,520,924
JBrowse link
G Wnt4 Wnt family member 4 involved_in ISO (PMID:16981135) UniProt PMID:16981135 NCBI chrNW_004624764:6,913,027...6,934,650
Ensembl chrNW_004624764:6,921,811...6,933,392
JBrowse link
positive regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt4 Wnt family member 4 involved_in ISO (PMID:16981135) UniProt PMID:16981135 NCBI chrNW_004624764:6,913,027...6,934,650
Ensembl chrNW_004624764:6,921,811...6,933,392
JBrowse link
positive regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppargc1a PPARG coactivator 1 alpha ISO RGD PMID:20133449 RGD:10059648 NCBI chrNW_004624755:7,826,219...8,460,746
Ensembl chrNW_004624755:8,375,596...8,465,297
JBrowse link
progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scp2 sterol carrier protein 2 involved_in ISO (PMID:1703300) UniProt PMID:1703300 NCBI chrNW_004624859:106,405...252,870
Ensembl chrNW_004624859:107,258...252,756
JBrowse link
G Stard3 StAR related lipid transfer domain containing 3 acts_upstream_of_or_within ISO (PMID:14963026) MGI PMID:14963026 NCBI chrNW_004624795:3,414,431...3,431,994
Ensembl chrNW_004624795:3,413,935...3,422,657
JBrowse link
regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcn2 chloride voltage-gated channel 2 involved_in ISO (PMID:29403011) UniProt PMID:29403011 NCBI chrNW_004624730:72,228,912...72,242,636
Ensembl chrNW_004624730:72,228,189...72,244,332
JBrowse link
regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgkq diacylglycerol kinase theta involved_in ISO (PMID:24369117) ParkinsonsUK-UCL PMID:24369117 NCBI chrNW_004624755:26,179,099...26,197,764
Ensembl chrNW_004624755:26,179,162...26,189,901
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase involved_in ISO (MGI:3623644|PMID:16356929)
(PMID:18628520), (PMID:23132696)
UniProt PMID:16356929 PMID:18628520 PMID:23132696 MGI:3623644 NCBI chrNW_004624818:3,025,323...3,052,486
Ensembl chrNW_004624818:3,025,252...3,051,260
JBrowse link
regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3 group C member 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:7628695) Ensembl
MGI
PMID:7628695 GO_REF:0000107 NCBI chrNW_004624774:2,496,276...2,603,894
Ensembl chrNW_004624774:2,495,304...2,602,632
JBrowse link
regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgkq diacylglycerol kinase theta involved_in ISO (PMID:24369117) ParkinsonsUK-UCL PMID:24369117 NCBI chrNW_004624755:26,179,099...26,197,764
Ensembl chrNW_004624755:26,179,162...26,189,901
JBrowse link
G Egr1 early growth response 1 involved_in ISO (MGI:82584|PMID:8703054) UniProt PMID:8703054 MGI:82584 NCBI chrNW_004624743:31,247,855...31,251,675
Ensembl chrNW_004624743:31,247,516...31,252,205
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15028
    metabolic process 9010
      primary metabolic process 7855
        lipid metabolic process 1197
          steroid metabolic process 271
            steroid biosynthetic process 152
              steroid hormone biosynthetic process 38
                C21-steroid hormone biosynthetic process + 21
                androgen biosynthetic process + 6
                estrogen biosynthetic process + 8
                glucocorticoid biosynthetic process + 19
                mineralocorticoid biosynthetic process + 11
                vitamin D3 biosynthetic process 0
paths to the root