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ONTOLOGY REPORT - ANNOTATIONS


Term:steroid hormone biosynthetic process
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Accession:GO:0120178 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.



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aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium channel, voltage-dependent, T type, alpha 1H subunit involved_in ISO MGI GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 NCBI chr17:25,593,259...25,655,308
Ensembl chr17:25,593,259...25,652,759
JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 involved_in ISO
IBA
MGI
GO_Central
GO_REF:0000033 GO_REF:0000096 MGI:4417868 NCBI chr15:74,706,741...74,713,492
Ensembl chr15:74,705,974...74,713,492
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 acts_upstream_of_or_within
involved_in
IDA
IBA
(PMID:1686470), (PMID:8645611) MGI
GO_Central
PMID:1686470 PMID:8645611 GO_REF:0000033 NCBI chr15:74,722,467...74,728,080
Ensembl chr15:74,722,859...74,728,167
JBrowse link
androgen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 involved_in ISO androstenedione RGD
MGI
PMID:8612487 GO_REF:0000096 MGI:4417868 RGD:728619 NCBI chr 8:118,427,752...118,485,767
Ensembl chr 8:118,428,643...118,485,766
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 3:98,618,423...98,631,859
Ensembl chr 3:98,616,571...98,631,859
JBrowse link
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 3:98,648,792...98,672,465
Ensembl chr 3:98,648,839...98,670,443
JBrowse link
G Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 3:98,712,820...98,721,759
Ensembl chr 3:98,712,820...98,721,759
JBrowse link
G Med1 mediator complex subunit 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:98,042,980...98,084,121
Ensembl chr11:98,042,980...98,084,119
JBrowse link
G Scarb1 scavenger receptor class B, member 1 involved_in ISO RGD
MGI
PMID:12746305 GO_REF:0000096 MGI:4417868 RGD:1304382 NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 acts_upstream_of_or_within
involved_in
ISO
IMP
dihydrotestosterone
(PMID:15249131)
RGD
MGI
PMID:12606426 PMID:15249131 GO_REF:0000096 MGI:4417868 RGD:4891962 NCBI chr13:69,721,568...69,759,611
Ensembl chr13:69,721,568...69,759,561
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 acts_upstream_of_or_within
involved_in
ISO
IMP
dihydrotestosterone
(PMID:15249131)
RGD
MGI
PMID:12606426 PMID:15249131 GO_REF:0000096 MGI:4417868 RGD:4891962 NCBI chr17:74,321,886...74,354,855
Ensembl chr17:74,323,950...74,354,911
JBrowse link
C21-steroid hormone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 involved_in
acts_upstream_of_or_within
ISO
IBA
IDA
pregnenolone
(PMID:7527351)
RGD
GO_Central
MGI
PMID:7527351 PMID:19665544 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:4891164 NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 involved_in ISO (PMID:2256920) BHF-UCL PMID:2256920 NCBI chr15:74,722,467...74,728,080
Ensembl chr15:74,722,859...74,728,167
JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr17:35,020,322...35,023,400
Ensembl chr17:35,020,322...35,023,535
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 3:98,618,423...98,631,859
Ensembl chr 3:98,616,571...98,631,859
JBrowse link
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 3:98,648,792...98,672,465
Ensembl chr 3:98,648,839...98,670,443
JBrowse link
G Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 3:98,712,820...98,721,759
Ensembl chr 3:98,712,820...98,721,759
JBrowse link
cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium channel, voltage-dependent, T type, alpha 1H subunit involved_in ISO MGI GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 NCBI chr17:25,593,259...25,655,308
Ensembl chr17:25,593,259...25,652,759
JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr15:74,706,741...74,713,492
Ensembl chr15:74,705,974...74,713,492
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 NOT|involved_in ISO (PMID:9703385)
(PMID:19342457)
BHF-UCL
UniProt
PMID:9703385 PMID:19342457 NCBI chr15:74,722,467...74,728,080
Ensembl chr15:74,722,859...74,728,167
JBrowse link
estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1b bone morphogenetic protein receptor, type 1B involved_in NAS (MGI:2136692|PMID:11416163) UniProt PMID:11416163 MGI:2136692 NCBI chr 3:141,540,230...141,875,335
Ensembl chr 3:141,542,897...141,875,186
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 involved_in ISO estrone RGD
MGI
PMID:19665544 GO_REF:0000096 MGI:4417868 RGD:4891164 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 involved_in IDA
IBA
ISO
(MGI:1267145|PMID:9658408)
estradiol
UniProt
GO_Central
MGI
RGD
PMID:8612487 PMID:9658408 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:1267145 MGI:4417868 MGI:4834177 RGD:728619 NCBI chr11:100,968,792...100,972,014
Ensembl chr11:100,969,237...100,971,353
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 involved_in ISO estrone RGD
MGI
PMID:8612487 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:728619 NCBI chr 8:118,427,752...118,485,767
Ensembl chr 8:118,428,643...118,485,766
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 involved_in IDA
ISO
(MGI:1267145|PMID:9658408), (MGI:2662631|PMID:12732193) UniProt
MGI
PMID:9658408 PMID:12732193 GO_REF:0000096 GO_REF:0000119 MGI:1267145 MGI:2662631 MGI:4417868 MGI:4834177 NCBI chr 1:169,777,109...169,796,757
Ensembl chr 1:169,777,104...169,796,810
JBrowse link
G Hsd17b8 hydroxysteroid 17-beta dehydrogenase 8 involved_in ISO
IBA
MGI
GO_Central
GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr17:34,245,007...34,247,029
Ensembl chr17:34,245,007...34,247,034
JBrowse link
G Star steroidogenic acute regulatory protein involved_in ISO estradiol; positive regulation RGD
MGI
PMID:16579833 GO_REF:0000096 MGI:4417868 RGD:1600078 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010
JBrowse link
glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone acts_upstream_of_or_within IMP (PMID:10861000) MGI PMID:10861000 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306
JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 involved_in
acts_upstream_of_or_within
ISO
IMP
IBA
IDA
(PMID:10224232)
(PMID:1686470), (PMID:8645611)
MGI
GO_Central
PMID:1686470 PMID:8645611 PMID:10224232 GO_REF:0000033 GO_REF:0000096 MGI:4417868 NCBI chr15:74,706,741...74,713,492
Ensembl chr15:74,705,974...74,713,492
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:74,722,467...74,728,080
Ensembl chr15:74,722,859...74,728,167
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 acts_upstream_of_or_within IDA (PMID:7588219) MGI PMID:7588219 NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611
JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:35,020,322...35,023,400
Ensembl chr17:35,020,322...35,023,535
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 involved_in ISO RGD
MGI
PMID:12460758 GO_REF:0000096 MGI:4417868 RGD:1625060 NCBI chr 1:192,903,917...192,946,345
Ensembl chr 1:192,903,942...192,946,383
JBrowse link
mineralocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr17:35,020,322...35,023,400
Ensembl chr17:35,020,322...35,023,535
JBrowse link
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805
JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 9:75,682,647...75,807,598
Ensembl chr 9:75,682,646...75,807,592
JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:111,715,226...111,758,689
Ensembl chr 7:111,715,224...111,758,264
JBrowse link
G Rest RE1-silencing transcription factor involved_in ISO MGI GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 NCBI chr 5:77,413,273...77,434,279
Ensembl chr 5:77,413,338...77,434,279
JBrowse link
negative regulation of androgen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt4 wingless-type MMTV integration site family, member 4 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:137,004,946...137,026,812
Ensembl chr 4:137,004,800...137,027,037
JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805
JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 9:75,682,647...75,807,598
Ensembl chr 9:75,682,646...75,807,592
JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:111,715,226...111,758,689
Ensembl chr 7:111,715,224...111,758,264
JBrowse link
G Rest RE1-silencing transcription factor involved_in ISO MGI GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 NCBI chr 5:77,413,273...77,434,279
Ensembl chr 5:77,413,338...77,434,279
JBrowse link
negative regulation of estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide acts_upstream_of_or_within IMP (PMID:17234593) MGI PMID:17234593 NCBI chr 3:101,483,535...101,512,023
Ensembl chr 3:101,483,535...101,512,000
JBrowse link
negative regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chr13:27,241,553...27,249,187
Ensembl chr13:27,241,553...27,249,188
JBrowse link
positive regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278
JBrowse link
G Dab2 disabled 2, mitogen-responsive phosphoprotein involved_in ISO RGD
MGI
PMID:17303656 GO_REF:0000096 MGI:4417868 RGD:7243836 NCBI chr15:6,329,269...6,470,196
Ensembl chr15:6,329,269...6,470,193
JBrowse link
G Wnt4 wingless-type MMTV integration site family, member 4 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:137,004,946...137,026,812
Ensembl chr 4:137,004,800...137,027,037
JBrowse link
positive regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt4 wingless-type MMTV integration site family, member 4 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:137,004,946...137,026,812
Ensembl chr 4:137,004,800...137,027,037
JBrowse link
positive regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha involved_in ISO RGD
MGI
PMID:20133449 GO_REF:0000096 MGI:4417868 RGD:10059648 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 ISO RGD PMID:1955079 RGD:1625116 NCBI chr 3:98,749,672...98,767,110
Ensembl chr 3:98,759,510...98,767,110
JBrowse link
G Scp2 sterol carrier protein 2, liver involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:107,901,027...108,002,168
Ensembl chr 4:107,901,036...108,002,195
JBrowse link
G Stard3 StAR related lipid transfer domain containing 3 acts_upstream_of_or_within IMP (PMID:14963026) MGI PMID:14963026 NCBI chr11:98,249,245...98,271,938
Ensembl chr11:98,249,194...98,271,938
JBrowse link
regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcn2 chloride channel, voltage-sensitive 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr16:20,521,185...20,536,496
Ensembl chr16:20,521,714...20,536,496
JBrowse link
regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgkq diacylglycerol kinase, theta involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:108,794,910...108,808,696
Ensembl chr 5:108,794,559...108,817,538
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) involved_in IMP
ISO
(MGI:3623644|PMID:16356929) UniProt
MGI
PMID:16356929 GO_REF:0000119 MGI:3623644 MGI:4834177 NCBI chr 4:150,063,931...150,093,480
Ensembl chr 4:150,063,932...150,093,480
JBrowse link
regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 acts_upstream_of_or_within IMP (PMID:7628695) MGI PMID:7628695 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474
JBrowse link
regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgkq diacylglycerol kinase, theta involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:108,794,910...108,808,696
Ensembl chr 5:108,794,559...108,817,538
JBrowse link
G Egr1 early growth response 1 involved_in IMP (MGI:82584|PMID:8703054) UniProt PMID:8703054 MGI:82584 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
JBrowse link
G Mir125a microRNA 125a ISO RGD PMID:23045399 RGD:26884342 NCBI chr17:18,051,074...18,051,141
Ensembl chr17:18,051,074...18,051,141
JBrowse link
G Mir455 microRNA 455 ISO RGD PMID:23045399 RGD:26884342 NCBI chr 4:63,175,088...63,175,169
Ensembl chr 4:63,175,088...63,175,169
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  biological_process 28573
    metabolic process 10995
      primary metabolic process 9507
        lipid metabolic process 1499
          steroid metabolic process 378
            steroid biosynthetic process 192
              steroid hormone biosynthetic process 42
                C21-steroid hormone biosynthetic process + 25
                androgen biosynthetic process + 9
                estrogen biosynthetic process + 8
                glucocorticoid biosynthetic process + 17
                mineralocorticoid biosynthetic process + 12
                vitamin D3 biosynthetic process 0
paths to the root