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ONTOLOGY REPORT - ANNOTATIONS


Term:steroid hormone biosynthetic process
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Accession:GO:0120178 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.



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aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1H calcium voltage-gated channel subunit alpha1 H involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:39,510,129...39,533,129
Ensembl chr 6:39,510,121...39,533,753
JBrowse link
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:1686470), (PMID:8645611) TreeGrafter
MGI
PMID:1686470 PMID:8645611 GO_REF:0000118 NCBI chr13:36,866,476...36,880,625 JBrowse link
G LOC119876933 cytochrome P450 11B1, mitochondrial-like involved_in IEA TreeGrafter GO_REF:0000118
androgen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSD17B2 hydroxysteroid 17-beta dehydrogenase 2 ISO androstenedione RGD PMID:8612487 RGD:728619 NCBI chr 5:69,927,888...70,009,306
Ensembl chr 5:69,927,984...70,009,179
JBrowse link
G HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 involved_in ISO (PMID:25322271) RGD
UniProt
PMID:1985917 PMID:25322271 RGD:632871 NCBI chr17:56,552,945...56,561,062
Ensembl chr17:56,552,945...56,561,062
JBrowse link
G MED1 mediator complex subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:22,989,257...23,019,350
Ensembl chr 9:22,989,301...23,019,349
JBrowse link
G SCARB1 scavenger receptor class B member 1 ISO RGD PMID:12746305 RGD:1304382 NCBI chr26:5,035,797...5,122,383
Ensembl chr26:5,049,407...5,121,468
JBrowse link
G SRD5A1 steroid 5 alpha-reductase 1 acts_upstream_of_or_within
involved_in
ISO
IEA
dihydrotestosterone
(PMID:15249131)
RGD
MGI
UniProt
PMID:12606426 PMID:15249131 GO_REF:0000117 RGD:4891962 NCBI chr34:7,118,814...7,144,828
Ensembl chr34:7,118,814...7,144,828
JBrowse link
G SRD5A2 steroid 5 alpha-reductase 2 acts_upstream_of_or_within
involved_in
ISO
IEA
dihydrotestosterone
(PMID:15249131)
RGD
MGI
UniProt
Ensembl
PMID:12606426 PMID:15249131 GO_REF:0000107 GO_REF:0000117 RGD:4891962 NCBI chr17:25,017,113...25,056,156
Ensembl chr17:25,017,113...25,056,544
JBrowse link
C21-steroid hormone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 acts_upstream_of_or_within
involved_in
ISO
IEA
pregnenolone
(PMID:7527351)
RGD
MGI
TreeGrafter
Ensembl
PMID:7527351 PMID:19665544 GO_REF:0000107 GO_REF:0000118 RGD:4891164 NCBI chr30:37,474,997...37,487,028
Ensembl chr30:37,473,901...37,487,507
JBrowse link
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 involved_in ISO (PMID:2256920) BHF-UCL PMID:2256920 NCBI chr13:36,866,476...36,880,625 JBrowse link
G CYP24A1 cytochrome P450 family 24 subfamily A member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr24:39,861,018...39,878,161
Ensembl chr24:39,862,355...39,878,216
JBrowse link
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr37:25,366,475...25,401,978
Ensembl chr37:25,366,472...25,401,509
JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr10:1,825,224...1,830,845
Ensembl chr10:1,826,046...1,829,911
JBrowse link
G CYP27C1 cytochrome P450 family 27 subfamily C member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:23,374,295...23,400,054 JBrowse link
G HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 ISO RGD PMID:1985917 RGD:632871 NCBI chr17:56,552,945...56,561,062
Ensembl chr17:56,552,945...56,561,062
JBrowse link
cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1H calcium voltage-gated channel subunit alpha1 H involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:39,510,129...39,533,129
Ensembl chr 6:39,510,121...39,533,753
JBrowse link
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 involved_in
NOT|involved_in
ISO (PMID:19342457)
(PMID:9703385)
UniProt
BHF-UCL
PMID:9703385 PMID:19342457 NCBI chr13:36,866,476...36,880,625 JBrowse link
estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 ISO estrone RGD PMID:19665544 RGD:4891164 NCBI chr30:16,954,020...17,056,728
Ensembl chr30:16,957,215...16,988,353
JBrowse link
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 involved_in ISO
IEA
estradiol RGD
InterPro
UniProt
Ensembl
TreeGrafter
PMID:8612487 GO_REF:0000002 GO_REF:0000041 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:728619 NCBI chr 9:20,402,124...20,407,143
Ensembl chr 9:20,405,019...20,406,792
JBrowse link
G HSD17B2 hydroxysteroid 17-beta dehydrogenase 2 involved_in ISO
IEA
estrone RGD
Ensembl
PMID:8612487 GO_REF:0000107 RGD:728619 NCBI chr 5:69,927,888...70,009,306
Ensembl chr 5:69,927,984...70,009,179
JBrowse link
G HSD17B7 hydroxysteroid 17-beta dehydrogenase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr38:19,975,935...19,999,077
Ensembl chr38:19,977,086...19,999,010
JBrowse link
G HSD17B8 hydroxysteroid 17-beta dehydrogenase 8 involved_in ISS
IEA
IBA
UniProt
TreeGrafter
GO_Central
GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000118 NCBI chr12:2,667,674...2,669,918
Ensembl chr12:2,663,515...2,669,917
JBrowse link
G RDH8 retinol dehydrogenase 8 involved_in IEA InterPro GO_REF:0000002 NCBI chr20:51,029,633...51,035,910
Ensembl chr20:51,029,609...51,035,951
JBrowse link
G SLC39A7 solute carrier family 39 member 7 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr12:2,663,807...2,667,527
Ensembl chr12:2,663,515...2,669,917
JBrowse link
G STAR steroidogenic acute regulatory protein ISO estradiol; positive regulation RGD PMID:16579833 RGD:1600078 NCBI chr16:27,326,355...27,331,025
Ensembl chr16:27,326,355...27,331,025
JBrowse link
glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRH corticotropin releasing hormone involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:10861000) Ensembl
MGI
PMID:10861000 GO_REF:0000107 NCBI chr29:15,831,944...15,840,560
Ensembl chr29:15,831,944...15,834,384
JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr30:37,474,997...37,487,028
Ensembl chr30:37,473,901...37,487,507
JBrowse link
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr13:36,866,476...36,880,625 JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:7588219) Ensembl
MGI
PMID:7588219 GO_REF:0000107 NCBI chr28:15,292,959...15,298,896
Ensembl chr28:15,293,106...15,298,852
JBrowse link
G CYP24A1 cytochrome P450 family 24 subfamily A member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr24:39,861,018...39,878,161
Ensembl chr24:39,862,355...39,878,216
JBrowse link
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr37:25,366,475...25,401,978
Ensembl chr37:25,366,472...25,401,509
JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr10:1,825,224...1,830,845
Ensembl chr10:1,826,046...1,829,911
JBrowse link
G CYP27C1 cytochrome P450 family 27 subfamily C member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:23,374,295...23,400,054 JBrowse link
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 ISO RGD PMID:12460758 RGD:1625060 NCBI chr 7:8,344,380...8,409,901
Ensembl chr 7:8,344,447...8,409,897
JBrowse link
G LOC119876933 cytochrome P450 11B1, mitochondrial-like involved_in IEA TreeGrafter GO_REF:0000118
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:15,199,667...15,211,509
Ensembl chr24:15,200,291...15,212,217
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:23,089,429...23,202,176
Ensembl chr12:23,089,459...23,202,348
JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:35,032,501...35,074,664
Ensembl chr21:35,033,552...35,074,664
JBrowse link
G REST RE1 silencing transcription factor involved_in ISO PMID:19342457
(PMID:19342457)
UniProt PMID:19342457 RGD:4891166 NCBI chr13:49,041,082...49,062,596
Ensembl chr13:49,041,047...49,059,388
JBrowse link
negative regulation of androgen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT4 Wnt family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:77,112,045...77,129,702
Ensembl chr 2:77,101,300...77,127,111
JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:15,199,667...15,211,509
Ensembl chr24:15,200,291...15,212,217
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:23,089,429...23,202,176
Ensembl chr12:23,089,459...23,202,348
JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:35,032,501...35,074,664
Ensembl chr21:35,033,552...35,074,664
JBrowse link
G REST RE1 silencing transcription factor involved_in ISO (PMID:19342457) UniProt PMID:19342457 RGD:4891166 NCBI chr13:49,041,082...49,062,596
Ensembl chr13:49,041,047...49,059,388
JBrowse link
negative regulation of estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRL prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chr35:20,673,830...20,683,824
Ensembl chr35:20,673,839...20,683,824
JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17234593) Ensembl
MGI
PMID:17234593 GO_REF:0000107 NCBI chr17:53,828,482...53,847,043
Ensembl chr17:53,813,976...53,847,167
JBrowse link
negative regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRL prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chr35:20,673,830...20,683,824
Ensembl chr35:20,673,839...20,683,824
JBrowse link
positive regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP6 bone morphogenetic protein 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr35:7,780,763...7,833,095
Ensembl chr35:7,804,231...7,831,845
JBrowse link
G DAB2 DAB adaptor protein 2 ISO RGD PMID:17303656 RGD:7243836 NCBI chr 4:69,625,874...69,648,349
Ensembl chr 4:69,625,527...69,648,321
JBrowse link
G WNT4 Wnt family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:77,112,045...77,129,702
Ensembl chr 2:77,101,300...77,127,111
JBrowse link
positive regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT4 Wnt family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:77,112,045...77,129,702
Ensembl chr 2:77,101,300...77,127,111
JBrowse link
positive regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARGC1A PPARG coactivator 1 alpha ISO RGD PMID:20133449 RGD:10059648 NCBI chr 3:85,645,942...86,284,570
Ensembl chr 3:86,016,140...86,281,269
JBrowse link
progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCP2 sterol carrier protein 2 involved_in ISO (PMID:1703300) UniProt PMID:1703300 NCBI chr 5:55,860,053...55,971,657
Ensembl chr 5:55,860,549...55,964,014
JBrowse link
G STARD3 StAR related lipid transfer domain containing 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14963026) Ensembl
MGI
PMID:14963026 GO_REF:0000107 NCBI chr 9:22,814,782...22,837,525
Ensembl chr 9:22,814,460...22,837,426
JBrowse link
regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCN2 chloride voltage-gated channel 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr34:17,224,136...17,238,755
Ensembl chr34:17,223,215...17,239,621
JBrowse link
regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DGKQ diacylglycerol kinase theta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:91,544,350...91,554,494
Ensembl chr 3:91,544,219...91,554,565
JBrowse link
G H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:62,548,136...62,577,346
Ensembl chr 5:62,548,221...62,608,964
JBrowse link
regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR3C1 nuclear receptor subfamily 3 group C member 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:7628695) Ensembl
MGI
PMID:7628695 GO_REF:0000107 NCBI chr 2:38,124,568...38,242,510
Ensembl chr 2:38,123,190...38,240,755
JBrowse link
regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DGKQ diacylglycerol kinase theta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:91,544,350...91,554,494
Ensembl chr 3:91,544,219...91,554,565
JBrowse link
G EGR1 early growth response 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575
JBrowse link
G MIR125A microRNA mir-125a ISO RGD PMID:23045399 RGD:26884342 NCBI chr 1:105,400,273...105,400,332
Ensembl chr 1:105,400,270...105,400,337
JBrowse link
G MIR455 microRNA mir-455 ISO RGD PMID:23045399 RGD:26884342 NCBI chr11:68,461,911...68,461,968
Ensembl chr11:68,461,896...68,461,983
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  biological_process 17878
    metabolic process 10933
      primary metabolic process 9494
        lipid metabolic process 1366
          steroid metabolic process 321
            steroid biosynthetic process 172
              steroid hormone biosynthetic process 43
                C21-steroid hormone biosynthetic process + 25
                androgen biosynthetic process + 7
                estrogen biosynthetic process + 9
                glucocorticoid biosynthetic process + 20
                mineralocorticoid biosynthetic process + 11
                vitamin D3 biosynthetic process 0
paths to the root