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ONTOLOGY REPORT - ANNOTATIONS


Term:steroid hormone biosynthetic process
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Accession:GO:0120178 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.



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aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1H calcium voltage-gated channel subunit alpha1 H involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:1,195,364...1,222,917 JBrowse link
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 involved_in ISO
IEA
RGD
TreeGrafter
Ensembl
PMID:11832364 GO_REF:0000107 GO_REF:0000118 RGD:727991 NCBI chr 8:139,584,976...139,592,466
Ensembl chr 8:142,629,127...142,634,654
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:1686470), (PMID:8645611) Ensembl
MGI
TreeGrafter
PMID:1686470 PMID:8645611 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:139,622,632...139,630,014
Ensembl chr 8:142,666,534...142,672,575
JBrowse link
androgen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSD17B2 hydroxysteroid 17-beta dehydrogenase 2 ISO androstenedione RGD PMID:8612487 RGD:728619 NCBI chr16:62,642,316...62,705,261
Ensembl chr16:82,062,042...82,125,139
JBrowse link
G HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 involved_in ISO
IEA
RGD
Ensembl
PMID:1985917 GO_REF:0000107 RGD:632871 NCBI chr 1:83,130,065...83,156,996
Ensembl chr 1:118,128,493...118,153,124
JBrowse link
G MED1 mediator complex subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:17,836,350...17,883,610
Ensembl chr17:18,050,474...18,095,118
JBrowse link
G SCARB1 scavenger receptor class B member 1 ISO RGD PMID:12746305 RGD:1304382 NCBI chr12:122,293,803...122,455,314
Ensembl chr12:126,659,532...126,694,767
JBrowse link
G SRD5A1 steroid 5 alpha-reductase 1 acts_upstream_of_or_within
involved_in
ISO
IEA
dihydrotestosterone
(PMID:15249131)
RGD
MGI
UniProt
PMID:12606426 PMID:15249131 GO_REF:0000117 RGD:4891962 NCBI chr 5:6,953,795...6,996,010
Ensembl chr 5:6,629,093...6,664,264
JBrowse link
G SRD5A2 steroid 5 alpha-reductase 2 acts_upstream_of_or_within
involved_in
ISO
IEA
dihydrotestosterone
(PMID:15249131)
RGD
MGI
UniProt
Ensembl
PMID:12606426 PMID:15249131 GO_REF:0000107 GO_REF:0000117 RGD:4891962 NCBI chr2A:31,542,646...31,597,394
Ensembl chr2A:31,610,487...31,665,718
JBrowse link
C21-steroid hormone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 acts_upstream_of_or_within
involved_in
ISO
IEA
pregnenolone
(PMID:7527351)
RGD
MGI
TreeGrafter
Ensembl
PMID:7527351 PMID:19665544 GO_REF:0000107 GO_REF:0000118 RGD:4891164 NCBI chr15:53,280,110...53,310,868
Ensembl chr15:72,901,286...72,931,164
JBrowse link
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 involved_in ISO
IEA
RGD
Ensembl
PMID:11832364 GO_REF:0000107 RGD:727991 NCBI chr 8:139,584,976...139,592,466
Ensembl chr 8:142,629,127...142,634,654
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:139,622,632...139,630,014
Ensembl chr 8:142,666,534...142,672,575
JBrowse link
G CYP24A1 cytochrome P450 family 24 subfamily A member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:50,500,103...50,520,487
Ensembl chr20:51,721,685...51,742,716
JBrowse link
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr2B:106,042,235...106,076,840
Ensembl chr2B:224,637,238...224,671,474
JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr12:31,158,814...31,164,462
Ensembl chr12:31,419,773...31,424,822
JBrowse link
G CYP27C1 cytochrome P450 family 27 subfamily C member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr2B:33,057,718...33,092,809
Ensembl chr2B:127,859,318...127,872,150
JBrowse link
G HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 ISO RGD PMID:1985917 RGD:632871 NCBI chr 1:83,130,065...83,156,996
Ensembl chr 1:118,128,493...118,153,124
JBrowse link
cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1H calcium voltage-gated channel subunit alpha1 H involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:1,195,364...1,222,917 JBrowse link
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:139,584,976...139,592,466
Ensembl chr 8:142,629,127...142,634,654
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 involved_in
NOT|involved_in
IEA
ISO
(PMID:9703385) Ensembl
BHF-UCL
PMID:9703385 GO_REF:0000107 NCBI chr 8:139,622,632...139,630,014
Ensembl chr 8:142,666,534...142,672,575
JBrowse link
estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 ISO estrone RGD PMID:19665544 RGD:4891164 NCBI chr15:30,152,924...30,282,854
Ensembl chr15:48,486,688...48,521,554
JBrowse link
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 involved_in ISO
IEA
estradiol RGD
TreeGrafter
InterPro
UniProt
Ensembl
PMID:8612487 GO_REF:0000002 GO_REF:0000041 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:728619 NCBI chr17:14,760,856...14,763,584
Ensembl chr17:14,986,814...14,988,820
JBrowse link
G HSD17B2 hydroxysteroid 17-beta dehydrogenase 2 involved_in ISO
IEA
estrone RGD
Ensembl
PMID:8612487 GO_REF:0000107 RGD:728619 NCBI chr16:62,642,316...62,705,261
Ensembl chr16:82,062,042...82,125,139
JBrowse link
G HSD17B7 hydroxysteroid 17-beta dehydrogenase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:138,204,544...138,226,689 JBrowse link
G HSD17B8 hydroxysteroid 17-beta dehydrogenase 8 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr 6:32,776,837...32,779,042
Ensembl chr 6:33,891,753...33,893,950
JBrowse link
G LOC100985156 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:38,424,713...38,447,193
Ensembl chr 1:142,001,162...142,022,865
JBrowse link
G RDH8 retinol dehydrogenase 8 involved_in IEA InterPro GO_REF:0000002 NCBI chr19:9,565,918...9,575,017
Ensembl chr19:10,226,185...10,235,114
JBrowse link
G STAR steroidogenic acute regulatory protein ISO estradiol; positive regulation RGD PMID:16579833 RGD:1600078 NCBI chr 8:37,446,334...37,454,102
Ensembl chr 8:34,623,201...34,629,544
JBrowse link
glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRH corticotropin releasing hormone involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:10861000) Ensembl
MGI
PMID:10861000 GO_REF:0000107 NCBI chr 8:62,714,721...62,716,979
Ensembl chr 8:64,383,419...64,384,009
JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr15:53,280,110...53,310,868
Ensembl chr15:72,901,286...72,931,164
JBrowse link
G CYP11B1 cytochrome P450 family 11 subfamily B member 1 involved_in ISO
IEA
corticosterone, 18-hydroxycorticosterone RGD
TreeGrafter
PMID:11832364 GO_REF:0000118 RGD:727991 NCBI chr 8:139,584,976...139,592,466
Ensembl chr 8:142,629,127...142,634,654
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:139,622,632...139,630,014
Ensembl chr 8:142,666,534...142,672,575
JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 acts_upstream_of_or_within ISO (PMID:7588219) MGI PMID:7588219 NCBI chr10:99,431,762...99,439,619
Ensembl chr10:102,896,376...102,901,514
JBrowse link
G CYP24A1 cytochrome P450 family 24 subfamily A member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:50,500,103...50,520,487
Ensembl chr20:51,721,685...51,742,716
JBrowse link
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr2B:106,042,235...106,076,840
Ensembl chr2B:224,637,238...224,671,474
JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr12:31,158,814...31,164,462
Ensembl chr12:31,419,773...31,424,822
JBrowse link
G CYP27C1 cytochrome P450 family 27 subfamily C member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr2B:33,057,718...33,092,809
Ensembl chr2B:127,859,318...127,872,150
JBrowse link
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 ISO RGD PMID:12460758 RGD:1625060 NCBI chr 1:185,262,599...185,311,417
Ensembl chr 1:190,086,449...190,116,765
JBrowse link
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:6,765,161...6,777,728
Ensembl chr20:6,546,173...6,558,610
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:55,302,721...55,425,248
Ensembl chr 6:56,936,850...57,059,519
JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:12,131,306...12,177,906
Ensembl chr11:11,824,955...11,871,139
JBrowse link
G REST RE1 silencing transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:66,984,466...67,012,301
Ensembl chr 4:73,526,085...73,582,242
JBrowse link
negative regulation of androgen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT4 Wnt family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:21,310,228...21,335,985
Ensembl chr 1:22,255,056...22,268,801
JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:6,765,161...6,777,728
Ensembl chr20:6,546,173...6,558,610
JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:55,302,721...55,425,248
Ensembl chr 6:56,936,850...57,059,519
JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:12,131,306...12,177,906
Ensembl chr11:11,824,955...11,871,139
JBrowse link
G REST RE1 silencing transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:66,984,466...67,012,301
Ensembl chr 4:73,526,085...73,582,242
JBrowse link
negative regulation of estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRL prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chr 6:22,109,974...22,125,433
Ensembl chr 6:22,450,132...22,459,829
JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:17234593) Ensembl
MGI
PMID:17234593 GO_REF:0000107 NCBI chr 1:86,162,401...86,193,883
Ensembl chr 1:121,212,488...121,243,099
JBrowse link
negative regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRL prolactin involved_in ISO (PMID:24530842) AgBase PMID:24530842 NCBI chr 6:22,109,974...22,125,433
Ensembl chr 6:22,450,132...22,459,829
JBrowse link
positive regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP6 bone morphogenetic protein 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:7,564,164...7,720,341
Ensembl chr 6:7,848,249...8,000,649
JBrowse link
G DAB2 DAB adaptor protein 2 ISO RGD PMID:17303656 RGD:7243836 NCBI chr 5:70,951,198...71,004,836
Ensembl chr 5:76,022,143...76,041,443
JBrowse link
G WNT4 Wnt family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:21,310,228...21,335,985
Ensembl chr 1:22,255,056...22,268,801
JBrowse link
positive regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT4 Wnt family member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:21,310,228...21,335,985
Ensembl chr 1:22,255,056...22,268,801
JBrowse link
positive regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARGC1A PPARG coactivator 1 alpha ISO RGD PMID:20133449 RGD:10059648 NCBI chr 4:18,196,431...18,876,889
Ensembl chr 4:23,483,377...23,581,212
JBrowse link
progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCP2 sterol carrier protein 2 involved_in ISO (PMID:1703300) UniProt PMID:1703300 NCBI chr 1:52,195,491...52,324,227
Ensembl chr 1:53,797,254...53,924,939
JBrowse link
G STARD3 StAR related lipid transfer domain containing 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:14963026) Ensembl
MGI
PMID:14963026 GO_REF:0000107 NCBI chr17:17,625,390...17,651,765
Ensembl chr17:17,842,217...17,868,535
JBrowse link
regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCN2 chloride voltage-gated channel 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:181,383,608...181,399,200
Ensembl chr 3:189,862,489...189,881,049
JBrowse link
regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DGKQ diacylglycerol kinase theta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:1,075,133...1,090,081
Ensembl chr 4:994,985...1,007,724
JBrowse link
G H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:7,996,315...8,031,987
Ensembl chr 1:9,232,666...9,256,631
JBrowse link
regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR3C1 nuclear receptor subfamily 3 group C member 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:7628695) Ensembl
MGI
PMID:7628695 GO_REF:0000107 NCBI chr 5:138,634,278...139,089,171
Ensembl chr 5:144,741,452...144,865,269
JBrowse link
regulation of progesterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DGKQ diacylglycerol kinase theta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:1,075,133...1,090,081
Ensembl chr 4:994,985...1,007,724
JBrowse link
G EGR1 early growth response 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:133,845,305...133,849,291
Ensembl chr 5:139,975,635...139,979,260
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16440
    metabolic process 10303
      primary metabolic process 8922
        lipid metabolic process 1301
          steroid metabolic process 302
            steroid biosynthetic process 158
              steroid hormone biosynthetic process 41
                C21-steroid hormone biosynthetic process + 23
                androgen biosynthetic process + 7
                estrogen biosynthetic process + 9
                glucocorticoid biosynthetic process + 20
                mineralocorticoid biosynthetic process + 11
                vitamin D3 biosynthetic process 0
paths to the root