ONTOLOGY REPORT - ANNOTATIONS


Term:ubiquitin activating enzyme complex
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Accession:GO:0120123 term browser browse the term
Definition:A protein complex responsible for the catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate.
Synonyms:exact_synonym: E1 complex
 related_synonym: E1 ubiquitin-activating enzyme
 xref: IntAct:EBI-16629455


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Path 1
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  cellular_component 18315
    cell part 16047
      intracellular part 12952
        ubiquitin activating enzyme complex 0
Path 2
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  cellular_component 18315
    cell 16117
      cell part 16047
        intracellular 12952
          intracellular part 12952
            ubiquitin activating enzyme complex 0
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