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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:cytoplasm to vacuole targeting by the NVT pathway
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Accession:GO:0120113 term browser browse the term
Definition:A pathway targeting soluble cytosolic proteins to the vacuole lumen. It uses a selective autophagy receptor protein Nbr1, which is an ortholog of mammalian NBR1, and is remotely related to S. cerevisiae Cvt pathway receptor protein Atg19. Similar to the Cvt pathway, the cargos transported by this pathway are hydrolases, which presumably contribute to the hydrolytic activities in the vacuole lumen. Different from the Cvt pathway, this pathway does not require the macroautophagy machinery, but instead relies on the ESCRT machinery for cargo sequestration. This pathway is observed in the fission yeast S. pombe.
Synonyms:exact_synonym: protein localization by the Nbr1-mediated vacuolar targeting pathway


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Path 1
Term Annotations click to browse term
  biological_process 19669
    cellular process 18300
      cellular localization 3868
        intracellular transport 1516
          vacuolar transport 196
            protein targeting to vacuole 59
              cytoplasm to vacuole targeting by the NVT pathway 0
Path 2
Term Annotations click to browse term
  biological_process 19669
    localization 5869
      macromolecule localization 3400
        cellular macromolecule localization 2883
          protein localization 2870
            protein localization to organelle 1115
              establishment of protein localization to organelle 531
                establishment of protein localization to vacuole 77
                  protein targeting to vacuole 59
                    cytoplasm to vacuole targeting by the NVT pathway 0
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