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ONTOLOGY REPORT - ANNOTATIONS


Term:cytoplasm to vacuole transport by the NVT pathway
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Accession:GO:0120113 term browser browse the term
Definition:A pathway targeting soluble cytosolic proteins to the vacuole lumen. It uses a selective autophagy receptor protein Nbr1, which is an ortholog of mammalian NBR1, and is remotely related to S. cerevisiae Cvt pathway receptor protein Atg19. Similar to the Cvt pathway, the cargos transported by this pathway are hydrolases, which presumably contribute to the hydrolytic activities in the vacuole lumen. Different from the Cvt pathway, this pathway does not require the macroautophagy machinery, but instead relies on the ESCRT machinery for cargo sequestration. This pathway is observed in the fission yeast S. pombe.
Synonyms:exact_synonym: protein localization by the NVT pathway;   protein localization by the Nbr1-mediated vacuolar targeting pathway
 broad_synonym: cytoplasm to vacuole targeting


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Path 1
Term Annotations click to browse term
  biological_process 20014
    cellular process 18788
      vacuolar transport 156
        protein targeting to vacuole 44
          cytoplasm to vacuole transport by the NVT pathway 0
Path 2
Term Annotations click to browse term
  biological_process 20014
    localization 6486
      establishment of localization 4918
        transport 4774
          nitrogen compound transport 2181
            amide transport 1841
              peptide transport 1807
                protein transport 1749
                  intracellular protein transport 1013
                    protein targeting 323
                      protein targeting to vacuole 44
                        cytoplasm to vacuole transport by the NVT pathway 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.