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ONTOLOGY REPORT - ANNOTATIONS

Term:RNA NAD+-cap (NAD+-forming) hydrolase activity
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Accession:GO:0110152 term browser browse the term
Definition:Catalysis of the reaction: a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H+ + NAD+.
Comment:This reaction specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
Synonyms:xref: RHEA:60880


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RNA NAD+-cap (NAD+-forming) hydrolase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DXO decapping exoribonuclease enables ISO (MGI:6368104|PMID:28283058), (MGI:6716974|PMID:32374864)
(PMID:28283058), (PMID:32374864)		 UniProt PMID:28283058 PMID:32374864 MGI:6368104 MGI:6716974 NCBI chr12:1,424,584...1,426,275
Ensembl chr12:1,424,591...1,426,452 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18563
    catalytic activity 5534
      catalytic activity, acting on a nucleic acid 580
        catalytic activity, acting on RNA 355
          RNA NAD+-cap (NAD+-forming) hydrolase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 18563
    catalytic activity 5534
      hydrolase activity 2360
        hydrolase activity, acting on acid anhydrides 665
          hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 664
            RNA NAD+-cap (NAD+-forming) hydrolase activity 1
paths to the root