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ONTOLOGY REPORT - ANNOTATIONS

Term:carboxylesterase activity
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Accession:GO:0106435 term browser browse the term
Definition:Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H+.
Comment:Note: This covers a broad range of specificity; also hydrolyzes vitamin A esters.
Synonyms:narrow_synonym: B-esterase activity;   alpha-carboxylesterase activity;   cocaine esterase;   procaine esterase;   serine esterase activity;   triacetin esterase;   vitamin A esterase
 related_synonym: ali-esterase activity;   nonspecific carboxylesterase activity
 xref: EC:3.1.1.1;   MetaCyc:CARBOXYLESTERASE-RXN;   RHEA:21164;   Reactome:R-HSA-9619024 "CES1trimer hydrolyses ACEI pro-drugs to ACEIs";   Reactome:R-HSA-9727567 "CES1 hydrolyses sacubitril to sacubitrilat";   Reactome:R-HSA-9749647 "CES2 hydrolyzes ASA-"


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carboxylesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member enables ISS
ISO		 GO_REF:0000024
(PMID:19506075)		 UniProt
RGD		 PMID:19506075 GO_REF:0000024 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Ces1c carboxylesterase 1C IDA RGD PMID:3360755 RGD:155630594 NCBI chr19:13,926,401...13,955,527
Ensembl chr19:13,926,260...13,955,524 		JBrowse link
G Ces1d carboxylesterase 1D enables ISO (PMID:18762277), (PMID:8218228)
MGI:4440967 (PMID:20197051)		 RGD PMID:8218228 PMID:18762277 PMID:20197051 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Ces1e carboxylesterase 1E enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr19:13,833,154...13,869,627
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Ces1f carboxylesterase 1F enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr19:13,796,623...13,822,113
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Ces2a carboxylesterase 2A IDA RGD PMID:12230550 RGD:724430 NCBI chr19:129,428...136,480
Ensembl chr19:129,428...136,480 		JBrowse link
G Ces2e carboxylesterase 2E enables ISO (PMID:15123619) RGD PMID:15123619 NCBI chr19:157,447...172,822
Ensembl chr19:157,407...172,856 		JBrowse link
G Ces2el1 carboxylesterase 2E like 1 enables IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr19:28,516...37,772
Ensembl chr19:28,520...37,732 		JBrowse link
G Ces2h carboxylesterase 2H enables ISO (PMID:21049984) RGD PMID:21049984 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Ces5a carboxylesterase 5A enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr19:11,469,431...11,499,007
Ensembl chr19:11,469,469...11,499,006 		JBrowse link
G Cesl1 carboxylesterase-like 1 enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr19:22,670,709...23,006,329
Ensembl chr19:22,670,712...22,712,608 		JBrowse link
G LOC679368 similar to carboxylesterase 5 enables IEA GO_REF:0000107 Ensembl GO_REF:0000107
G Tnfaip6 TNF alpha induced protein 6 enables ISO (PMID:16873769), (PMID:20463016) RGD PMID:16873769 PMID:20463016 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 20733
    catalytic activity 6109
      hydrolase activity 2595
        hydrolase activity, acting on ester bonds 811
          carboxylic ester hydrolase activity 206
            carboxylesterase activity 13
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