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ONTOLOGY REPORT - ANNOTATIONS

Term:protein serine kinase activity
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Accession:GO:0106310 term browser browse the term
Definition:Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
Comment:Note that this term is to annotate proteins the specifically phosphorylate a serine residue on a protein. An example is human PIKFYVE (UniProt:Q9Y2I7). For dual specificity protein kinases, use 'protein serine/threonine kinase activity' ; GO:0004712.
Synonyms:xref: RHEA:17989;   Reactome:R-HSA-9729330 "SRPK1/2 phosphorylates nucleoprotein";   Reactome:R-HSA-9821967 "SRPK1 phosphorylates PRM2 in PRM2:dsDNA";   Reactome:R-HSA-9821982 "SRPK1 phosphorylates PRM1 in PRM1:dsDNA";   Reactome:R-HSA-9841265 "p-S473-AKT1 phosphorylates ESR1 on serine-167";   Reactome:R-HSA-9860792 "Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177";   Reactome:R-HSA-9860808 "p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179"

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protein serine kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 enables ISO (PMID:11784871) MGI PMID:11784871 NCBI chrNW_004624734:507,880...525,295
Ensembl chrNW_004624734:509,368...525,295 		JBrowse link
G Cdc42bpa CDC42 binding protein kinase alpha enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624771:12,314,566...12,591,071
Ensembl chrNW_004624771:12,314,570...12,591,015 		JBrowse link
G Cit citron rho-interacting serine/threonine kinase enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624747:13,749,126...13,918,222
Ensembl chrNW_004624747:13,750,283...13,915,715 		JBrowse link
G Csnk1d casein kinase 1 delta enables ISO (PMID:19043076)
(PMID:12270943), (PMID:16618118), (PMID:21084295) 		UniProt PMID:12270943 PMID:16618118 PMID:19043076 PMID:21084295 NCBI chrNW_004624801:11,031,102...11,074,100
Ensembl chrNW_004624801:11,032,021...11,058,551 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 enables IEA UniProt GO_REF:0000104 NCBI chrNW_004624741:1,566,380...1,635,365 JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 enables IEA UniProt GO_REF:0000104 NCBI chrNW_004624746:28,012,543...28,064,610
Ensembl chrNW_004624746:28,012,556...28,060,413 		JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A enables ISO (PMID:25556849), (PMID:30773093) UniProt PMID:25556849 PMID:30773093 NCBI chrNW_004624745:26,180,858...26,316,848
Ensembl chrNW_004624745:26,180,864...26,315,234 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624731:28,178,647...28,368,784
Ensembl chrNW_004624731:28,178,628...28,366,420 		JBrowse link
G Lats2 large tumor suppressor kinase 2 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624776:16,572,598...16,640,412
Ensembl chrNW_004624776:16,585,025...16,638,520 		JBrowse link
G Map3k10 mitogen-activated protein kinase kinase kinase 10 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624925:232,397...250,083
Ensembl chrNW_004624925:232,986...249,794 		JBrowse link
G Map4k1 mitogen-activated protein kinase kinase kinase kinase 1 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624794:12,004,536...12,025,430
Ensembl chrNW_004624794:12,004,643...12,024,364 		JBrowse link
G Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624738:20,716,430...20,874,930
Ensembl chrNW_004624738:20,715,296...20,875,393 		JBrowse link
G Map4k5 mitogen-activated protein kinase kinase kinase kinase 5 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624731:18,362,856...18,460,761 JBrowse link
G Mapk1 mitogen-activated protein kinase 1 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624747:1,296,062...1,389,674
Ensembl chrNW_004624747:1,296,221...1,389,757 		JBrowse link
G Mapk10 mitogen-activated protein kinase 10 enables IEA UniProt GO_REF:0000104 NCBI chrNW_004624872:2,460,308...2,830,569
Ensembl chrNW_004624872:2,461,362...2,825,161 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624752:502,411...508,452
Ensembl chrNW_004624752:502,350...508,449 		JBrowse link
G Mapk12 mitogen-activated protein kinase 12 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624752:510,593...518,065
Ensembl chrNW_004624752:510,601...518,065 		JBrowse link
G Mapk13 mitogen-activated protein kinase 13 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624754:21,506,086...21,513,803
Ensembl chrNW_004624754:21,506,369...21,513,801 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624849:5,655,631...5,661,779
Ensembl chrNW_004624849:5,656,515...5,664,721 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 enables IEA UniProt GO_REF:0000104 NCBI chrNW_004624928:1,442,216...1,494,275
Ensembl chrNW_004624928:1,439,146...1,494,266 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 enables IEA UniProt GO_REF:0000104 NCBI chrNW_004624733:42,998,948...43,048,392
Ensembl chrNW_004624733:42,999,339...43,048,285 		JBrowse link
G Mark2 microtubule affinity regulating kinase 2 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624767:22,346,467...22,419,325 JBrowse link
G Mark3 microtubule affinity regulating kinase 3 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624734:1,362,263...1,469,930 JBrowse link
G Mark4 microtubule affinity regulating kinase 4 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624907:2,184,702...2,212,673
Ensembl chrNW_004624907:2,184,729...2,212,666 		JBrowse link
G Melk maternal embryonic leucine zipper kinase enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624930:247,018...333,240 JBrowse link
G Mos MOS proto-oncogene, serine/threonine kinase ISO RGD PMID:9001211 RGD:596933305 NCBI chrNW_004624886:3,934,081...3,935,341
Ensembl chrNW_004624886:3,934,192...3,935,220 		JBrowse link
G Nlk nemo like kinase enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624786:763,857...910,077
Ensembl chrNW_004624786:763,819...904,188 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta enables ISO (PMID:12502714) UniProt PMID:12502714 NCBI chrNW_004624730:15,226,786...15,399,097
Ensembl chrNW_004624730:15,226,379...15,355,857 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma enables ISO (PMID:12502714) UniProt PMID:12502714 NCBI chrNW_004624739:22,737,376...22,772,696
Ensembl chrNW_004624739:22,737,270...22,772,589 		JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase enables IEA UniProt GO_REF:0000104 NCBI chrNW_004624754:20,810,398...20,815,182
Ensembl chrNW_004624754:20,808,701...20,815,206 		JBrowse link
G Pim2 Pim-2 proto-oncogene, serine/threonine kinase enables IEA UniProt GO_REF:0000104 NCBI chrNW_004624893:694,944...700,068
Ensembl chrNW_004624893:694,928...700,062 		JBrowse link
G Pim3 Pim-3 proto-oncogene, serine/threonine kinase enables IEA UniProt GO_REF:0000104 NCBI chrNW_004624752:710,959...715,035
Ensembl chrNW_004624752:710,960...715,342 		JBrowse link
G Pink1 PTEN induced kinase 1 enables ISO (PMID:32484300) UniProt PMID:32484300 NCBI chrNW_004624764:5,656,207...5,671,260
Ensembl chrNW_004624764:5,656,229...5,671,260 		JBrowse link
G Plk1 polo like kinase 1 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624782:8,811,593...8,823,060
Ensembl chrNW_004624782:8,811,616...8,826,749 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624759:14,143,439...14,174,971
Ensembl chrNW_004624759:14,142,956...14,171,718 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624862:3,443,720...3,496,078
Ensembl chrNW_004624862:3,450,078...3,496,142 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha enables ISO (PMID:22797923) UniProt PMID:22797923 NCBI chrNW_004624901:1,319,426...1,336,848
Ensembl chrNW_004624901:1,319,062...1,336,744 		JBrowse link
G Prkca protein kinase C alpha enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624870:1,589,775...2,023,160
Ensembl chrNW_004624870:1,596,102...2,023,172 		JBrowse link
G Prkcd protein kinase C delta enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624822:4,035,819...4,062,907
Ensembl chrNW_004624822:4,033,130...4,059,555 		JBrowse link
G Prkcq protein kinase C theta enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624775:1,419,596...1,543,805
Ensembl chrNW_004624775:1,419,509...1,502,064 		JBrowse link
G Prkd1 protein kinase D1 enables ISO (PMID:20497126) BHF-UCL PMID:20497126 NCBI chrNW_004624820:2,408,562...2,726,199
Ensembl chrNW_004624820:2,408,360...2,726,606 		JBrowse link
G Prkd2 protein kinase D2 enables ISO (PMID:20497126) BHF-UCL PMID:20497126 NCBI chrNW_004624832:6,885,627...6,915,316
Ensembl chrNW_004624832:6,886,327...6,915,179 		JBrowse link
G Prkg2 protein kinase cGMP-dependent 2 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624757:9,799,777...9,904,825
Ensembl chrNW_004624757:9,798,808...9,906,517 		JBrowse link
G Riok1 RIO kinase 1 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624756:18,159,985...18,185,995
Ensembl chrNW_004624756:18,159,353...18,185,758 		JBrowse link
G Ripk4 receptor interacting serine/threonine kinase 4 enables ISO (PMID:28507225) UniProt PMID:28507225 NCBI chrNW_004624745:28,461,948...28,481,721
Ensembl chrNW_004624745:28,461,900...28,481,813 		JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624764:10,527,012...10,566,625
Ensembl chrNW_004624764:10,526,948...10,569,910 		JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624785:12,450,686...12,839,563
Ensembl chrNW_004624785:12,657,845...12,839,569 		JBrowse link
G Rps6ka4 ribosomal protein S6 kinase A4 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624767:21,958,940...21,970,998
Ensembl chrNW_004624767:21,958,868...21,971,108 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624734:11,499,372...11,660,564
Ensembl chrNW_004624734:11,499,637...11,659,536 		JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624767:19,090,090...19,097,123
Ensembl chrNW_004624767:19,090,067...19,096,689 		JBrowse link
G Sik2 salt inducible kinase 2 enables ISO (PMID:24129571)
(PMID:21084751) 		UniProt
MGI		 PMID:21084751 PMID:24129571 NCBI chrNW_004624784:6,728,504...6,900,557
Ensembl chrNW_004624784:6,745,595...6,895,747 		JBrowse link
G Stk38l serine/threonine kinase 38 like enables IEA RHEA GO_REF:0000116 NCBI chrNW_004624750:50,591...134,481 JBrowse link
G Tbk1 TANK binding kinase 1 enables ISO (PMID:22412986) BHF-UCL PMID:22412986 NCBI chrNW_004624802:3,861,821...3,914,061
Ensembl chrNW_004624802:3,862,709...3,914,028 		JBrowse link
G Ttbk1 tau tubulin kinase 1 enables ISO (PMID:30556160) ARUK-UCL PMID:30556160 NCBI chrNW_004624754:16,288,172...16,322,794
Ensembl chrNW_004624754:16,290,613...16,320,070 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18443
    catalytic activity 5677
      catalytic activity, acting on a protein 2240
        protein kinase activity 589
          protein serine kinase activity 54
            [isocitrate dehydrogenase (NADP+)] kinase activity 0
Path 2
Term Annotations click to browse term
  molecular_function 18443
    catalytic activity 5677
      transferase activity 2404
        transferase activity, transferring phosphorus-containing groups 1028
          kinase activity 868
            protein kinase activity 589
              protein serine kinase activity 54
                [isocitrate dehydrogenase (NADP+)] kinase activity 0
paths to the root