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ONTOLOGY REPORT - ANNOTATIONS


Term:mCRD-mediated mRNA stability complex
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Accession:GO:0106002 term browser browse the term
Definition:A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP.
Comment:This complex is related to GO:0070937 CRD-mediated mRNA stability complex but binds the major protein-coding-region determinant of instability (mCRD) domain rather than the CRD. Experimentally it has been shown to act on c-FOS mRNA while GO:0070937 acts on c-MYC mRNA.
Synonyms:exact_synonym: mCRD-poly(A)-bridging complex;   major coding region determinant of instability-mediated mRNA stability complex;   major coding region instability determinant-mediated mRNA stability complex;   major coding region instability determinant-poly(A)-bridging complex;   major coding-region determinant of instability - poly(A) tail-bridging complex



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mCRD-mediated mRNA stability complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csde1 cold shock domain containing E1 located_in ISO (PMID:11051545) RGD PMID:11051545 NCBI chr 2:190,546,015...190,582,790
Ensembl chr 2:190,554,980...190,582,784
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D located_in ISO (PMID:11051545) RGD PMID:11051545 NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786
JBrowse link
G Pabpc1 poly(A) binding protein, cytoplasmic 1 located_in ISO (PMID:11051545) RGD PMID:11051545 NCBI chr 7:67,777,438...67,789,731
Ensembl chr 7:67,777,381...67,789,744
JBrowse link
G Paip1 poly(A) binding protein interacting protein 1 located_in ISO (PMID:11051545) RGD PMID:11051545 NCBI chr 2:51,523,142...51,550,241
Ensembl chr 2:51,522,921...51,550,241
JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein located_in
part_of
ISO
IEA
(PMID:11051545)
GO_REF:0000107
RGD
Ensembl
PMID:11051545 GO_REF:0000107 NCBI chr 8:89,402,487...89,435,517
Ensembl chr 8:89,402,866...89,435,515
JBrowse link

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  cellular_component 19187
    protein-containing complex 5925
      mCRD-mediated mRNA stability complex 5
Path 2
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  cellular_component 19187
    cellular anatomical entity 18928
      intracellular anatomical structure 14074
        cytoplasm 11200
          cytosol 4180
            mCRD-mediated mRNA stability complex 5
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