Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:mCRD-mediated mRNA stability complex
go back to main search page
Accession:GO:0106002 term browser browse the term
Definition:A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP.
Comment:This complex is related to GO:0070937 CRD-mediated mRNA stability complex but binds the major protein-coding-region determinant of instability (mCRD) domain rather than the CRD. Experimentally it has been shown to act on c-FOS mRNA while GO:0070937 acts on c-MYC mRNA.
Synonyms:exact_synonym: mCRD-poly(A)-bridging complex;   major coding region determinant of instability-mediated mRNA stability complex;   major coding region instability determinant-mediated mRNA stability complex;   major coding region instability determinant-poly(A)-bridging complex;   major coding-region determinant of instability - poly(A) tail-bridging complex
 xref: IntAct:EBI-13948957


show annotations for term's descendants           Sort by:
 

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20126
    protein-containing complex 6038
      mCRD-mediated mRNA stability complex 0
Path 2
Term Annotations click to browse term
  cellular_component 20126
    cellular anatomical entity 19825
      intracellular anatomical structure 14390
        cytoplasm 11380
          cytosol 4232
            mCRD-mediated mRNA stability complex 0
paths to the root