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ONTOLOGY REPORT - ANNOTATIONS

Term:ligand-gated calcium channel activity
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Accession:GO:0099604 term browser browse the term
Definition:Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.


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ligand-gated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mcoln1 mucolipin TRP cation channel 1 enables ISO (PMID:29019983) RGD PMID:29019983 NCBI chr12:1,560,341...1,574,252
Ensembl chr12:1,560,359...1,574,252 		JBrowse link
G P2rx4 purinergic receptor P2X 4 enables ISO
IMP		 (PMID:9016352)
PMID:17299767		 RGD PMID:9016352 PMID:17299767 RGD:13673751 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253 		JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 enables IBA
ISS
ISO		 PMID:21873635
GO_REF:0000024
(PMID:19171771), (PMID:25620041), (PMID:27333281), (PMID:28775320), (PMID:29745897), (PMID:30467180)
(MGI:5298324|PMID:21753080)		 UniProt
RGD		 PMID:19171771 PMID:21753080 PMID:25620041 PMID:27333281 PMID:28775320 More... GO_REF:0000024 MGI:5298324, RGD:13792537 NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532 		JBrowse link
G Trpm5 transient receptor potential cation channel, subfamily M, member 5 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:198,254,956...198,277,824
Ensembl chr 1:198,255,723...198,277,654 		JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:88,897,039...88,990,167
Ensembl chr 9:88,903,880...88,988,552 		JBrowse link
calcium-induced calcium release activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENSRNOG00000067970 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 3:99,631,867...99,979,128 JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel enables ISO (PMID:11854751) RGD PMID:11854751 NCBI chr14:5,237,135...5,280,455
Ensembl chr14:5,237,135...5,280,825 		JBrowse link
G Ryr1 ryanodine receptor 1 enables IBA
IEA
ISO		 PMID:21873635
GO_REF:0000107
(PMID:26115329)		 Ensembl
RGD		 PMID:26115329 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 1:84,292,578...84,423,799
Ensembl chr 1:84,292,578...84,423,812 		JBrowse link
G Ryr2 ryanodine receptor 2 enables IDA
IBA
ISO
IEA		 PMID:21873635
(PMID:17921453)
GO_REF:0000107		 RGD
Ensembl		 PMID:17921453 PMID:18799678 PMID:21873635 GO_REF:0000107, RGD:7175259, RGD:13792537 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Ryr3 ryanodine receptor 3 IDA RGD PMID:18799678 RGD:7175259 NCBI chr 3:99,431,755...99,979,125
Ensembl chr 3:99,432,505...99,704,961 		JBrowse link
calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 enables ISS
ISO		 GO_REF:0000024
(MGI:4944154|PMID:20813840)		 UniProt
RGD		 PMID:20813840 GO_REF:0000024 MGI:4944154 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 enables ISO (MGI:68044|PMID:8063813) RGD PMID:8063813 MGI:68044 NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164 		JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 enables ISS
ISO		 GO_REF:0000024
(MGI:4944154|PMID:20813840)		 UniProt
RGD		 PMID:20813840 GO_REF:0000024 MGI:4944154 NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337 		JBrowse link
G Rasa3 RAS p21 protein activator 3 enables ISO
IEA		 (PMID:10828023)
GO_REF:0000107		 RGD
Ensembl		 PMID:10828023 GO_REF:0000107 NCBI chr16:75,855,360...75,969,349
Ensembl chr16:75,855,265...75,970,804 		JBrowse link
G Ryr2 ryanodine receptor 2 enables ISO
ISS		 (PMID:17921453)
(MGI:1345009|PMID:10473538)
GO_REF:0000024		 RGD
UniProt		 PMID:10473538 PMID:17921453 GO_REF:0000024 MGI:1345009 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Ryr3 ryanodine receptor 3 enables ISO (PMID:9395096) RGD PMID:9395096 NCBI chr 3:99,431,755...99,979,125
Ensembl chr 3:99,432,505...99,704,961 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 enables ISO
ISS
IEA		 (PMID:20547126), (PMID:25855297)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:20547126 PMID:25855297 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 enables ISO
ISS		 (PMID:27068538)
GO_REF:0000024		 RGD
UniProt		 PMID:27068538 GO_REF:0000024 NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 enables IMP PMID:17582331 UniProt PMID:17582331 RGD:8553505 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
glutamate-gated calcium ion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 enables ISO (PMID:26875626) RGD PMID:26875626 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A enables IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:26875626), (PMID:27839871)		 Ensembl
UniProt
RGD		 PMID:26875626 PMID:27839871 GO_REF:0000024 GO_REF:0000107 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B enables IEA
ISO
ISS		 GO_REF:0000107
(PMID:26875626), (PMID:27839871)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:26875626 PMID:27839871 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C enables ISS
ISO
IEA		 GO_REF:0000024
(PMID:26875626)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:26875626 GO_REF:0000024 GO_REF:0000107 NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427 		JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D enables ISO
ISS		 (PMID:26875626)
GO_REF:0000024		 RGD
UniProt		 PMID:26875626 GO_REF:0000024 NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793 		JBrowse link
inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 enables ISO (MGI:6202152|PMID:11117745) RGD PMID:11117745 MGI:6202152 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 enables IDA
IEA
ISO
IBA
ISS		 GO_REF:0000117
(MGI:3709705|PMID:17327232), (MGI:4944154|PMID:20813840)
PMID:21873635
GO_REF:0000024		 UniProt
RGD		 PMID:17327232 PMID:20813840 PMID:19036964 PMID:21873635 PMID:15533917 GO_REF:0000024 GO_REF:0000117 MGI:3709705 MGI:4944154, RGD:6480876, RGD:13792537, RGD:7175271 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 enables IDA
IEA
ISO
IMP
IBA		 GO_REF:0000117
(MGI:3709705|PMID:17327232), (MGI:68044|PMID:8063813)
PMID:23166348
PMID:21873635		 UniProt
RGD		 PMID:8063813 PMID:17327232 PMID:15533917 PMID:23166348 PMID:21873635 More... GO_REF:0000117 MGI:3709705 MGI:68044, RGD:7175271, RGD:12790654, RGD:13792537, RGD:7175277 NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164 		JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 enables TAS
IEA
ISO
IBA
ISS
IDA		 GO_REF:0000117
(MGI:3589715|PMID:15890645), (MGI:3709705|PMID:17327232), (MGI:4944154|PMID:20813840)
PMID:21873635
GO_REF:0000024
(PMID:10828023)		 UniProt
RGD		 PMID:10828023 PMID:15890645 PMID:17327232 PMID:20813840 PMID:11788349 More... GO_REF:0000024 GO_REF:0000117 MGI:3589715 MGI:3709705 MGI:4944154, RGD:619539, RGD:13792537, RGD:7175271, RGD:7175268, RGD:7175265, RGD:2290285 NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337 		JBrowse link
NAADP-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mcoln1 mucolipin TRP cation channel 1 enables IDA
IBA		 PMID:21873635 RGD
GO_Central		 PMID:17613490 PMID:21873635 RGD:7205504, RGD:13792537 NCBI chr12:1,560,341...1,574,252
Ensembl chr12:1,560,359...1,574,252 		JBrowse link
G Mcoln2 mucolipin TRP cation channel 2 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:235,053,816...235,102,703
Ensembl chr 2:235,053,816...235,102,702 		JBrowse link
G Mcoln3 mucolipin TRP cation channel 3 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:234,966,010...235,043,047
Ensembl chr 2:234,966,010...235,043,047 		JBrowse link
G Tpcn1 two pore segment channel 1 enables
NOT|enables		 ISS
ISO
IEA		 GO_REF:0000024
(MGI:6718238|PMID:24776928)
(PMID:24776928)
GO_REF:0000107
(PMID:19620632)		 UniProt
RGD
Ensembl		 PMID:19620632 PMID:24776928 GO_REF:0000024 GO_REF:0000107 MGI:6718238 NCBI chr12:35,972,813...36,029,632
Ensembl chr12:35,972,846...36,029,626 		JBrowse link
G Tpcn2 two pore segment channel 2 enables
NOT|enables		 ISO (PMID:19387438), (PMID:19620632), (PMID:20880839), (PMID:32167471)
(MGI:5285159|PMID:20495006), (MGI:5285171|PMID:19557428), (MGI:5691857|PMID:25144390)
(PMID:23063126)		 RGD PMID:19387438 PMID:19557428 PMID:19620632 PMID:20495006 PMID:20880839 More... MGI:5285159 MGI:5285171 MGI:5691857 NCBI chr 1:200,416,538...200,446,252
Ensembl chr 1:200,416,540...200,446,236 		JBrowse link
ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ryr1 ryanodine receptor 1 enables IDA
IEA
ISO
ISS		 GO_REF:0000002
(MGI:74313|PMID:7621815)
GO_REF:0000024
PMID:19116207
(PMID:11741831), (PMID:16163667), (PMID:22480578), (PMID:26115329)
GO_REF:0000107
PMID:11316255		 InterPro
RGD
UniProt
Ensembl		 PMID:7621815 PMID:11741831 PMID:16163667 PMID:22480578 PMID:26115329 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 MGI:74313, RGD:7175256, RGD:7242196, RGD:12903237 NCBI chr 1:84,292,578...84,423,799
Ensembl chr 1:84,292,578...84,423,812 		JBrowse link
G Ryr2 ryanodine receptor 2 enables IMP
ISO
IEA
IDA		 (PMID:15041652)
(MGI:3027171|PMID:14593104), (MGI:3713015|PMID:17431507)
(PMID:17921453)
GO_REF:0000107
GO_REF:0000002		 RGD
Ensembl
InterPro		 PMID:14593104 PMID:15041652 PMID:17431507 PMID:17921453 PMID:21807619 More... GO_REF:0000002 GO_REF:0000107 MGI:3027171 MGI:3713015, RGD:7175254, RGD:7175259 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Ryr3 ryanodine receptor 3 IDA RGD PMID:18799678 RGD:7175259 NCBI chr 3:99,431,755...99,979,125
Ensembl chr 3:99,432,505...99,704,961 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20780
    transporter activity 1253
      transmembrane transporter activity 1153
        ion transmembrane transporter activity 879
          ion channel activity 455
            cation channel activity 350
              calcium channel activity 121
                ligand-gated calcium channel activity 26
                  calcium-release channel activity + 17
                  glutamate-gated calcium ion channel activity 5
Path 2
Term Annotations click to browse term
  molecular_function 20780
    transporter activity 1253
      transmembrane transporter activity 1153
        ion transmembrane transporter activity 879
          cation transmembrane transporter activity 673
            inorganic cation transmembrane transporter activity 626
              metal ion transmembrane transporter activity 445
                calcium ion transmembrane transporter activity 139
                  calcium channel activity 121
                    ligand-gated calcium channel activity 26
                      calcium-release channel activity + 17
                      glutamate-gated calcium ion channel activity 5
paths to the root