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ONTOLOGY REPORT - ANNOTATIONS

Term:neuronal dense core vesicle exocytosis
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Accession:GO:0099011 term browser browse the term
Definition:The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a neuronal dense core vesicle by fusion of the granule with the plasma membrane of a neuron in response to increased cytosolic calcium levels.

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neuronal dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103219228 protein unc-13 homolog B involved_in ISO (MGI:5476894|PMID:23229896)
(PMID:23229896)		 UniProt PMID:23229896 MGI:5476894 NCBI chr12:45,230,661...45,461,934
Ensembl chr12:45,230,659...45,461,339 		JBrowse link
G UNC13A unc-13 homolog A involved_in ISO (MGI:5476894|PMID:23229896) UniProt PMID:23229896 MGI:5476894 NCBI chr 6:16,082,703...16,167,165
Ensembl chr 6:16,084,168...16,154,812 		JBrowse link
postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT6 synaptotagmin 6 involved_in ISO PMID:26216953 SynGO PMID:26216953 RGD:13702162 NCBI chr20:19,497,218...19,561,621
Ensembl chr20:19,512,540...19,563,038 		JBrowse link
presynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CADPS calcium dependent secretion activator involved_in ISO (MGI:5634021|PMID:25719439)
(PMID:25719439)		 SynGO PMID:25719439 MGI:5634021 NCBI chr22:23,471,616...23,948,694 JBrowse link
G LOC103219228 protein unc-13 homolog B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr12:45,230,661...45,461,934
Ensembl chr12:45,230,659...45,461,339 		JBrowse link
G RIMS1 regulating synaptic membrane exocytosis 1 involved_in ISO (PMID:31679900) SynGO PMID:31679900 NCBI chr17:2,690,430...3,176,794
Ensembl chr17:2,690,418...3,176,738 		JBrowse link
G SNAP25 synaptosome associated protein 25 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:27,857,093...27,944,487
Ensembl chr 2:27,858,319...27,944,496 		JBrowse link
G STXBP1 syntaxin binding protein 1 involved_in ISO (MGI:3621672|PMID:11545717) SynGO PMID:11545717 MGI:3621672 NCBI chr12:10,440,061...10,519,798
Ensembl chr12:10,439,801...10,519,777 		JBrowse link
G SYT10 synaptotagmin 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:32,846,425...32,914,946
Ensembl chr11:32,850,902...32,914,464 		JBrowse link
G UNC13A unc-13 homolog A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:16,082,703...16,167,165
Ensembl chr 6:16,084,168...16,154,812 		JBrowse link
G UNC13C unc-13 homolog C involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr26:28,806,368...29,196,031 JBrowse link
regulation of postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT4 synaptotagmin 4 involved_in ISO (PMID:19448629) SynGO PMID:19448629 NCBI chr18:37,595,187...37,604,931
Ensembl chr18:37,595,035...37,606,007 		JBrowse link
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103219228 protein unc-13 homolog B involved_in ISO PMID:31679900 SynGO PMID:31679900 RGD:155230690 NCBI chr12:45,230,661...45,461,934
Ensembl chr12:45,230,659...45,461,339 		JBrowse link
G P2RX7 purinergic receptor P2X 7 involved_in ISO PMID:24037803 SynGO PMID:24037803 RGD:13702177 NCBI chr11:116,505,975...116,560,151
Ensembl chr11:116,529,346...116,563,059 		JBrowse link
G RAB11B RAB11B, member RAS oncogene family involved_in ISO PMID:14627637 SynGO PMID:14627637 RGD:8554199 NCBI chr 6:7,743,130...7,757,237
Ensembl chr 6:7,743,361...7,757,305 		JBrowse link
G RAB3A RAB3A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:16,671,388...16,678,780
Ensembl chr 6:16,670,431...16,678,644 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17098
    localization 5436
      organelle localization 632
        vesicle localization 205
          establishment of vesicle localization 181
            dense core granule exocytosis 16
              neuronal dense core vesicle exocytosis 13
                postsynaptic dense core vesicle exocytosis + 2
                presynaptic dense core vesicle exocytosis + 11
Path 2
Term Annotations click to browse term
  biological_process 17098
    localization 5436
      establishment of localization 4717
        transport 4414
          secretion 1151
            secretion by cell 986
              exocytosis 392
                regulated exocytosis 271
                  calcium-ion regulated exocytosis 78
                    dense core granule exocytosis 16
                      neuronal dense core vesicle exocytosis 13
                        postsynaptic dense core vesicle exocytosis + 2
                        presynaptic dense core vesicle exocytosis + 11
paths to the root