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ONTOLOGY REPORT - ANNOTATIONS

Term:neuronal dense core vesicle exocytosis
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Accession:GO:0099011 term browser browse the term
Definition:The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a neuronal dense core vesicle by fusion of the granule with the plasma membrane of a neuron in response to increased cytosolic calcium levels.


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neuronal dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CADPS calcium dependent secretion activator ISO RGD PMID:30893606 RGD:616473719 NCBI chr 3:62,321,496...62,797,298 JBrowse link
G UNC13A unc-13 homolog A involved_in ISO (PMID:23229896) UniProt
RGD		 PMID:23229896 PMID:31467284 RGD:616473717 NCBI chr19:17,088,654...17,175,559
Ensembl chr19:18,068,006...18,150,642 		JBrowse link
G UNC13B unc-13 homolog B involved_in ISO (PMID:23229896) UniProt PMID:23229896 NCBI chr 9:35,011,350...35,255,148
Ensembl chr 9:35,817,353...36,059,894 		JBrowse link
postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT6 synaptotagmin 6 involved_in ISO PMID:26216953 SynGO PMID:26216953 RGD:13702162 NCBI chr 1:88,397,809...88,467,493
Ensembl chr 1:123,452,889...123,514,795 		JBrowse link
presynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CADPS calcium dependent secretion activator involved_in ISO (PMID:25719439) SynGO PMID:25719439 NCBI chr 3:62,321,496...62,797,298 JBrowse link
G RIMS1 regulating synaptic membrane exocytosis 1 involved_in ISO (PMID:31679900) SynGO PMID:31679900 NCBI chr 6:69,714,807...70,231,260
Ensembl chr 6:73,008,176...73,523,422 		JBrowse link
G SNAP25 synaptosome associated protein 25 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:10,164,236...10,252,856
Ensembl chr20:10,218,358...10,252,841 		JBrowse link
G SYT10 synaptotagmin 10 involved_in ISO (PMID:28683263) SynGO PMID:28683263 NCBI chr12:52,761,294...52,830,221
Ensembl chr12:55,364,714...55,429,298 		JBrowse link
G UNC13A unc-13 homolog A involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:17,088,654...17,175,559
Ensembl chr19:18,068,006...18,150,642 		JBrowse link
G UNC13B unc-13 homolog B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:35,011,350...35,255,148
Ensembl chr 9:35,817,353...36,059,894 		JBrowse link
regulation of postsynaptic dense core vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT4 synaptotagmin 4 involved_in ISO (PMID:19448629) SynGO PMID:19448629 NCBI chr18:36,540,756...36,550,439
Ensembl chr18:40,089,938...40,099,721 		JBrowse link
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RX7 purinergic receptor P2X 7 involved_in ISO PMID:24037803 SynGO PMID:24037803 RGD:13702177 NCBI chr12:118,731,761...118,786,039
Ensembl chr12:122,102,888...122,154,068 		JBrowse link
G RAB11B RAB11B, member RAS oncogene family involved_in ISO PMID:14627637 SynGO PMID:14627637 RGD:8554199 NCBI chr19:7,676,095...7,690,177 JBrowse link
G RAB3A RAB3A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:17,672,661...17,679,541
Ensembl chr19:18,649,166...18,656,768 		JBrowse link
G UNC13B unc-13 homolog B involved_in ISO PMID:31679900 SynGO PMID:31679900 RGD:155230690 NCBI chr 9:35,011,350...35,255,148
Ensembl chr 9:35,817,353...36,059,894 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19472
    localization 5986
      organelle localization 614
        vesicle localization 199
          establishment of vesicle localization 177
            dense core granule exocytosis 15
              neuronal dense core vesicle exocytosis 11
                postsynaptic dense core vesicle exocytosis + 2
                presynaptic dense core vesicle exocytosis + 9
Path 2
Term Annotations click to browse term
  biological_process 19472
    localization 5986
      establishment of localization 5241
        transport 4389
          secretion 1155
            secretion by cell 986
              exocytosis 375
                regulated exocytosis 260
                  calcium-ion regulated exocytosis 77
                    dense core granule exocytosis 15
                      neuronal dense core vesicle exocytosis 11
                        postsynaptic dense core vesicle exocytosis + 2
                        presynaptic dense core vesicle exocytosis + 9
paths to the root