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ONTOLOGY REPORT - ANNOTATIONS

Term:HCN channel complex
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Accession:GO:0098855 term browser browse the term
Definition:A cation ion channel with a preference for K+ over Na+ ions, which is activated by membrane hyperpolarization, and consists of a tetramer of HCN family members. Some members of this family (HCN1, HCN2 and HCN4) are also activated when cAMP binds to their cyclic nucleotide binding domain (CNBD). Channel complexes of this family play an important role in the control of pacemaker activity in the heart.
Synonyms:exact_synonym: K/Na hyperpolarization-activated cyclic nucleotide-gated channel complex;   potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel complex
 narrow_synonym: HCN1 channel complex;   HCN2 channel complex;   HCN3 channel complex;   HCN4 channel complex;   K/Na hyperpolarization-activated channel 3 complex;   K/Na hyperpolarization-activated cyclic nucleotide-gated channel 1 complex;   K/Na hyperpolarization-activated cyclic nucleotide-gated channel 2 complex;   K/Na hyperpolarization-activated cyclic nucleotide-gated channel 4 complex;   potassium/sodium hyperpolarization-activated channel 3 complex;   potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 complex;   potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 complex;   potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 complex
 related_synonym: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 tetramer;   potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 tetramer
 alt_id: GO:1990746;   GO:1990759


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HCN channel complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 part_of ISO
ISS
IEA
IBA		 (PMID:28086084)
GO_REF:0000024
GO_REF:0000107
GO_REF:0000033		 RGD
UniProt
Ensembl
GO_Central		 PMID:28086084 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:49,495,771...49,899,983
Ensembl chr 2:49,495,771...49,899,774 		JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 part_of ISO
IEA
IBA		 (PMID:10228147)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:10228147 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:9,969,801...9,988,839
Ensembl chr 7:9,970,368...9,988,841 		JBrowse link
G Hcn3 hyperpolarization-activated cyclic nucleotide-gated potassium channel 3 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:174,551,861...174,567,459
Ensembl chr 2:174,551,680...174,565,966 		JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 part_of ISO
IEA
IBA		 (PMID:10228147), (PMID:16407510)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000118		 RGD
Ensembl
GO_Central
TreeGrafter		 PMID:10228147 PMID:16407510 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:59,222,206...59,259,626
Ensembl chr 8:59,221,653...59,259,639 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21254
    protein-containing complex 6911
      membrane protein complex 1445
        plasma membrane protein complex 652
          voltage-gated potassium channel complex 86
            HCN channel complex 4
Path 2
Term Annotations click to browse term
  cellular_component 21254
    cellular anatomical entity 21098
      membrane 10447
        membrane protein complex 1445
          transmembrane transporter complex 470
            monoatomic ion channel complex 338
              cation channel complex 207
                potassium channel complex 102
                  voltage-gated potassium channel complex 86
                    HCN channel complex 4
paths to the root