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ONTOLOGY REPORT - ANNOTATIONS


Term:modulation of excitatory postsynaptic potential
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Accession:GO:0098815 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.



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modulation of excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:189,434,854...189,716,120
Ensembl chr13:189,435,094...189,716,056
JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,701...142,937,123
JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 ISO RGD PMID:12597860 RGD:152995391 NCBI chr13:192,877,707...193,296,954
Ensembl chr13:192,877,606...193,294,952
JBrowse link
G GRIK2 glutamate ionotropic receptor kainate type subunit 2 ISO RGD PMID:12597860 RGD:152995391 NCBI chr 1:68,052,086...68,680,448
Ensembl chr 1:68,057,538...68,679,256
JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A ISO RGD PMID:34233182 RGD:401940191 NCBI chr 3:32,749,329...33,149,350
Ensembl chr 3:32,750,700...33,143,499
JBrowse link
G PCLO piccolo presynaptic cytomatrix protein ISO RGD PMID:31074746 RGD:41408338 NCBI chr 9:97,114,503...97,513,081
Ensembl chr 9:97,114,511...97,513,072
JBrowse link
G SH3GL1 SH3 domain containing GRB2 like 1, endophilin A2 ISO RGD PMID:22750032 RGD:13463484 NCBI chr 2:74,414,453...74,445,450
Ensembl chr 2:74,414,466...74,445,447
JBrowse link
G SLC8A2 solute carrier family 8 member A2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:6282180|PMID:29274751) ARUK-UCL
Ensembl
PMID:29274751 GO_REF:0000107 MGI:6282180 NCBI chr 6:53,201,477...53,236,489
Ensembl chr 6:53,201,485...53,236,513
JBrowse link
G SLC8A3 solute carrier family 8 member A3 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:6282180|PMID:29274751) ARUK-UCL
Ensembl
PMID:29274751 GO_REF:0000107 MGI:6282180 NCBI chr 7:93,643,609...93,797,483
Ensembl chr 7:93,643,618...93,796,917
JBrowse link
G TMEM108 transmembrane protein 108 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:74,524,122...74,556,327
Ensembl chr13:74,180,198...74,555,928
JBrowse link
G ZMYND8 zinc finger MYND-type containing 8 ISO RGD PMID:24117785 RGD:8554267 NCBI chr17:49,258,543...49,390,418
Ensembl chr17:49,258,542...49,390,399
JBrowse link
negative regulation of excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBLN1 cerebellin 1 precursor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:35,516,097...35,518,080
Ensembl chr 6:35,515,754...35,519,517
JBrowse link
G CELF4 CUGBP Elav-like family member 4 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5313512|PMID:21745337) MGI
Ensembl
PMID:21745337 GO_REF:0000107 MGI:5313512 NCBI chr 6:121,065,604...121,381,052
Ensembl chr 6:121,066,772...121,381,028
JBrowse link
G EIF4A3 eukaryotic translation initiation factor 4A3 ISO RGD PMID:17632064 RGD:10044262 NCBI chr12:2,285,679...2,311,750
Ensembl chr12:2,285,579...2,313,874
JBrowse link
G LOC100624109 neuroligin-4, X-linked involved_in ISO (PMID:19726642) BHF-UCL PMID:19726642 NCBI chr  X:2,701,397...3,103,824
NCBI chr  Y:1,645,491...1,946,441
JBrowse link
G LRRK2 leucine rich repeat kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:71,800,337...71,945,828
Ensembl chr 5:71,800,225...71,945,828
JBrowse link
G MTMR2 myotubularin related protein 2 involved_in ISO PMID:20410104 BHF-UCL PMID:20410104 RGD:8553482 NCBI chr 9:27,864,335...27,974,448
Ensembl chr 9:27,854,491...27,974,423
JBrowse link
G NLGN3 neuroligin 3 involved_in ISO (MGI:5286761|PMID:21808020) CACAO PMID:21808020 MGI:5286761 NCBI chr  X:57,174,506...57,204,770
Ensembl chr  X:57,176,103...57,201,461
JBrowse link
G NPY2R neuropeptide Y receptor Y2 ISO RGD PMID:12055128 RGD:1642608 NCBI chr 8:74,039,959...74,048,398
Ensembl chr 8:74,039,616...74,047,817
JBrowse link
G PLK2 polo like kinase 2 ISO RGD PMID:20802490 RGD:152995511 NCBI chr16:37,299,116...37,305,114
Ensembl chr16:37,299,119...37,305,114
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase ISO RGD PMID:19033459 RGD:10413844 NCBI chr 1:5,698,508...6,731,132
Ensembl chr 1:5,465,312...6,730,872
JBrowse link
G PTEN phosphatase and tensin homolog involved_in ISO (MGI:5320272|PMID:21411674) CACAO PMID:21411674 MGI:5320272 NCBI chr14:99,929,590...100,021,619 JBrowse link
G S1PR2 sphingosine-1-phosphate receptor 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2157237|PMID:11553273) MGI
Ensembl
PMID:11553273 GO_REF:0000107 MGI:2157237 NCBI chr 2:69,050,396...69,057,270
Ensembl chr 2:69,049,270...69,057,270
JBrowse link
G TMEM25 transmembrane protein 25 involved_in IEA Ensembl
TreeGrafter
GO_REF:0000107 GO_REF:0000118 NCBI chr 9:45,834,197...45,838,978
Ensembl chr 9:45,829,196...45,838,972
JBrowse link
negative regulation of mini excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYNE1 spectrin repeat containing nuclear envelope protein 1 ISO RGD PMID:24191017 RGD:13209020 NCBI chr 1:13,715,644...14,201,711 JBrowse link
positive regulation of excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein involved_in ISO (PMID:19118188) ARUK-UCL PMID:19118188 NCBI chr13:189,434,854...189,716,120
Ensembl chr13:189,435,094...189,716,056
JBrowse link
G BAIAP2 BAR/IMD domain containing adaptor protein 2 ISO RGD PMID:15758177 RGD:9684984 NCBI chr12:1,609,420...1,666,965
Ensembl chr12:1,603,540...1,670,075
JBrowse link
G CACNB3 calcium voltage-gated channel auxiliary subunit beta 3 ISO RGD PMID:22187436 RGD:13514092 NCBI chr 5:14,875,524...14,888,224
Ensembl chr 5:14,874,465...14,888,223
JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,701...142,937,123
JBrowse link
G CUX2 cut like homeobox 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:32,311,781...32,587,194
Ensembl chr14:32,311,188...32,587,203
JBrowse link
G DBN1 drebrin 1 ISO RGD PMID:19174472 RGD:10398809 NCBI chr 2:80,480,603...80,495,797
Ensembl chr 2:80,479,460...80,495,796
JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 involved_in ISO PMID:12930820 BHF-UCL PMID:12930820 RGD:8554754 NCBI chr12:52,550,138...52,574,021
Ensembl chr12:52,550,141...52,575,143
JBrowse link
G DRD4 dopamine receptor D4 ISO RGD PMID:21622557 RGD:7248611 NCBI chr 2:398,766...401,539
Ensembl chr 2:398,766...402,433
JBrowse link
G DVL1 dishevelled segment polarity protein 1 involved_in ISO PMID:21670302 ParkinsonsUK-UCL PMID:21670302 RGD:10449514 NCBI chr 6:63,617,787...63,628,965
Ensembl chr 6:63,617,789...63,628,913
JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 involved_in ISO PMID:12930820
PMID:19793963
PMID:22246434
BHF-UCL
ComplexPortal
PMID:12930820 PMID:19793963 PMID:22246434 RGD:150521639 RGD:150521643 RGD:8554754
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A involved_in ISO PMID:12930820
PMID:22246434
BHF-UCL
ComplexPortal
RGD
PMID:12930820 PMID:22246434 PMID:29339324 RGD:150521639 RGD:401940161 RGD:8554754 NCBI chr 3:32,749,329...33,149,350
Ensembl chr 3:32,750,700...33,143,499
JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B involved_in ISO PMID:19793963 ComplexPortal
RGD
PMID:19793963 PMID:29339324 RGD:150521643 RGD:401940161 NCBI chr 5:58,477,862...58,948,735
Ensembl chr 5:58,480,528...58,927,558
JBrowse link
G GRIN2C glutamate ionotropic receptor NMDA type subunit 2C involved_in ISO PMID:19793963 ComplexPortal PMID:19793963 RGD:150521643 NCBI chr12:6,385,407...6,401,454
Ensembl chr12:6,383,609...6,399,550
JBrowse link
G GRIN2D glutamate ionotropic receptor NMDA type subunit 2D involved_in ISO PMID:19793963 ComplexPortal PMID:19793963 RGD:150521643 NCBI chr 6:53,809,590...53,849,535
Ensembl chr 6:53,806,174...53,848,789
JBrowse link
G GRIP2 glutamate receptor interacting protein 2 involved_in ISO PMID:20083202 UniProt PMID:20083202 RGD:4107359 NCBI chr13:69,949,608...70,088,719
Ensembl chr13:69,988,459...70,088,718
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:28975565 RGD:13506836 NCBI chr 2:5,209,435...5,227,543
Ensembl chr 2:5,209,439...5,227,758
JBrowse link
G GSK3B glycogen synthase kinase 3 beta ISO RGD PMID:20007479 RGD:4107027 NCBI chr13:140,136,109...140,370,197
Ensembl chr13:140,136,158...140,369,569
JBrowse link
G NETO1 neuropilin and tolloid like 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5139965|PMID:21734292) MGI
Ensembl
TreeGrafter
PMID:21734292 GO_REF:0000107 GO_REF:0000118 MGI:5139965 NCBI chr 1:150,711,486...150,821,626
Ensembl chr 1:150,711,628...150,817,437
JBrowse link
G NETO2 neuropilin and tolloid like 2 NOT|acts_upstream_of_or_within ISO (MGI:5139965|PMID:21734292) MGI PMID:21734292 MGI:5139965 NCBI chr 6:37,443,534...37,506,589
Ensembl chr 6:37,443,699...37,505,736
JBrowse link
G NGFR nerve growth factor receptor ISO RGD PMID:23114219 RGD:10414080 NCBI chr12:25,699,410...25,720,355
Ensembl chr12:25,699,427...25,720,356
JBrowse link
G NLGN1 neuroligin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:111,851,007...112,727,202
Ensembl chr13:112,035,854...112,725,618
JBrowse link
G NLGN3 neuroligin 3 involved_in ISO (MGI:5320268|PMID:21642956) CACAO PMID:21642956 MGI:5320268 NCBI chr  X:57,174,506...57,204,770
Ensembl chr  X:57,176,103...57,201,461
JBrowse link
G NRXN1 neurexin 1 involved_in ISO (MGI:5284755|PMID:19098102)
(MGI:4366191|PMID:19822762)
BHF-UCL PMID:19098102 PMID:19822762 MGI:4366191 MGI:5284755 NCBI chr 3:89,799,426...90,914,205
Ensembl chr 3:89,803,519...90,382,034
JBrowse link
G PRKAR1B protein kinase cAMP-dependent type I regulatory subunit beta ISO RGD PMID:33479380 RGD:150519900 NCBI chr 3:343,124...425,154
Ensembl chr 3:343,139...425,165
JBrowse link
G PRKCZ protein kinase C zeta involved_in ISO PMID:11914719 UniProt PMID:11914719 RGD:8554098 NCBI chr 6:64,073,343...64,159,187
Ensembl chr 6:64,068,577...64,163,472
JBrowse link
G PTEN phosphatase and tensin homolog involved_in ISO (MGI:3772418|PMID:18082964) CACAO PMID:18082964 MGI:3772418 NCBI chr14:99,929,590...100,021,619 JBrowse link
G PTK2B protein tyrosine kinase 2 beta involved_in ISO PMID:11239437 Alzheimers_University_of_Toronto PMID:11239437 RGD:8553497 NCBI chr14:11,063,662...11,194,196
Ensembl chr14:11,064,492...11,194,192
JBrowse link
G RELN reelin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:103,460,855...103,963,728
Ensembl chr 9:103,460,863...103,963,883
JBrowse link
G RGS4 regulator of G protein signaling 4 ISO RGD PMID:17220354 RGD:13524537 NCBI chr 4:87,383,336...87,390,478
Ensembl chr 4:87,383,345...87,390,893
JBrowse link
G RIMS1 regulating synaptic membrane exocytosis 1 involved_in ISO (MGI:4887275|PMID:21262469) ParkinsonsUK-UCL PMID:21262469 MGI:4887275 NCBI chr 1:51,785,140...52,246,456
Ensembl chr 1:51,785,495...52,244,934
JBrowse link
G RIMS2 regulating synaptic membrane exocytosis 2 involved_in ISO (MGI:4887275|PMID:21262469) ParkinsonsUK-UCL PMID:21262469 MGI:4887275 NCBI chr 4:32,999,615...33,613,413
Ensembl chr 4:32,999,618...33,614,366
JBrowse link
G SHANK1 SH3 and multiple ankyrin repeat domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:55,452,095...55,496,304
Ensembl chr 6:55,451,094...55,499,031
JBrowse link
G SHANK3 SH3 and multiple ankyrin repeat domains 3 involved_in ISO (MGI:4948759|PMID:21423165), (MGI:5285139|PMID:21167025), (MGI:5320264|PMID:21795692) BHF-UCL PMID:21167025 PMID:21423165 PMID:21795692 MGI:4948759 MGI:5285139 MGI:5320264 NCBI chr 5:41,376...93,033
Ensembl chr 5:41,786...93,177
JBrowse link
G SSH1 slingshot protein phosphatase 1 ISO RGD PMID:20442266 RGD:11535133 NCBI chr14:41,963,946...42,030,842
Ensembl chr14:41,968,466...42,025,726
JBrowse link
G STX1A syntaxin 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:10,974,127...10,991,846
Ensembl chr 3:10,974,127...10,991,873
JBrowse link
G TBC1D24 TBC1 domain family member 24 ISO RGD PMID:24469796 RGD:11537391 NCBI chr 3:39,545,688...39,572,320
Ensembl chr 3:39,545,218...39,571,277
JBrowse link
G WNT7A Wnt family member 7A involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:70,538,802...70,602,464
Ensembl chr13:70,538,894...70,602,454
JBrowse link
positive regulation of mini excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB2 adrenoceptor beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:150,032,649...150,035,591
Ensembl chr 2:150,033,579...150,040,731
JBrowse link
G AFDN afadin, adherens junction formation factor ISO RGD PMID:22948147 RGD:13838731 NCBI chr 1:1,569,652...1,698,475
Ensembl chr 1:1,570,272...1,698,694
JBrowse link
G IGSF11 immunoglobulin superfamily member 11 involved_in ISO PMID:26595655 UniProt PMID:26595655 RGD:11085699 NCBI chr13:141,148,489...141,289,504
Ensembl chr13:141,093,021...141,289,496
JBrowse link
regulation of acetylcholine-gated cation channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit ISO RGD PMID:11904236 RGD:704387 NCBI chr17:62,424,672...62,436,646
Ensembl chr17:62,423,878...62,435,728
JBrowse link
regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DMPK DM1 protein kinase acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3721737|PMID:11526199) MGI
Ensembl
PMID:11526199 GO_REF:0000107 MGI:3721737 NCBI chr 6:52,100,259...52,110,822
Ensembl chr 6:52,100,259...52,110,478
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17778
    regulation of biological process 12447
      regulation of signaling 3661
        regulation of signal transduction 3113
          modulation of excitatory postsynaptic potential 62
            negative regulation of excitatory postsynaptic potential + 14
            positive regulation of excitatory postsynaptic potential + 40
            regulation of acetylcholine-gated cation channel activity + 1
            regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction 1
            regulation of mini excitatory postsynaptic potential + 4
Path 2
Term Annotations click to browse term
  biological_process 17778
    biological regulation 12789
      regulation of biological process 12447
        signaling 7482
          cell-cell signaling 1414
            synaptic signaling 936
              trans-synaptic signaling 899
                anterograde trans-synaptic signaling 892
                  chemical synaptic transmission 892
                    chemical synaptic transmission, postsynaptic 136
                      excitatory postsynaptic potential 121
                        modulation of excitatory postsynaptic potential 62
                          negative regulation of excitatory postsynaptic potential + 14
                          positive regulation of excitatory postsynaptic potential + 40
                          regulation of acetylcholine-gated cation channel activity + 1
                          regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction 1
                          regulation of mini excitatory postsynaptic potential + 4
paths to the root