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ONTOLOGY REPORT - ANNOTATIONS

Term:modulation of excitatory postsynaptic potential
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Accession:GO:0098815 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.


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modulation of excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072 		JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 ISO RGD PMID:12597860 RGD:152995391 NCBI chr21:15,976,931...16,357,578
Ensembl chr21:29,364,269...29,743,379 		JBrowse link
G GRIK2 glutamate ionotropic receptor kainate type subunit 2 ISO RGD PMID:12597860 RGD:152995391 NCBI chr 6:98,720,430...99,903,582
Ensembl chr 6:103,334,707...103,783,092 		JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A ISO RGD PMID:34233182 RGD:401940191 NCBI chr16:8,682,169...9,105,581
Ensembl chr16:9,919,143...10,336,167 		JBrowse link
G LOC100977072 neuronal acetylcholine receptor subunit alpha-7 involved_in ISO (MGI:4889154|PMID:20974225) ARUK-UCL PMID:20974225 MGI:4889154 NCBI chr15:10,525,535...10,667,227
Ensembl chr15:29,565,885...29,705,194 		JBrowse link
G PCLO piccolo presynaptic cytomatrix protein ISO RGD PMID:31074746 RGD:41408338 NCBI chr 7:74,714,364...75,126,518 JBrowse link
G SH3GL1 SH3 domain containing GRB2 like 1, endophilin A2 ISO RGD PMID:22750032 RGD:13463484 NCBI chr19:3,383,267...3,423,165
Ensembl chr19:4,329,750...4,340,121 		JBrowse link
G SLC8A2 solute carrier family 8 member A2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:6282180|PMID:29274751) ARUK-UCL
Ensembl		 PMID:29274751 GO_REF:0000107 MGI:6282180 NCBI chr19:44,420,146...44,464,242
Ensembl chr19:53,077,857...53,113,830 		JBrowse link
G SLC8A3 solute carrier family 8 member A3 acts_upstream_of_or_within ISO (MGI:6282180|PMID:29274751) ARUK-UCL PMID:29274751 MGI:6282180 NCBI chr14:50,634,091...50,779,712 JBrowse link
G STX1A syntaxin 1A involved_in ISO PMID:18703708 ParkinsonsUK-UCL PMID:18703708 RGD:11535099 Ensembl chr 7:80,852,495...80,862,255 JBrowse link
G TMEM108 transmembrane protein 108 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:130,105,824...130,468,122
Ensembl chr 3:137,775,339...137,944,660 		JBrowse link
G ZMYND8 zinc finger MYND-type containing 8 ISO RGD PMID:24117785 RGD:8554267 NCBI chr20:43,540,819...43,701,322
Ensembl chr20:44,624,487...44,772,032 		JBrowse link
negative regulation of excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBLN1 cerebellin 1 precursor involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:29,538,723...29,542,625
Ensembl chr16:48,427,645...48,430,512 		JBrowse link
G CELF4 CUGBP Elav-like family member 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21745337) Ensembl
MGI		 PMID:21745337 GO_REF:0000107 NCBI chr18:30,495,149...30,818,358
Ensembl chr18:34,068,123...34,374,372 		JBrowse link
G LOC100988043 eukaryotic initiation factor 4A-III ISO RGD PMID:17632064 RGD:10044262 NCBI chr17:74,221,793...74,233,738 JBrowse link
G LOC100994646 neuroligin-4, Y-linked involved_in IEA Ensembl GO_REF:0000107 Ensembl chr  X:5,756,699...6,018,008 JBrowse link
G LRRK2 leucine rich repeat kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:48,343,621...48,488,337
Ensembl chr12:49,205,930...49,350,462 		JBrowse link
G MTMR2 myotubularin related protein 2 involved_in ISO PMID:20410104 BHF-UCL PMID:20410104 RGD:8553482 NCBI chr11:90,839,577...90,929,731
Ensembl chr11:94,367,038...94,457,138 		JBrowse link
G NLGN3 neuroligin 3 involved_in ISO (MGI:5286761|PMID:21808020) CACAO PMID:21808020 MGI:5286761 NCBI chr  X:60,413,098...60,439,359
Ensembl chr  X:70,469,764...70,496,526 		JBrowse link
G NLGN4X neuroligin 4 X-linked involved_in ISO (PMID:19726642) BHF-UCL PMID:19726642 Ensembl chr  X:5,756,699...6,018,008 JBrowse link
G NPY2R neuropeptide Y receptor Y2 ISO RGD PMID:12055128 RGD:1642608 NCBI chr 4:147,542,551...147,586,397
Ensembl chr 4:159,401,080...159,402,231 		JBrowse link
G PLK2 polo like kinase 2 ISO RGD PMID:20802490 RGD:152995511 NCBI chr 5:55,543,828...55,550,116
Ensembl chr 5:57,177,836...57,184,793 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase ISO RGD PMID:19033459 RGD:10413844 NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770 		JBrowse link
G PTEN phosphatase and tensin homolog involved_in ISO (MGI:5320272|PMID:21411674) CACAO PMID:21411674 MGI:5320272 NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605 		JBrowse link
G S1PR2 sphingosine-1-phosphate receptor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11553273) Ensembl
MGI		 PMID:11553273 GO_REF:0000107 NCBI chr19:9,771,888...9,781,944
Ensembl chr19:10,436,502...10,437,563 		JBrowse link
G TMEM25 transmembrane protein 25 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr11:113,368,595...113,384,290
Ensembl chr11:117,299,183...117,314,494 		JBrowse link
negative regulation of mini excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYNE1 spectrin repeat containing nuclear envelope protein 1 ISO RGD PMID:24191017 RGD:13209020 NCBI chr 6:149,936,306...150,454,822
Ensembl chr 6:154,627,904...155,144,076 		JBrowse link
positive regulation of excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein involved_in ISO (PMID:19118188) ARUK-UCL PMID:19118188 NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072 		JBrowse link
G BAIAP2 BAR/IMD domain containing adaptor protein 2 ISO RGD PMID:15758177 RGD:9684984 NCBI chr17:75,460,491...75,542,700
Ensembl chr17:81,187,021...81,269,714 		JBrowse link
G CACNB3 calcium voltage-gated channel auxiliary subunit beta 3 ISO RGD PMID:22187436 RGD:13514092 NCBI chr12:39,918,022...39,931,386
Ensembl chr12:40,797,293...40,811,409 		JBrowse link
G CUX2 cut like homeobox 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:108,600,286...108,975,588
Ensembl chr12:112,175,555...112,311,221 		JBrowse link
G DBN1 drebrin 1 ISO RGD PMID:19174472 RGD:10398809 NCBI chr 5:172,758,316...172,774,974
Ensembl chr 5:179,820,791...179,836,872 		JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 involved_in ISO PMID:12930820 CACAO PMID:12930820 RGD:8554754 NCBI chr17:7,219,911...7,247,509
Ensembl chr17:7,207,483...7,235,985 		JBrowse link
G DRD4 dopamine receptor D4 ISO RGD PMID:21622557 RGD:7248611 NCBI chr11:640,401...646,775 JBrowse link
G DVL1 dishevelled segment polarity protein 1 involved_in ISO PMID:21670302 ParkinsonsUK-UCL PMID:21670302 RGD:10449514 NCBI chr 1:92,469...106,748
Ensembl chr 1:1,292,052...1,301,008 		JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 ISO RGD PMID:23345231 RGD:405100730 NCBI chr 5:148,879,996...149,206,914
Ensembl chr 5:154,879,080...155,204,660 		JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 involved_in ISO PMID:12930820
PMID:22246434
PMID:19793963		 BHF-UCL
ComplexPortal		 PMID:12930820 PMID:19793963 PMID:22246434 RGD:150521639 RGD:150521643 RGD:8554754 NCBI chr 9:108,198,350...108,228,887
Ensembl chr 9:137,168,722...137,197,382 		JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A involved_in ISO PMID:12930820
PMID:22246434		 BHF-UCL
RGD
ComplexPortal		 PMID:12930820 PMID:22246434 PMID:29339324 RGD:150521639 RGD:401940161 RGD:8554754 NCBI chr16:8,682,169...9,105,581
Ensembl chr16:9,919,143...10,336,167 		JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B involved_in ISO PMID:19793963 ComplexPortal
RGD		 PMID:19793963 PMID:29339324 RGD:150521643 RGD:401940161 NCBI chr12:13,543,104...13,987,437
Ensembl chr12:13,969,387...14,388,799 		JBrowse link
G GRIN2C glutamate ionotropic receptor NMDA type subunit 2C involved_in ISO PMID:19793963 ComplexPortal PMID:19793963 RGD:150521643 NCBI chr17:68,787,670...68,807,192 JBrowse link
G GRIN2D glutamate ionotropic receptor NMDA type subunit 2D involved_in ISO PMID:19793963 ComplexPortal PMID:19793963 RGD:150521643 NCBI chr19:45,392,258...45,447,004 JBrowse link
G GRIP2 glutamate receptor interacting protein 2 involved_in ISO PMID:20083202 UniProt PMID:20083202 RGD:4107359 NCBI chr 3:14,411,825...14,525,388
Ensembl chr 3:14,756,638...14,804,952 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:28975565 RGD:13506836 NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta ISO RGD PMID:20007479 RGD:4107027 NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771 		JBrowse link
G LOC100977072 neuronal acetylcholine receptor subunit alpha-7 involved_in ISO (MGI:5825427|PMID:19118188) ARUK-UCL PMID:19118188 MGI:5825427 NCBI chr15:10,525,535...10,667,227
Ensembl chr15:29,565,885...29,705,194 		JBrowse link
G NETO1 neuropilin and tolloid like 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21734292) Ensembl
MGI
TreeGrafter		 PMID:21734292 GO_REF:0000107 GO_REF:0000118 NCBI chr18:66,114,425...66,240,141
Ensembl chr18:69,408,116...69,527,333 		JBrowse link
G NETO2 neuropilin and tolloid like 2 NOT|acts_upstream_of_or_within ISO (PMID:21734292) MGI PMID:21734292 NCBI chr16:27,343,333...27,405,173
Ensembl chr16:46,235,165...46,284,344 		JBrowse link
G NGFR nerve growth factor receptor ISO RGD PMID:23114219 RGD:10414080 NCBI chr17:8,089,600...8,109,361
Ensembl chr17:8,075,316...8,094,966 		JBrowse link
G NLGN1 neuroligin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:170,416,885...171,333,094
Ensembl chr 3:178,810,253...179,503,756 		JBrowse link
G NLGN2 neuroligin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:7,438,853...7,454,014 JBrowse link
G NLGN3 neuroligin 3 involved_in ISO (MGI:5320268|PMID:21642956) CACAO PMID:21642956 MGI:5320268 NCBI chr  X:60,413,098...60,439,359
Ensembl chr  X:70,469,764...70,496,526 		JBrowse link
G NRXN1 neurexin 1 involved_in ISO (MGI:5284755|PMID:19098102)
(MGI:4366191|PMID:19822762)		 BHF-UCL PMID:19098102 PMID:19822762 MGI:4366191 MGI:5284755 NCBI chr2A:50,063,398...51,178,659
Ensembl chr2A:50,985,067...52,091,277 		JBrowse link
G PRKAR1B protein kinase cAMP-dependent type I regulatory subunit beta ISO RGD PMID:33479380 RGD:150519900 NCBI chr 7:700,691...876,497
Ensembl chr 7:923,668...1,097,456 		JBrowse link
G PRKCZ protein kinase C zeta involved_in ISO PMID:11914719 UniProt PMID:11914719 RGD:8554098 NCBI chr 1:763,942...901,531
Ensembl chr 1:1,920,219...2,045,855 		JBrowse link
G PTEN phosphatase and tensin homolog involved_in ISO (MGI:3772418|PMID:18082964) CACAO PMID:18082964 MGI:3772418 NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605 		JBrowse link
G PTK2B protein tyrosine kinase 2 beta involved_in ISO PMID:11239437 Alzheimers_University_of_Toronto PMID:11239437 RGD:8553497 NCBI chr 8:26,580,855...26,729,378
Ensembl chr 8:23,869,825...23,932,474 		JBrowse link
G RELN reelin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:95,464,285...95,984,813
Ensembl chr 7:108,208,344...108,728,037 		JBrowse link
G RGS4 regulator of G protein signaling 4 ISO RGD PMID:17220354 RGD:13524537 NCBI chr 1:138,488,317...138,496,497
Ensembl chr 1:142,284,040...142,292,225 		JBrowse link
G RIMS1 regulating synaptic membrane exocytosis 1 involved_in ISO (MGI:4887275|PMID:21262469) ParkinsonsUK-UCL PMID:21262469 MGI:4887275 NCBI chr 6:69,714,807...70,231,260
Ensembl chr 6:73,008,176...73,523,422 		JBrowse link
G RIMS2 regulating synaptic membrane exocytosis 2 involved_in ISO (MGI:4887275|PMID:21262469) ParkinsonsUK-UCL PMID:21262469 MGI:4887275 NCBI chr 8:100,156,403...100,894,128 JBrowse link
G SHANK1 SH3 and multiple ankyrin repeat domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:47,623,474...47,684,476
Ensembl chr19:56,526,577...56,580,442 		JBrowse link
G SHANK3 SH3 and multiple ankyrin repeat domains 3 involved_in ISO (MGI:4948759|PMID:21423165), (MGI:5285139|PMID:21167025), (MGI:5320264|PMID:21795692) BHF-UCL PMID:21167025 PMID:21423165 PMID:21795692 MGI:4948759 MGI:5285139 MGI:5320264 NCBI chr22:30,951,866...30,973,608 JBrowse link
G SSH1 slingshot protein phosphatase 1 ISO RGD PMID:20442266 RGD:11535133 NCBI chr12:106,357,147...106,432,295
Ensembl chr12:109,758,399...109,823,444 		JBrowse link
G STX1A syntaxin 1A involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 7:80,852,495...80,862,255 JBrowse link
G STX1B syntaxin 1B involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:23,956,426...23,979,646
Ensembl chr16:31,356,907...31,378,870 		JBrowse link
G TBC1D24 TBC1 domain family member 24 ISO RGD PMID:24469796 RGD:11537391 NCBI chr16:1,331,630...1,362,320
Ensembl chr16:2,581,835...2,603,912 		JBrowse link
G WNT7A Wnt family member 7A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:13,733,487...13,797,189
Ensembl chr 3:14,077,839...14,138,386 		JBrowse link
positive regulation of mini excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB2 adrenoceptor beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:144,259,756...144,398,421
Ensembl chr 5:150,267,554...150,315,892 		JBrowse link
G AFDN afadin, adherens junction formation factor ISO RGD PMID:22948147 RGD:13838731 NCBI chr 6:165,778,026...165,923,685
Ensembl chr 6:170,775,904...170,882,784 		JBrowse link
G IGSF11 immunoglobulin superfamily member 11 involved_in ISO PMID:26595655 UniProt PMID:26595655 RGD:11085699 NCBI chr 3:116,033,187...116,153,134
Ensembl chr 3:122,948,246...122,972,742 		JBrowse link
regulation of acetylcholine-gated cation channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit ISO RGD PMID:11904236 RGD:704387 NCBI chr20:59,730,759...59,748,678
Ensembl chr20:61,270,631...61,283,005 		JBrowse link
regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DMPK DM1 protein kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11526199) Ensembl
MGI		 PMID:11526199 GO_REF:0000107 NCBI chr19:42,779,173...42,791,981
Ensembl chr19:51,316,099...51,329,355 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16440
    regulation of biological process 11104
      regulation of signaling 3522
        regulation of signal transduction 3007
          modulation of excitatory postsynaptic potential 66
            negative regulation of excitatory postsynaptic potential + 15
            positive regulation of excitatory postsynaptic potential + 43
            regulation of acetylcholine-gated cation channel activity + 1
            regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction 1
            regulation of mini excitatory postsynaptic potential + 4
Path 2
Term Annotations click to browse term
  biological_process 16440
    biological regulation 11453
      regulation of biological process 11104
        signaling 5935
          cell-cell signaling 1334
            synaptic signaling 867
              trans-synaptic signaling 832
                anterograde trans-synaptic signaling 824
                  chemical synaptic transmission 824
                    chemical synaptic transmission, postsynaptic 143
                      excitatory postsynaptic potential 127
                        modulation of excitatory postsynaptic potential 66
                          negative regulation of excitatory postsynaptic potential + 15
                          positive regulation of excitatory postsynaptic potential + 43
                          regulation of acetylcholine-gated cation channel activity + 1
                          regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction 1
                          regulation of mini excitatory postsynaptic potential + 4
paths to the root