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ONTOLOGY REPORT - ANNOTATIONS


Term:modulation of excitatory postsynaptic potential
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Accession:GO:0098815 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.



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modulation of excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in ISO UniProtKB:P49582 (PMID:20974225) RGD PMID:20974225 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO UniProtKB:P05067 (MGI:4889154|PMID:20974225) RGD PMID:20974225 MGI:4889154 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Pclo piccolo (presynaptic cytomatrix protein) IMP RGD PMID:31074746 RGD:41408338 NCBI chr 4:19,691,439...20,050,015
Ensembl chr 4:19,695,315...20,049,885
JBrowse link
G Sh3gl1 SH3 domain containing GRB2 like 1, endophilin A2 IMP RGD PMID:22750032 RGD:13463484 NCBI chr 9:842,285...869,753
Ensembl chr 9:842,288...869,716
JBrowse link
G Slc8a2 solute carrier family 8 member A2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:6282180|PMID:29274751)
Ensembl
RGD
PMID:29274751 GO_REF:0000107 MGI:6282180 NCBI chr 1:76,816,583...76,852,928
Ensembl chr 1:76,808,725...76,847,072
JBrowse link
G Slc8a3 solute carrier family 8 member A3 acts_upstream_of_or_within ISO (MGI:6282180|PMID:29274751) RGD PMID:29274751 MGI:6282180 NCBI chr 6:100,874,359...101,007,989
Ensembl chr 6:100,874,369...101,007,508
JBrowse link
G Stx1a syntaxin 1A involved_in IMP PMID:18703708 ParkinsonsUK-UCL PMID:18703708 RGD:11535099 NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930
JBrowse link
G Tmem108 transmembrane protein 108 involved_in ISO (MGI:5825380|PMID:28096412) RGD PMID:28096412 MGI:5825380 NCBI chr 8:104,066,081...104,360,172
Ensembl chr 8:104,066,078...104,360,094
JBrowse link
G Zmynd8 zinc finger, MYND-type containing 8 IMP RGD PMID:24117785 RGD:8554267 NCBI chr 3:154,528,917...154,629,532
Ensembl chr 3:154,529,043...154,628,463
JBrowse link
negative regulation of excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbln1 cerebellin 1 precursor involved_in ISO (PMID:27418511) RGD PMID:27418511 NCBI chr19:19,608,763...19,612,572
Ensembl chr19:19,608,716...19,612,572
JBrowse link
G Celf4 CUGBP, Elav-like family member 4 acts_upstream_of_or_within ISO MGI:5425630 (MGI:5313512|PMID:21745337) RGD PMID:21745337 MGI:5313512 NCBI chr18:16,786,578...17,065,045
Ensembl chr18:16,786,867...17,064,786
JBrowse link
G Eif4a3 eukaryotic translation initiation factor 4A3 IMP RGD PMID:17632064 RGD:10044262 NCBI chr10:104,549,038...104,559,032
Ensembl chr10:104,549,038...104,559,057
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO (MGI:4941068|PMID:21307259) RGD PMID:21307259 MGI:4941068 NCBI chr 7:122,826,712...122,987,711
Ensembl chr 7:122,826,696...122,987,703
JBrowse link
G Mtmr2 myotubularin related protein 2 involved_in IMP PMID:20410104 BHF-UCL PMID:20410104 RGD:8553482 NCBI chr 8:10,617,993...10,670,724
Ensembl chr 8:10,617,993...10,668,172
JBrowse link
G Nlgn3 neuroligin 3 involved_in ISO (MGI:5286761|PMID:21808020) RGD PMID:21808020 MGI:5286761 NCBI chr  X:66,427,926...66,457,378
Ensembl chr  X:66,429,458...66,451,876
JBrowse link
G Npy2r neuropeptide Y receptor Y2 IDA RGD PMID:12055128 RGD:1642608 NCBI chr 2:167,901,999...167,912,165
Ensembl chr 2:167,903,879...167,905,024
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase IMP RGD PMID:19033459 RGD:10413844 NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Pten phosphatase and tensin homolog involved_in ISO (MGI:5320272|PMID:21411674) RGD PMID:21411674 MGI:5320272 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 acts_upstream_of_or_within ISO MGI:2180817 (MGI:2157237|PMID:11553273) RGD PMID:11553273 MGI:2157237 NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574
JBrowse link
G Tmem25 transmembrane protein 25 involved_in IBA
ISO
PMID:21873635
(MGI:6370252|PMID:31424425)
RGD PMID:31424425 PMID:21873635 MGI:6370252, RGD:13792537 NCBI chr 8:45,107,116...45,112,657
Ensembl chr 8:45,107,121...45,116,389
JBrowse link
negative regulation of mini excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syne1 spectrin repeat containing nuclear envelope protein 1 IMP RGD PMID:24191017 RGD:13209020 NCBI chr 1:41,512,146...41,983,382
Ensembl chr 1:41,512,030...41,983,322
JBrowse link
positive regulation of excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in ISO ComplexPortal:CPX-1134|UniProtKB:P49582 (PMID:19118188) RGD PMID:19118188 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Baiap2 BAR/IMD domain containing adaptor protein 2 IMP RGD PMID:15758177 RGD:9684984 NCBI chr10:105,223,065...105,290,130
Ensembl chr10:105,223,090...105,290,134
JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 IMP RGD PMID:22187436 RGD:13514092 NCBI chr 7:129,784,799...129,797,074
Ensembl chr 7:129,783,674...129,797,074
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA
ISO
GO_REF:0000107
ComplexPortal:CPX-1134|UniProtKB:P05067:PRO_0000000092 (MGI:5825427|PMID:19118188)
Ensembl
RGD
PMID:19118188 GO_REF:0000107 MGI:5825427 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Cux2 cut-like homeobox 2 involved_in ISO (MGI:4836115|PMID:20510857) RGD PMID:20510857 MGI:4836115 NCBI chr12:34,507,723...34,707,581
Ensembl chr12:34,520,959...34,705,806
JBrowse link
G Dbn1 drebrin 1 IMP RGD PMID:19174472 RGD:10398809 NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 involved_in IDA
IMP
PMID:12930820 BHF-UCL
CACAO
PMID:12930820 PMID:12930820 RGD:8554754, RGD:8554754 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
JBrowse link
G Drd4 dopamine receptor D4 IMP RGD PMID:21622557 RGD:7248611 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
G Dvl1 dishevelled segment polarity protein 1 involved_in IGI PMID:21670302 ParkinsonsUK-UCL PMID:21670302 RGD:10449514 NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 involved_in IDA PMID:12930820
PMID:19793963
PMID:22246434
BHF-UCL
ComplexPortal
PMID:12930820 PMID:19793963 PMID:22246434 RGD:8554754, RGD:150521643, RGD:150521639 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A involved_in IDA PMID:12930820 BHF-UCL PMID:12930820 RGD:8554754 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B involved_in IDA PMID:19793963 ComplexPortal PMID:19793963 RGD:150521643 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Grip2 glutamate receptor interacting protein 2 involved_in IMP PMID:20083202 UniProt PMID:20083202 RGD:4107359 NCBI chr 4:124,271,456...124,356,538
Ensembl chr 4:124,271,456...124,321,268
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IMP RGD PMID:28975565 RGD:13506836 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IMP RGD PMID:20007479 RGD:4107027 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Neto1 neuropilin and tolloid like 1 acts_upstream_of_or_within ISO MGI:3836584 (MGI:5139965|PMID:21734292) RGD PMID:21734292 MGI:5139965 NCBI chr18:79,635,633...79,753,913
Ensembl chr18:79,635,633...79,749,030
JBrowse link
G Neto2 neuropilin and tolloid like 2 NOT|acts_upstream_of_or_within ISO MGI:5141222 (MGI:5139965|PMID:21734292) RGD PMID:21734292 MGI:5139965 NCBI chr19:21,344,299...21,418,182
Ensembl chr19:21,344,289...21,417,023
JBrowse link
G Ngfr nerve growth factor receptor IMP RGD PMID:23114219 RGD:10414080 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nlgn1 neuroligin 1 involved_in IDA
ISO
IMP
PMID:17582332
(MGI:3803801|PMID:17582332), (MGI:5493186|PMID:23143522)
PMID:19628693
UniProtKB:Q99K10 (PMID:23143522)
PMID:19730411
RGD PMID:17582332 PMID:23143522 PMID:17582332 PMID:19628693 PMID:19730411 MGI:3803801 MGI:5493186, RGD:8553502, RGD:8554760, RGD:8554379 NCBI chr 2:108,256,236...109,181,530
Ensembl chr 2:108,257,824...109,002,464
JBrowse link
G Nlgn2 neuroligin 2 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:5284797|PMID:15620359)
GO_REF:0000107
BHF-UCL
RGD
Ensembl
PMID:15620359 GO_REF:0000024 GO_REF:0000107 MGI:5284797 NCBI chr10:54,544,588...54,557,854
Ensembl chr10:54,544,588...54,558,434
JBrowse link
G Nlgn3 neuroligin 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:5320268|PMID:21642956)
BHF-UCL
RGD
PMID:21642956 GO_REF:0000024 MGI:5320268 NCBI chr  X:66,427,926...66,457,378
Ensembl chr  X:66,429,458...66,451,876
JBrowse link
G Nrxn1 neurexin 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:4366191|PMID:19822762), (MGI:5284755|PMID:19098102)
BHF-UCL
RGD
PMID:19098102 PMID:19822762 GO_REF:0000024 MGI:4366191 MGI:5284755 NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710
JBrowse link
G Prkar1b protein kinase cAMP-dependent type I regulatory subunit beta IMP RGD PMID:33479380 RGD:150519900 NCBI chr12:15,492,233...15,624,942
Ensembl chr12:15,511,801...15,624,942
JBrowse link
G Prkcz protein kinase C, zeta involved_in IDA PMID:11914719 UniProt PMID:11914719 RGD:8554098 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Pten phosphatase and tensin homolog involved_in ISO (MGI:3772418|PMID:18082964) RGD PMID:18082964 MGI:3772418 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in IMP PMID:11239437 Alzheimers_University_of_Toronto PMID:11239437 RGD:8553497 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
JBrowse link
G Reln reelin involved_in IEA
ISO
GO_REF:0000107
(MGI:3765383|PMID:17229826), (MGI:4442532|PMID:20357114), (MGI:5619457|PMID:21814183)
Ensembl
RGD
PMID:17229826 PMID:20357114 PMID:21814183 GO_REF:0000107 MGI:3765383 MGI:4442532 MGI:5619457 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
JBrowse link
G Rgs4 regulator of G-protein signaling 4 IMP RGD PMID:17220354 RGD:13524537 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 involved_in ISS
ISO
GO_REF:0000024
UniProtKB:Q99NE5|UniProtKB:Q9EQZ7 (MGI:4887275|PMID:21262469)
ParkinsonsUK-UCL
RGD
PMID:21262469 GO_REF:0000024 MGI:4887275 NCBI chr 9:24,696,959...25,196,368
Ensembl chr 9:24,698,854...25,196,631
JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 involved_in ISS
ISO
GO_REF:0000024
UniProtKB:Q99NE5|UniProtKB:Q9EQZ7 (MGI:4887275|PMID:21262469)
ParkinsonsUK-UCL
RGD
PMID:21262469 GO_REF:0000024 MGI:4887275 NCBI chr 7:70,248,104...70,759,134
Ensembl chr 7:70,243,872...70,757,491
JBrowse link
G Shank1 SH3 and multiple ankyrin repeat domains 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3775591|PMID:18272690)
BHF-UCL
RGD
PMID:18272690 GO_REF:0000024 MGI:3775591 NCBI chr 1:94,807,879...94,857,356
Ensembl chr 1:94,808,276...94,855,824
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 involved_in ISS
ISO
IEA
PMID:21795692
(MGI:4948759|PMID:21423165), (MGI:5285139|PMID:21167025), (MGI:5320264|PMID:21795692)
GO_REF:0000024
GO_REF:0000107
RGD
BHF-UCL
Ensembl
PMID:21167025 PMID:21423165 PMID:21795692 PMID:21795692 GO_REF:0000024 GO_REF:0000107 MGI:4948759 MGI:5285139 MGI:5320264, RGD:7349315 NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374
JBrowse link
G Ssh1 slingshot protein phosphatase 1 IMP RGD PMID:20442266 RGD:11535133 NCBI chr12:42,621,127...42,683,262
Ensembl chr12:42,621,135...42,683,274
JBrowse link
G Stx1a syntaxin 1A involved_in ISO UniProtKB:O35526|UniProtKB:P61264 (MGI:5521403|PMID:24133272) RGD PMID:24133272 MGI:5521403 NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930
JBrowse link
G Stx1b syntaxin 1B involved_in ISS
ISO
GO_REF:0000024
UniProtKB:O35526 (MGI:5521403|PMID:24133272)
ParkinsonsUK-UCL
RGD
PMID:24133272 GO_REF:0000024 MGI:5521403 NCBI chr 1:182,415,544...182,434,385
Ensembl chr 1:182,415,546...182,441,280
JBrowse link
G Tbc1d24 TBC1 domain family, member 24 IMP RGD PMID:24469796 RGD:11537391 NCBI chr10:13,205,819...13,236,013
Ensembl chr10:13,209,895...13,236,050
JBrowse link
G Wnt7a Wnt family member 7A involved_in ISO (PMID:21670302)
UniProtKB:Q9WVB9 (MGI:5014434|PMID:21670302)
RGD PMID:21670302 MGI:5014434 NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981
JBrowse link
positive regulation of mini excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 involved_in IEA
ISO
GO_REF:0000107
ComplexPortal:CPX-1070 (MGI:5902682|PMID:20395454)
Ensembl
RGD
PMID:20395454 GO_REF:0000107 MGI:5902682 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Afdn afadin, adherens junction formation factor IMP RGD PMID:22948147 RGD:13838731 NCBI chr 1:53,884,711...54,034,216
Ensembl chr 1:53,905,373...54,034,216
JBrowse link
G Igsf11 immunoglobulin superfamily, member 11 involved_in IMP PMID:26595655 UniProt PMID:26595655 RGD:11085699 NCBI chr11:61,733,139...61,884,059
Ensembl chr11:61,733,144...61,868,348
JBrowse link
regulation of acetylcholine-gated cation channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in ISO ComplexPortal:CPX-1134|UniProtKB:P49582 (PMID:19118188) RGD PMID:19118188 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit IMP RGD PMID:11904236 RGD:704387 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin acts_upstream_of_or_within ISO (MGI:5468741|PMID:23173741) RGD PMID:23173741 MGI:5468741 NCBI chr 1:205,731,814...205,743,430
Ensembl chr 1:205,733,872...205,743,421
JBrowse link
G Dmpk DM1 protein kinase acts_upstream_of_or_within ISO MGI:2182402 (MGI:3721737|PMID:11526199) RGD PMID:11526199 MGI:3721737 NCBI chr 1:78,730,255...78,740,585
Ensembl chr 1:78,730,275...78,740,593
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    cellular process 18359
      signal transduction 6908
        regulation of signal transduction 2999
          modulation of excitatory postsynaptic potential 59
            negative regulation of excitatory postsynaptic potential + 12
            positive regulation of excitatory postsynaptic potential + 40
            regulation of acetylcholine-gated cation channel activity + 2
            regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction 2
            regulation of mini excitatory postsynaptic potential + 4
Path 2
Term Annotations click to browse term
  biological_process 19497
    cellular process 18359
      cell communication 7576
        cell-cell signaling 1746
          synaptic signaling 927
            trans-synaptic signaling 900
              anterograde trans-synaptic signaling 891
                chemical synaptic transmission 891
                  chemical synaptic transmission, postsynaptic 128
                    excitatory postsynaptic potential 119
                      modulation of excitatory postsynaptic potential 59
                        negative regulation of excitatory postsynaptic potential + 12
                        positive regulation of excitatory postsynaptic potential + 40
                        regulation of acetylcholine-gated cation channel activity + 2
                        regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction 2
                        regulation of mini excitatory postsynaptic potential + 4
paths to the root