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ONTOLOGY REPORT - ANNOTATIONS


Term:modulation of excitatory postsynaptic potential
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Accession:GO:0098815 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.


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modulation of excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO UniProtKB:P49582 (PMID:20974225) RGD PMID:20974225 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ISO UniProtKB:P05067 (MGI:MGI:4889154|PMID:20974225) RGD PMID:20974225 MGI:MGI:4889154 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Sh3gl1 SH3 domain containing GRB2 like 1, endophilin A2 IMP RGD PMID:22750032 RGD:13463484 NCBI chr 9:11,031,847...11,055,285
Ensembl chr 9:11,031,841...11,055,285
JBrowse link
G Slc8a2 solute carrier family 8 member A2 IEA
ISO
GO_REF:0000107
(MGI:MGI:6282180|PMID:29274751)
Ensembl
RGD
PMID:29274751 GO_REF:0000107, MGI:MGI:6282180 NCBI chr 1:78,029,555...78,054,042
Ensembl chr 1:78,025,995...78,060,111
JBrowse link
G Slc8a3 solute carrier family 8 member A3 ISO (MGI:MGI:6282180|PMID:29274751) RGD PMID:29274751 MGI:MGI:6282180 NCBI chr 6:104,889,500...105,099,408
Ensembl chr 6:104,891,376...105,097,054
JBrowse link
G Stx1a syntaxin 1A IMP PMID:18703708 ParkinsonsUK-UCL PMID:18703708 RGD:11535099 NCBI chr12:24,682,050...24,710,002
Ensembl chr12:24,682,041...24,710,019
JBrowse link
G Tmem108 transmembrane protein 108 ISO (MGI:MGI:5825380|PMID:28096412) RGD PMID:28096412 MGI:MGI:5825380 NCBI chr 8:111,968,568...112,265,623
Ensembl chr 8:111,970,288...111,984,572
JBrowse link
G Zmynd8 zinc finger, MYND-type containing 8 IMP RGD PMID:24117785 RGD:8554267 NCBI chr 3:162,480,766...162,594,145
Ensembl chr 3:162,480,804...162,581,610
JBrowse link
negative regulation of excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbln1 cerebellin 1 precursor ISO (PMID:27418511) RGD PMID:27418511 NCBI chr19:20,607,507...20,611,316
Ensembl chr19:20,607,507...20,611,316
JBrowse link
G Celf4 CUGBP, Elav-like family member 4 ISO MGI:MGI:5425630 (MGI:MGI:5313512|PMID:21745337) RGD PMID:21745337 MGI:MGI:5313512 NCBI chr18:17,689,090...18,079,835
Ensembl chr18:17,698,038...17,716,880
JBrowse link
G Eif4a3 eukaryotic translation initiation factor 4A3 IMP RGD PMID:17632064 RGD:10044262 NCBI chr10:108,415,201...108,425,195
Ensembl chr10:108,415,202...108,425,206
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 ISO (MGI:MGI:4941068|PMID:21307259) RGD PMID:21307259 MGI:MGI:4941068 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584
JBrowse link
G Mtmr2 myotubularin related protein 2 IMP PMID:20410104 BHF-UCL PMID:20410104 RGD:8553482 NCBI chr 8:12,283,471...12,334,014
Ensembl chr 8:12,284,528...12,333,316
JBrowse link
G Nlgn3 neuroligin 3 ISO
IEA
(MGI:MGI:5286761|PMID:21808020)
GO_REF:0000107
RGD
Ensembl
PMID:21808020 GO_REF:0000107, MGI:MGI:5286761 NCBI chr  X:71,199,390...71,227,460
Ensembl chr  X:71,199,491...71,222,732
JBrowse link
G Npy2r neuropeptide Y receptor Y2 IDA RGD PMID:12055128 RGD:1642608 NCBI chr 2:181,528,949...181,538,145
Ensembl chr 2:181,530,832...181,531,978
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase IMP RGD PMID:19033459 RGD:10413844 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Pten phosphatase and tensin homolog ISO (MGI:MGI:5320272|PMID:21411674) RGD PMID:21411674 MGI:MGI:5320272 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 ISO MGI:MGI:2180817 (MGI:MGI:2157237|PMID:11553273) RGD PMID:11553273 MGI:MGI:2157237 NCBI chr 8:21,984,914...21,995,806
Ensembl chr 8:21,984,914...21,995,806
JBrowse link
G Tmem25 transmembrane protein 25 ISO
IBA
(MGI:MGI:6370252|PMID:31424425)
PMID:21873635
RGD PMID:31424425, PMID:21873635 MGI:MGI:6370252, RGD:13792537 NCBI chr 8:49,100,759...49,106,258
Ensembl chr 8:49,100,759...49,106,177
JBrowse link
negative regulation of mini excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syne1 spectrin repeat containing nuclear envelope protein 1 IMP RGD PMID:24191017 RGD:13209020 NCBI chr 1:41,608,287...41,763,591
NCBI chr 1:41,844,840...42,086,662
Ensembl chr 1:41,608,418...42,077,535
JBrowse link
positive regulation of excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO ComplexPortal:CPX-1134|UniProtKB:P49582 (PMID:19118188) RGD PMID:19118188 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Baiap2 BAR/IMD domain containing adaptor protein 2 IMP RGD PMID:15758177 RGD:9684984 NCBI chr10:109,107,326...109,187,458
Ensembl chr10:109,107,389...109,187,115
JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 IMP RGD PMID:22187436 RGD:13514092 NCBI chr 7:140,311,120...140,324,902
Ensembl chr 7:140,315,368...140,324,902
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit IEA
ISO
GO_REF:0000107
ComplexPortal:CPX-1134|UniProtKB:P05067:PRO_0000000092 (MGI:MGI:5825427|PMID:19118188)
Ensembl
RGD
PMID:19118188 GO_REF:0000107, MGI:MGI:5825427 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Cux2 cut-like homeobox 2 ISO (MGI:MGI:4836115|PMID:20510857) RGD PMID:20510857 MGI:MGI:4836115 NCBI chr12:40,016,774...40,221,067
Ensembl chr12:40,018,937...40,219,291
JBrowse link
G Dbn1 drebrin 1 IMP RGD PMID:19174472 RGD:10398809 NCBI chr17:9,679,511...9,693,878
Ensembl chr17:9,679,628...9,693,820
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 IDA
IMP
PMID:12930820 BHF-UCL
CACAO
PMID:12930820, PMID:12930820 RGD:8554754, RGD:8554754 NCBI chr10:56,625,845...56,655,543
Ensembl chr10:56,627,411...56,653,599
JBrowse link
G Drd4 dopamine receptor D4 IMP RGD PMID:21622557 RGD:7248611 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Dvl1 dishevelled segment polarity protein 1 IGI PMID:21670302 ParkinsonsUK-UCL PMID:21670302 RGD:10449514 NCBI chr 5:173,295,948...173,308,014
Ensembl chr 5:173,296,270...173,307,945
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 IDA PMID:12930820 BHF-UCL PMID:12930820 RGD:8554754 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A IDA PMID:12930820 BHF-UCL PMID:12930820 RGD:8554754 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Grip2 glutamate receptor interacting protein 2 IMP PMID:20083202 UniProt PMID:20083202 RGD:4107359 NCBI chr 4:123,585,184...123,636,040
Ensembl chr 4:123,586,231...123,636,040
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IMP RGD PMID:28975565 RGD:13506836 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IMP RGD PMID:20007479 RGD:4107027 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G LOC103690160 SH3 and multiple ankyrin repeat domains protein 2-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:215,208,591...215,246,638
Ensembl chr 1:215,214,853...215,241,723
JBrowse link
G Neto1 neuropilin and tolloid like 1 ISO MGI:MGI:3836584 (MGI:MGI:5139965|PMID:21734292) RGD PMID:21734292 MGI:MGI:5139965 NCBI chr18:83,471,342...83,585,043
Ensembl chr18:83,471,342...83,584,357
JBrowse link
G Neto2 neuropilin and tolloid like 2 NOT ISO MGI:MGI:5141222 (MGI:MGI:5139965|PMID:21734292) RGD PMID:21734292 MGI:MGI:5139965 NCBI chr19:22,450,579...22,486,530
Ensembl chr19:22,450,030...22,486,531
JBrowse link
G Ngfr nerve growth factor receptor IMP RGD PMID:23114219 RGD:10414080 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Nlgn1 neuroligin 1 IDA
ISO
IMP
PMID:17582332
(MGI:MGI:3803801|PMID:17582332), (MGI:MGI:5493186|PMID:23143522)
UniProtKB:Q99K10 (PMID:23143522)
PMID:19730411
PMID:19628693
RGD PMID:17582332, PMID:23143522, PMID:17582332, PMID:19730411, PMID:19628693 MGI:MGI:3803801, MGI:MGI:5493186, RGD:8553502, RGD:8554379, RGD:8554760 NCBI chr 2:111,057,291...111,973,681
Ensembl chr 2:111,057,291...111,793,326
JBrowse link
G Nlgn2 neuroligin 2 ISO
ISS
IEA
(MGI:MGI:5284797|PMID:15620359)
GO_REF:0000024
GO_REF:0000107
RGD
BHF-UCL
Ensembl
PMID:15620359 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5284797 NCBI chr10:56,431,586...56,444,847
Ensembl chr10:56,431,573...56,444,847
JBrowse link
G Nlgn3 neuroligin 3 ISO
ISS
IEA
(MGI:MGI:5320268|PMID:21642956)
GO_REF:0000024
GO_REF:0000107
RGD
BHF-UCL
Ensembl
PMID:21642956 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5320268 NCBI chr  X:71,199,390...71,227,460
Ensembl chr  X:71,199,491...71,222,732
JBrowse link
G Nrxn1 neurexin 1 ISS
ISO
GO_REF:0000024
(MGI:MGI:4366191|PMID:19822762), (MGI:MGI:5284755|PMID:19098102)
BHF-UCL
RGD
PMID:19098102, PMID:19822762 GO_REF:0000024, MGI:MGI:4366191, MGI:MGI:5284755 NCBI chr 6:13,886,757...15,191,660
Ensembl chr 6:13,886,740...15,191,660
JBrowse link
G Prkcz protein kinase C, zeta IDA PMID:11914719 UniProt PMID:11914719 RGD:8554098 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Pten phosphatase and tensin homolog ISO (MGI:MGI:3772418|PMID:18082964) RGD PMID:18082964 MGI:MGI:3772418 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IMP PMID:11239437 Alzheimers_University_of_Toronto PMID:11239437 RGD:8553497 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Reln reelin IEA
ISO
GO_REF:0000107
(MGI:MGI:3765383|PMID:17229826), (MGI:MGI:4442532|PMID:20357114), (MGI:MGI:5619457|PMID:21814183)
Ensembl
RGD
PMID:17229826, PMID:20357114, PMID:21814183 GO_REF:0000107, MGI:MGI:3765383, MGI:MGI:4442532, MGI:MGI:5619457 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
JBrowse link
G Rgs4 regulator of G-protein signaling 4 IMP RGD PMID:17220354 RGD:13524537 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 ISO
ISS
UniProtKB:Q99NE5|UniProtKB:Q9EQZ7 (MGI:MGI:4887275|PMID:21262469)
GO_REF:0000024
RGD
ParkinsonsUK-UCL
PMID:21262469 GO_REF:0000024, MGI:MGI:4887275 NCBI chr 9:28,440,408...28,973,246
Ensembl chr 9:28,442,229...28,973,246
JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 ISO
ISS
UniProtKB:Q99NE5|UniProtKB:Q9EQZ7 (MGI:MGI:4887275|PMID:21262469)
GO_REF:0000024
RGD
ParkinsonsUK-UCL
PMID:21262469 GO_REF:0000024, MGI:MGI:4887275 NCBI chr 7:78,091,998...78,594,164
Ensembl chr 7:78,092,037...78,594,138
JBrowse link
G Shank1 SH3 and multiple ankyrin repeat domains 1 ISO
IBA
ISS
(MGI:MGI:3775591|PMID:18272690)
PMID:21873635
GO_REF:0000024
RGD
BHF-UCL
PMID:18272690, PMID:21873635 GO_REF:0000024, MGI:MGI:3775591, RGD:13792537 NCBI chr 1:100,297,137...100,344,377
Ensembl chr 1:100,297,152...100,344,377
JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:217,149,156...217,593,950
Ensembl chr 1:217,151,166...217,592,763
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 ISS
IEA
IBA
ISO
GO_REF:0000024
GO_REF:0000107
PMID:21873635
(MGI:MGI:4948759|PMID:21423165), (MGI:MGI:5285139|PMID:21167025), (MGI:MGI:5320264|PMID:21795692)
BHF-UCL
Ensembl
RGD
PMID:21167025, PMID:21423165, PMID:21795692, PMID:21873635, PMID:21795692 GO_REF:0000024, GO_REF:0000107, MGI:MGI:4948759, MGI:MGI:5285139, MGI:MGI:5320264, RGD:13792537, RGD:7349315 NCBI chr 7:130,474,278...130,534,679
Ensembl chr 7:130,474,279...130,534,679
JBrowse link
G Ssh1 slingshot protein phosphatase 1 IMP RGD PMID:20442266 RGD:11535133 NCBI chr12:48,403,184...48,447,964
Ensembl chr12:48,403,797...48,446,977
JBrowse link
G Stx1a syntaxin 1A ISO UniProtKB:O35526|UniProtKB:P61264 (MGI:MGI:5521403|PMID:24133272) RGD PMID:24133272 MGI:MGI:5521403 NCBI chr12:24,682,050...24,710,002
Ensembl chr12:24,682,041...24,710,019
JBrowse link
G Stx1b syntaxin 1B ISO
ISS
UniProtKB:O35526 (MGI:MGI:5521403|PMID:24133272)
GO_REF:0000024
RGD
ParkinsonsUK-UCL
PMID:24133272 GO_REF:0000024, MGI:MGI:5521403 NCBI chr 1:199,251,842...199,270,465
Ensembl chr 1:199,251,844...199,270,627
JBrowse link
G Tbc1d24 TBC1 domain family, member 24 IMP RGD PMID:24469796 RGD:11537391 NCBI chr10:13,551,100...13,576,739
Ensembl chr10:13,551,100...13,558,384
JBrowse link
G Wnt7a Wnt family member 7A ISO (PMID:21670302)
UniProtKB:Q9WVB9 (MGI:MGI:5014434|PMID:21670302)
RGD PMID:21670302 MGI:MGI:5014434 NCBI chr 4:122,994,425...123,040,609
Ensembl chr 4:122,994,425...123,040,609
JBrowse link
positive regulation of mini excitatory postsynaptic potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 IEA
ISO
GO_REF:0000107
ComplexPortal:CPX-1070 (MGI:MGI:5902682|PMID:20395454)
Ensembl
RGD
PMID:20395454 GO_REF:0000107, MGI:MGI:5902682 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Afdn afadin, adherens junction formation factor IMP RGD PMID:22948147 RGD:13838731 NCBI chr 1:53,713,873...53,861,918
Ensembl chr 1:53,715,693...53,802,658
JBrowse link
G Igsf11 immunoglobulin superfamily, member 11 IMP PMID:26595655 UniProt PMID:26595655 RGD:11085699 NCBI chr11:64,286,691...64,421,248
Ensembl chr11:64,286,694...64,421,248
JBrowse link
regulation of acetylcholine-gated cation channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO ComplexPortal:CPX-1134|UniProtKB:P49582 (PMID:19118188) RGD PMID:19118188 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit IMP RGD PMID:11904236 RGD:704387 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin ISO (MGI:MGI:5468741|PMID:23173741) RGD PMID:23173741 MGI:MGI:5468741 NCBI chr 1:225,035,956...225,046,137
Ensembl chr 1:225,037,737...225,046,040
JBrowse link
G Dmpk DM1 protein kinase ISO MGI:MGI:2182402 (MGI:MGI:3721737|PMID:11526199) RGD PMID:11526199 MGI:MGI:3721737 NCBI chr 1:79,988,096...79,999,358
Ensembl chr 1:79,989,019...79,999,364
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    cellular process 18798
      signal transduction 7011
        regulation of signal transduction 2934
          modulation of excitatory postsynaptic potential 58
            negative regulation of excitatory postsynaptic potential + 12
            positive regulation of excitatory postsynaptic potential + 40
            regulation of acetylcholine-gated cation channel activity + 2
            regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction 2
            regulation of mini excitatory postsynaptic potential + 4
Path 2
Term Annotations click to browse term
  biological_process 20027
    cellular process 18798
      cell communication 7664
        cell-cell signaling 1738
          synaptic signaling 917
            trans-synaptic signaling 889
              anterograde trans-synaptic signaling 880
                chemical synaptic transmission 880
                  chemical synaptic transmission, postsynaptic 127
                    excitatory postsynaptic potential 118
                      modulation of excitatory postsynaptic potential 58
                        negative regulation of excitatory postsynaptic potential + 12
                        positive regulation of excitatory postsynaptic potential + 40
                        regulation of acetylcholine-gated cation channel activity + 2
                        regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction 2
                        regulation of mini excitatory postsynaptic potential + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.