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ONTOLOGY REPORT - ANNOTATIONS


Term:spontaneous synaptic transmission
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Accession:GO:0098814 term browser browse the term
Definition:The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential.
Comment:This is typically measured via detection of mini excitatory post-synaptic currents (mEPSCs).
Synonyms:exact_synonym: basal synaptic transmission


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spontaneous synaptic transmission term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbln2 cerebellin 2 precursor ISS
ISO
GO_REF:0000024
(MGI:MGI:6220615|PMID:30287486)
UniProt
RGD
PMID:30287486 GO_REF:0000024, MGI:MGI:6220615 NCBI chr18:83,775,568...83,783,841
Ensembl chr18:83,777,665...83,782,930
JBrowse link
G Nsg1 neuronal vesicle trafficking associated 1 IMP PMID:15911354 UniProt PMID:15911354 RGD:9850096 NCBI chr14:77,380,264...77,402,007
Ensembl chr14:77,380,262...77,401,996
JBrowse link
negative regulation of spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A IMP RGD PMID:16899074 RGD:10002752 NCBI chr 4:29,976,485...30,247,371
Ensembl chr 4:29,978,739...30,241,911
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO (PMID:22314364) RGD PMID:22314364 NCBI chr 1:48,880,015...50,069,998 JBrowse link
positive regulation of spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stx1b syntaxin 1B ISO (MGI:MGI:5603022|PMID:24587181) RGD PMID:24587181 MGI:MGI:5603022 NCBI chr 1:199,251,842...199,270,465
Ensembl chr 1:199,251,844...199,270,627
JBrowse link
regulation of spontaneous synaptic transmission term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor ISO
IEA
UniProtKB:P05067 (PMID:15457210)
GO_REF:0000107
RGD
Ensembl
PMID:15457210 GO_REF:0000107 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G App amyloid beta precursor protein ISO UniProtKB:Q15109 (PMID:15457210) RGD PMID:15457210 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Itgb1 integrin subunit beta 1 IEA
ISO
GO_REF:0000107
(MGI:MGI:5629870|PMID:25716834)
Ensembl
RGD
PMID:25716834 GO_REF:0000107, MGI:MGI:5629870 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Slc12a2 solute carrier family 12 member 2 IMP
ISO
PMID:16227993
UniProtKB:P09055 (MGI:MGI:3608187|PMID:16227993), (MGI:MGI:5629870|PMID:25716834)
RGD PMID:16227993, PMID:25716834, PMID:16227993 MGI:MGI:3608187, MGI:MGI:5629870, RGD:1580584 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
JBrowse link
spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Doc2a double C2 domain alpha ISO MGI:MGI:102788|MGI:MGI:1100497|MGI:MGI:1926250 (MGI:MGI:5141208|PMID:21521611) RGD PMID:21521611 MGI:MGI:5141208 NCBI chr 1:198,282,828...198,288,611
Ensembl chr 1:198,284,473...198,288,113
JBrowse link
G Doc2b double C2 domain beta IEA
ISO
GO_REF:0000107
MGI:MGI:102788|MGI:MGI:109446|MGI:MGI:1926250 (MGI:MGI:5141208|PMID:21521611)
Ensembl
RGD
PMID:21521611 GO_REF:0000107, MGI:MGI:5141208 NCBI chr10:63,921,255...63,952,944
Ensembl chr10:63,928,064...63,952,726
JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 ISO UniProtKB:Q99NE5|UniProtKB:Q9EQZ7 (MGI:MGI:4887275|PMID:21262469) RGD PMID:21262469 MGI:MGI:4887275 NCBI chr 9:28,440,408...28,973,246
Ensembl chr 9:28,442,229...28,973,246
JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 ISO
ISS
UniProtKB:Q99NE5|UniProtKB:Q9EQZ7 (MGI:MGI:4887275|PMID:21262469)
GO_REF:0000024
RGD
ParkinsonsUK-UCL
PMID:21262469 GO_REF:0000024, MGI:MGI:4887275 NCBI chr 7:78,091,998...78,594,164
Ensembl chr 7:78,092,037...78,594,138
JBrowse link
G Rph3a rabphilin 3A IEA
ISO
GO_REF:0000107
MGI:MGI:109446|MGI:MGI:1100497|MGI:MGI:1926250 (MGI:MGI:5141208|PMID:21521611)
Ensembl
RGD
PMID:21521611 GO_REF:0000107, MGI:MGI:5141208 NCBI chr12:41,073,296...41,149,799
Ensembl chr12:41,073,824...41,148,490
JBrowse link
G Stx1b syntaxin 1B ISO UniProtKB:O35526 (MGI:MGI:3803800|PMID:18703708), (MGI:MGI:5521403|PMID:24133272) RGD PMID:18703708, PMID:24133272 MGI:MGI:3803800, MGI:MGI:5521403 NCBI chr 1:199,251,842...199,270,465
Ensembl chr 1:199,251,844...199,270,627
JBrowse link
G Syt1 synaptotagmin 1 ISO MGI:MGI:1857252 (MGI:MGI:5141208|PMID:21521611) RGD PMID:21521611 MGI:MGI:5141208 NCBI chr 7:50,084,063...50,638,996
Ensembl chr 7:50,084,060...50,638,798
JBrowse link
G Unc13b unc-13 homolog B IGI PMID:21262469 ParkinsonsUK-UCL PMID:21262469 RGD:10047275 NCBI chr 5:58,505,449...58,714,396
Ensembl chr 5:58,505,500...58,715,576
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    signaling 7588
      cell-cell signaling 1752
        synaptic signaling 896
          trans-synaptic signaling 870
            anterograde trans-synaptic signaling 863
              chemical synaptic transmission 863
                spontaneous synaptic transmission 16
                  regulation of spontaneous synaptic transmission + 7
                  spontaneous neurotransmitter secretion + 10
Path 2
Term Annotations click to browse term
  biological_process 20014
    cellular process 18788
      cell communication 7669
        cell-cell signaling 1752
          synaptic signaling 896
            trans-synaptic signaling 870
              anterograde trans-synaptic signaling 863
                chemical synaptic transmission 863
                  spontaneous synaptic transmission 16
                    regulation of spontaneous synaptic transmission + 7
                    spontaneous neurotransmitter secretion + 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.