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ONTOLOGY REPORT - ANNOTATIONS


Term:spontaneous synaptic transmission
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Accession:GO:0098814 term browser browse the term
Definition:The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential.
Comment:This is typically measured via detection of mini excitatory post-synaptic currents (mEPSCs).
Synonyms:exact_synonym: basal synaptic transmission


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spontaneous synaptic transmission term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbln2 cerebellin 2 precursor protein IMP (MGI:MGI:6220615|PMID:30287486) UniProt PMID:30287486 MGI:MGI:6220615 NCBI chr18:86,711,061...86,718,283
Ensembl chr18:86,711,110...86,718,283
JBrowse link
G Nsg1 neuron specific gene family member 1 ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr 5:38,137,193...38,159,743
Ensembl chr 5:38,137,192...38,159,907
JBrowse link
negative regulation of spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr 6:4,902,872...5,165,661
Ensembl chr 6:4,902,917...5,165,661
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr17:10,840,359...12,063,370
Ensembl chr17:10,840,384...12,063,361
JBrowse link
positive regulation of spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stx1b syntaxin 1B IMP (MGI:MGI:5603022|PMID:24587181) ParkinsonsUK-UCL PMID:24587181 MGI:MGI:5603022 NCBI chr 7:127,803,900...127,824,531
Ensembl chr 7:127,803,900...127,824,549
JBrowse link
regulation of spontaneous synaptic transmission term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr17:34,597,460...34,600,937
Ensembl chr17:34,597,862...34,600,936
JBrowse link
G App amyloid beta (A4) precursor protein ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) IMP (MGI:MGI:5629870|PMID:25716834) ARUK-UCL PMID:25716834 MGI:MGI:5629870 NCBI chr 8:128,685,654...128,733,579
Ensembl chr 8:128,685,654...128,733,200
JBrowse link
G Slc12a2 solute carrier family 12, member 2 IMP
ISO
IGI
(MGI:MGI:3608187|PMID:16227993)
(MGI:MGI:5629870|PMID:25716834)
ARUK-UCL
MGI
PMID:16227993, PMID:25716834 GO_REF:0000096, MGI:MGI:3608187, MGI:MGI:4417868, MGI:MGI:5629870 NCBI chr18:57,878,512...57,946,821
Ensembl chr18:57,878,678...57,946,821
JBrowse link
spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Doc2a double C2, alpha IDA
IGI
(MGI:MGI:5141208|PMID:21521611) MGI PMID:21521611 MGI:MGI:5141208 NCBI chr 7:126,846,983...126,852,705
Ensembl chr 7:126,847,416...126,852,705
JBrowse link
G Doc2b double C2, beta IDA
IGI
(MGI:MGI:5141208|PMID:21521611) MGI PMID:21521611 MGI:MGI:5141208 NCBI chr11:75,768,270...75,796,060
Ensembl chr11:75,768,966...75,796,049
JBrowse link
G Doc2g double C2, gamma IGI (MGI:MGI:5141208|PMID:21521611) MGI PMID:21521611 MGI:MGI:5141208 NCBI chr19:4,003,385...4,007,005
Ensembl chr19:4,003,313...4,007,005
JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 IGI (MGI:MGI:4887275|PMID:21262469) ParkinsonsUK-UCL PMID:21262469 MGI:MGI:4887275 NCBI chr 1:22,285,972...22,806,158
Ensembl chr 1:22,286,251...22,805,994
JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 IGI (MGI:MGI:4887275|PMID:21262469) ParkinsonsUK-UCL PMID:21262469 MGI:MGI:4887275 NCBI chr15:39,198,286...39,684,372
Ensembl chr15:39,198,261...39,684,372
JBrowse link
G Rph3a rabphilin 3A IGI (MGI:MGI:5141208|PMID:21521611) MGI PMID:21521611 MGI:MGI:5141208 NCBI chr 5:120,940,499...121,010,116
Ensembl chr 5:120,940,499...121,010,092
JBrowse link
G Stx1b syntaxin 1B IGI
IMP
(MGI:MGI:5521403|PMID:24133272)
(MGI:MGI:3803800|PMID:18703708)
ParkinsonsUK-UCL PMID:18703708, PMID:24133272 MGI:MGI:3803800, MGI:MGI:5521403 NCBI chr 7:127,803,900...127,824,531
Ensembl chr 7:127,803,900...127,824,549
JBrowse link
G Syt1 synaptotagmin I IMP (MGI:MGI:5141208|PMID:21521611) MGI PMID:21521611 MGI:MGI:5141208 NCBI chr10:108,497,650...109,010,980
Ensembl chr10:108,497,650...109,010,982
JBrowse link
G Unc13b unc-13 homolog B ISO RGD GO_REF:0000096, MGI:MGI:4417868 NCBI chr 4:43,046,193...43,264,873
Ensembl chr 4:43,058,953...43,264,871
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23392
    signaling 6933
      cell-cell signaling 1748
        synaptic signaling 935
          trans-synaptic signaling 903
            anterograde trans-synaptic signaling 894
              chemical synaptic transmission 894
                spontaneous synaptic transmission 17
                  regulation of spontaneous synaptic transmission + 7
                  spontaneous neurotransmitter secretion + 11
Path 2
Term Annotations click to browse term
  biological_process 23392
    cellular process 17416
      cell communication 7014
        cell-cell signaling 1748
          synaptic signaling 935
            trans-synaptic signaling 903
              anterograde trans-synaptic signaling 894
                chemical synaptic transmission 894
                  spontaneous synaptic transmission 17
                    regulation of spontaneous synaptic transmission + 7
                    spontaneous neurotransmitter secretion + 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.