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ONTOLOGY REPORT - ANNOTATIONS


Term:spontaneous synaptic transmission
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Accession:GO:0098814 term browser browse the term
Definition:The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential.
Comment:This is typically measured via detection of mini excitatory post-synaptic currents (mEPSCs).
Synonyms:exact_synonym: basal synaptic transmission


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spontaneous synaptic transmission term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBLN2 cerebellin 2 precursor ISS UniProt GO_REF:0000024 NCBI chr18:72,533,720...72,638,485
Ensembl chr18:72,536,680...72,638,521
JBrowse link
G NSG1 neuronal vesicle trafficking associated 1 ISS UniProtKB GO_REF:0000024 NCBI chr 4:4,386,532...4,419,058
Ensembl chr 4:4,348,140...4,419,058
JBrowse link
negative regulation of spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPP1R9A protein phosphatase 1 regulatory subunit 9A IEA Ensembl GO_REF:0000107 NCBI chr 7:94,907,202...95,296,415
Ensembl chr 7:94,907,202...95,296,415
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase IMP (PMID:22314364) ParkinsonsUK-UCL PMID:22314364 NCBI chr 6:161,347,417...162,727,802
Ensembl chr 6:161,347,417...162,727,771
Ensembl chr 6:161,347,417...162,727,771
JBrowse link
positive regulation of spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G STX1B syntaxin 1B IEA Ensembl GO_REF:0000107 NCBI chr16:30,989,256...31,010,638
Ensembl chr16:30,989,256...31,010,638
JBrowse link
regulation of spontaneous synaptic transmission term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor IGI (PMID:15457210) ARUK-UCL PMID:15457210 NCBI chr 6:32,180,969...32,184,380
Ensembl chr 6:32,180,968...32,184,322
JBrowse link
G APP amyloid beta precursor protein IGI (PMID:15457210) ARUK-UCL PMID:15457210 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G ITGB1 integrin subunit beta 1 ISS ARUK-UCL GO_REF:0000024 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,900,318...33,005,792
JBrowse link
G SLC12A2 solute carrier family 12 member 2 ISS (PMID:16227993) ARUK-UCL PMID:16227993 GO_REF:0000024 NCBI chr 5:128,083,766...128,189,677
Ensembl chr 5:128,083,766...128,189,677
JBrowse link
spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DOC2A double C2 domain alpha IEA Ensembl GO_REF:0000107 NCBI chr16:30,005,514...30,023,280
Ensembl chr16:30,005,514...30,023,270
JBrowse link
G DOC2B double C2 domain beta IEA Ensembl GO_REF:0000107 NCBI chr17:142,789...181,650
Ensembl chr17:142,789...181,650
JBrowse link
G DOC2GP double C2 domain gamma, pseudogene ISO (MGI:MGI:5141208|PMID:21521611) MGI PMID:21521611 MGI:MGI:5141208 NCBI chr11:67,613,524...67,615,664
Ensembl chr11:67,612,651...67,616,257
JBrowse link
G RIMS1 regulating synaptic membrane exocytosis 1 ISO (MGI:MGI:4887275|PMID:21262469) ParkinsonsUK-UCL PMID:21262469 MGI:MGI:4887275 NCBI chr 6:71,886,703...72,403,145
Ensembl chr 6:71,886,703...72,403,143
JBrowse link
G RIMS2 regulating synaptic membrane exocytosis 2 ISS ParkinsonsUK-UCL GO_REF:0000024 NCBI chr 8:103,499,934...104,256,094
Ensembl chr 8:103,500,696...104,256,094
JBrowse link
G RPH3A rabphilin 3A IEA Ensembl GO_REF:0000107 NCBI chr12:112,575,236...112,898,881
Ensembl chr12:112,570,380...112,898,881
JBrowse link
G STX1B syntaxin 1B IEA Ensembl GO_REF:0000107 NCBI chr16:30,989,256...31,010,638
Ensembl chr16:30,989,256...31,010,638
JBrowse link
G SYT1 synaptotagmin 1 IEA Ensembl GO_REF:0000107 NCBI chr12:78,863,982...79,452,008
Ensembl chr12:78,863,993...79,452,008
JBrowse link
G UNC13B unc-13 homolog B ISO PMID:21262469 ParkinsonsUK-UCL PMID:21262469 RGD:10047275 NCBI chr 9:35,162,009...35,405,338
Ensembl chr 9:35,161,992...35,405,338
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18670
    signaling 7207
      cell-cell signaling 2063
        synaptic signaling 995
          trans-synaptic signaling 967
            anterograde trans-synaptic signaling 958
              chemical synaptic transmission 958
                spontaneous synaptic transmission 17
                  regulation of spontaneous synaptic transmission + 7
                  spontaneous neurotransmitter secretion + 11
Path 2
Term Annotations click to browse term
  biological_process 18670
    cellular process 17687
      cell communication 7246
        cell-cell signaling 2063
          synaptic signaling 995
            trans-synaptic signaling 967
              anterograde trans-synaptic signaling 958
                chemical synaptic transmission 958
                  spontaneous synaptic transmission 17
                    regulation of spontaneous synaptic transmission + 7
                    spontaneous neurotransmitter secretion + 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.