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ONTOLOGY REPORT - ANNOTATIONS


Term:spontaneous synaptic transmission
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Accession:GO:0098814 term browser browse the term
Definition:The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential.
Comment:This is typically measured via detection of mini excitatory post-synaptic currents (mEPSCs).
Synonyms:exact_synonym: basal synaptic transmission


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spontaneous synaptic transmission term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBLN2 cerebellin 2 precursor ISO (MGI:MGI:6220615|PMID:30287486) UniProt PMID:30287486 MGI:MGI:6220615 NCBI chr18:65,906,154...66,010,195 JBrowse link
G NSG1 neuronal vesicle trafficking associated 1 ISO PMID:15911354 UniProt PMID:15911354 RGD:9850096 Ensembl chr 4:4,467,234...4,496,088 JBrowse link
negative regulation of spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPP1R9A protein phosphatase 1 regulatory subunit 9A ISO RGD PMID:16899074 RGD:10002752 NCBI chr 7:86,863,919...87,251,634
Ensembl chr 7:100,455,357...100,833,220
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase ISO (PMID:22314364) ParkinsonsUK-UCL PMID:22314364 NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770
JBrowse link
positive regulation of spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G STX1B syntaxin 1B ISO (MGI:MGI:5603022|PMID:24587181) ParkinsonsUK-UCL PMID:24587181 MGI:MGI:5603022 NCBI chr16:23,956,426...23,979,646
Ensembl chr16:31,356,907...31,378,870
JBrowse link
regulation of spontaneous synaptic transmission term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor ISO (PMID:15457210) ARUK-UCL PMID:15457210 NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641
JBrowse link
G APP amyloid beta precursor protein ISO (PMID:15457210) ARUK-UCL PMID:15457210 NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072
JBrowse link
G ITGB1 integrin subunit beta 1 ISO (MGI:MGI:5629870|PMID:25716834) ARUK-UCL PMID:25716834 MGI:MGI:5629870 NCBI chr10:33,023,573...33,081,384
Ensembl chr10:33,608,978...33,644,031
JBrowse link
G SLC12A2 solute carrier family 12 member 2 ISO PMID:16227993
(MGI:MGI:5629870|PMID:25716834)
(MGI:MGI:3608187|PMID:16227993)
ARUK-UCL PMID:16227993, PMID:25716834 MGI:MGI:3608187, MGI:MGI:5629870, RGD:1580584 NCBI chr 5:123,499,267...123,603,777
Ensembl chr 5:129,262,134...129,364,563
JBrowse link
spontaneous neurotransmitter secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DOC2A double C2 domain alpha ISO (MGI:MGI:5141208|PMID:21521611) MGI PMID:21521611 MGI:MGI:5141208 Ensembl chr16:30,378,922...30,384,142 JBrowse link
G DOC2B double C2 domain beta ISO (MGI:MGI:5141208|PMID:21521611) MGI PMID:21521611 MGI:MGI:5141208 NCBI chr17:19,854...58,336 JBrowse link
G RIMS1 regulating synaptic membrane exocytosis 1 ISO (MGI:MGI:4887275|PMID:21262469) ParkinsonsUK-UCL PMID:21262469 MGI:MGI:4887275 NCBI chr 6:69,714,807...70,231,260
Ensembl chr 6:73,008,176...73,523,422
JBrowse link
G RIMS2 regulating synaptic membrane exocytosis 2 ISO (MGI:MGI:4887275|PMID:21262469) ParkinsonsUK-UCL PMID:21262469 MGI:MGI:4887275 NCBI chr 8:100,156,403...100,894,128 JBrowse link
G RPH3A rabphilin 3A ISO (MGI:MGI:5141208|PMID:21521611) MGI PMID:21521611 MGI:MGI:5141208 NCBI chr12:110,393,495...110,504,099
Ensembl chr12:113,815,437...113,886,701
JBrowse link
G STX1B syntaxin 1B ISO (MGI:MGI:3803800|PMID:18703708)
(MGI:MGI:5521403|PMID:24133272)
ParkinsonsUK-UCL PMID:18703708, PMID:24133272 MGI:MGI:3803800, MGI:MGI:5521403 NCBI chr16:23,956,426...23,979,646
Ensembl chr16:31,356,907...31,378,870
JBrowse link
G SYT1 synaptotagmin 1 ISO (MGI:MGI:5141208|PMID:21521611) MGI PMID:21521611 MGI:MGI:5141208 NCBI chr12:76,392,955...76,981,800
Ensembl chr12:79,595,704...79,829,923
JBrowse link
G UNC13B unc-13 homolog B ISO PMID:21262469 ParkinsonsUK-UCL PMID:21262469 RGD:10047275 NCBI chr 9:35,011,350...35,255,148 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12564
    signaling 4292
      cell-cell signaling 1381
        synaptic signaling 662
          trans-synaptic signaling 641
            anterograde trans-synaptic signaling 633
              chemical synaptic transmission 633
                spontaneous synaptic transmission 16
                  regulation of spontaneous synaptic transmission + 7
                  spontaneous neurotransmitter secretion + 10
Path 2
Term Annotations click to browse term
  biological_process 12564
    cellular process 11665
      cell communication 4366
        cell-cell signaling 1381
          synaptic signaling 662
            trans-synaptic signaling 641
              anterograde trans-synaptic signaling 633
                chemical synaptic transmission 633
                  spontaneous synaptic transmission 16
                    regulation of spontaneous synaptic transmission + 7
                    spontaneous neurotransmitter secretion + 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.