ONTOLOGY REPORT - ANNOTATIONS
Term: xenophagy
Accession: GO:0098792
browse the term
Definition: The selective autophagy process in which a region of cytoplasm containing an intracellular pathogen or some part of an intracellular pathogen (e.g. viral capsid) is enclosed in a double membrane bound autophagosome, which then fuses with the lysosome leading to degradation of the contents.
Comment: While making xenophagy a subclass of (macro)autophagy may seem to directly contradict the definition of autophagy (literally self eating), it is clear that the same pathway is involved as in macroautophagy that doesn't target foreign material: formation of double-membrane-bounded autophagosomes that enclose a region of cytoplasm for degradation.
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AABR07025818.1
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
Ensembl chr16:48,598,506...48,599,444
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Atg16l1
autophagy related 16-like 1
acts_upstream_of_or_within
ISO
PR:Q80W47 (MGI:5605433|PMID:24954904)
RGD
PMID:24954904
MGI:5605433
NCBI chr 9:88,420,737...88,457,530
Ensembl chr 9:88,422,038...88,457,529
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Calcoco2
calcium binding and coiled-coil domain 2
involved_in
ISO
(PMID:25771791) (PMID:23022382), (PMID:25771791)
RGD
PMID:23022382 PMID:25771791
NCBI chr10:81,055,467...81,069,298
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Lgals8
galectin 8
involved_in
ISO ISS
(PMID:22246324), (PMID:28077878) GO_REF:0000024
RGD GO_Central
PMID:22246324 PMID:28077878
GO_REF:0000024
NCBI chr17:58,024,652...58,052,764
Ensembl chr17:58,028,105...58,052,764
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Mapk3
mitogen activated protein kinase 3
acts_upstream_of
ISO
MGI:1346858 (MGI:5299952|PMID:22033934)
RGD
PMID:22033934
MGI:5299952
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Nod1
nucleotide-binding oligomerization domain containing 1
acts_upstream_of
ISO
MGI:2674231 (MGI:5299952|PMID:22033934)
RGD
PMID:22033934
MGI:5299952
NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
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Nod2
nucleotide-binding oligomerization domain containing 2
acts_upstream_of
ISO
MGI:3529594 (MGI:5299952|PMID:22033934)
RGD
PMID:22033934
MGI:5299952
NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
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Ripk2
receptor-interacting serine-threonine kinase 2
acts_upstream_of
ISO
MGI:2660793 (MGI:5299952|PMID:22033934)
RGD
PMID:22033934
MGI:5299952
NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
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Rnf213
ring finger protein 213
involved_in
ISO
(PMID:34012115)
RGD
PMID:34012115
NCBI chr10:104,656,329...104,755,669
Ensembl chr10:104,656,883...104,757,918
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Tlr2
toll-like receptor 2
acts_upstream_of
ISO
MGI:2674036 (MGI:5299952|PMID:22033934)
RGD
PMID:22033934
MGI:5299952
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Wipi2
WD repeat domain, phosphoinositide interacting 2
acts_upstream_of_or_within
ISO
PR:Q8C0J2 (MGI:5605433|PMID:24954904)
RGD
PMID:24954904
MGI:5605433
NCBI chr12:11,911,369...11,939,799
Ensembl chr12:11,911,337...11,939,794
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Lrsam1
leucine rich repeat and sterile alpha motif containing 1
involved_in
ISO
(PMID:23245322)
RGD
PMID:23245322
NCBI chr 3:16,223,367...16,264,261
Ensembl chr 3:16,223,367...16,264,154
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Mapk3
mitogen activated protein kinase 3
acts_upstream_of_or_within
ISO
MGI:1346858 (MGI:5299952|PMID:22033934)
RGD
PMID:22033934
MGI:5299952
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Nod1
nucleotide-binding oligomerization domain containing 1
acts_upstream_of_or_within
ISO
MGI:2674231 (MGI:5299952|PMID:22033934)
RGD
PMID:22033934
MGI:5299952
NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
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Nod2
nucleotide-binding oligomerization domain containing 2
acts_upstream_of_or_within
ISO
MGI:3529594 (MGI:5299952|PMID:22033934)
RGD
PMID:22033934
MGI:5299952
NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
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Optn
optineurin
involved_in
ISO IEA
(PMID:21617041) GO_REF:0000107
RGD Ensembl
PMID:21617041
GO_REF:0000107
NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251
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Ripk2
receptor-interacting serine-threonine kinase 2
acts_upstream_of_or_within
ISO
MGI:2660793 (MGI:5299952|PMID:22033934)
RGD
PMID:22033934
MGI:5299952
NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
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Rnf31
ring finger protein 31
involved_in
ISO
(PMID:28481331)
RGD
PMID:28481331
NCBI chr15:29,083,047...29,095,328
Ensembl chr15:29,083,631...29,101,915
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Tbk1
TANK-binding kinase 1
involved_in
ISO
(MGI:5645201|PMID:21617041)
RGD
PMID:21617041
MGI:5645201
NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
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Tlr2
toll-like receptor 2
acts_upstream_of_or_within
ISO
MGI:2674036 (MGI:5299952|PMID:22033934)
RGD
PMID:22033934
MGI:5299952
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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