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ONTOLOGY REPORT - ANNOTATIONS
Term:xenophagy
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Accession:GO:0098792 term browser browse the term
Definition:The selective autophagy process in which a region of cytoplasm containing an intracellular pathogen or some part of an intracellular pathogen (e.g. viral capsid) is enclosed in a double membrane bound autophagosome, which then fuses with the lysosome leading to degradation of the contents.
Comment:While making xenophagy a subclass of (macro)autophagy may seem to directly contradict the definition of autophagy (literally self eating), it is clear that the same pathway is involved as in macroautophagy that doesn't target foreign material: formation of double-membrane-bounded autophagosomes that enclose a region of cytoplasm for degradation.

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xenophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atg16l1 autophagy related 16-like 1 JBrowse link 9 94,879,876 94,915,231 RGD:1624291
G Calcoco2 calcium binding and coiled-coil domain 2 JBrowse link 10 83,935,087 83,963,750 RGD:1624291
G Lgals8 galectin 8 JBrowse link 17 66,487,451 66,515,316 RGD:1600115
RGD:1624291
G Wipi2 WD repeat domain, phosphoinositide interacting 2 JBrowse link 12 13,969,704 13,998,134 RGD:1624291
positive regulation of xenophagy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrsam1 leucine rich repeat and sterile alpha motif containing 1 JBrowse link 3 11,970,401 12,009,463 RGD:1624291
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:1624291
G Nod1 nucleotide-binding oligomerization domain containing 1 JBrowse link 4 85,123,965 85,175,206 RGD:1624291
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:1624291
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:1624291
RGD:1600115
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:1624291
G Tbk1 TANK-binding kinase 1 JBrowse link 7 63,655,247 63,687,978 RGD:1624291
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1624291
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    interspecies interaction between organisms 1887
      response to other organism 1678
        defense response to other organism 1089
          xenophagy 12
            negative regulation of xenophagy 0
            positive regulation of xenophagy 8
            regulation of xenophagy + 8
Path 2
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12097
      catabolic process 2515
        cellular catabolic process 2148
          autophagy 459
            macroautophagy 222
              selective autophagy 63
                xenophagy 12
                  negative regulation of xenophagy 0
                  positive regulation of xenophagy 8
                  regulation of xenophagy + 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.