xenophagy - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS	{{ watchLinkText }}

Term:	xenophagy	go back to main search page
Accession:	GO:0098792	browse the term
Definition:	The selective autophagy process in which a region of cytoplasm containing an intracellular pathogen or some part of an intracellular pathogen (e.g. viral capsid) is enclosed in a double membrane bound autophagosome, which then fuses with the lysosome leading to degradation of the contents.
Comment:	While making xenophagy a subclass of (macro)autophagy may seem to directly contradict the definition of autophagy (literally self eating), it is clear that the same pathway is involved as in macroautophagy that doesn't target foreign material: formation of double-membrane-bounded autophagosomes that enclose a region of cytoplasm for degradation.

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Rat (13) Mouse (12) Human (12) Chinchilla (12) Bonobo (12) Dog (12) Squirrel (12) Pig (12) All
Genes (13)

xenophagy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

involved_in

PMID:21873635

GO_Central

Ensembl chr16:51,786,459...51,787,151

G

autophagy related 16-like 1

acts_upstream_of_or_within

PR:Q80W47 (MGI:5605433|PMID:24954904)

NCBI chr 9:94,879,876...94,915,231
Ensembl chr 9:94,879,745...94,915,228

G

calcium binding and coiled-coil domain 2

involved_in

(PMID:25771791)

NCBI chr10:83,935,087...83,963,750

G

galectin 8

involved_in

(PMID:22246324), (PMID:28077878)
GO_REF:0000107
GO_REF:0000024

RGD
Ensembl
GO_Central

PMID:22246324 PMID:28077878

GO_REF:0000024 GO_REF:0000107

NCBI chr17:66,487,451...66,515,316
Ensembl chr17:66,487,457...66,511,870

G

WD repeat domain, phosphoinositide interacting 2

acts_upstream_of_or_within

PR:Q8C0J2 (MGI:5605433|PMID:24954904)

NCBI chr12:13,969,704...13,998,134
Ensembl chr12:13,969,586...13,998,172

positive regulation of xenophagy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

leucine rich repeat and sterile alpha motif containing 1

involved_in

(PMID:23245322)

NCBI chr 3:11,970,401...12,009,463
Ensembl chr 3:11,972,813...12,007,570

G

mitogen activated protein kinase 3

acts_upstream_of_or_within

MGI:1346858 (MGI:5299952|PMID:22033934)

NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975

G

nucleotide-binding oligomerization domain containing 1

acts_upstream_of_or_within

MGI:2674231 (MGI:5299952|PMID:22033934)

NCBI chr 4:85,123,965...85,175,206
Ensembl chr 4:85,123,960...85,174,951

G

nucleotide-binding oligomerization domain containing 2

acts_upstream_of_or_within

MGI:3529594 (MGI:5299952|PMID:22033934)

NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492

G

optineurin

involved_in

(PMID:21617041)
GO_REF:0000107

GO_REF:0000107

NCBI chr17:77,167,700...77,218,374
Ensembl chr17:77,167,740...77,218,389

G

receptor-interacting serine-threonine kinase 2

acts_upstream_of_or_within

MGI:2660793 (MGI:5299952|PMID:22033934)

NCBI chr 5:29,838,713...29,870,390
Ensembl chr 5:29,838,747...29,870,735

G

TANK-binding kinase 1

involved_in

(MGI:5645201|PMID:21617041)

NCBI chr 7:63,655,247...63,687,978
Ensembl chr 7:63,655,247...63,687,978

G

toll-like receptor 2

acts_upstream_of_or_within

MGI:2674036 (MGI:5299952|PMID:22033934)

NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061

Term paths to the root

Path 1
Term	Annotations
biological_process	19491
response to stimulus	10357
immune response	1926
defense response to other organism	1098
xenophagy	13
negative regulation of xenophagy	0
positive regulation of xenophagy	8
regulation of xenophagy +	8
Path 2
Term	Annotations
biological_process	19491
metabolic process	11797
catabolic process	2547
cellular catabolic process	2180
autophagy	460
macroautophagy	237
selective autophagy	73
xenophagy	13
negative regulation of xenophagy	0
positive regulation of xenophagy	8
regulation of xenophagy +	8

paths to the root