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ONTOLOGY REPORT - ANNOTATIONS


Term:xenophagy
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Accession:GO:0098792 term browser browse the term
Definition:The selective autophagy process in which a region of cytoplasm containing an intracellular pathogen or some part of an intracellular pathogen (e.g. viral capsid) is enclosed in a double membrane bound autophagosome, which then fuses with the lysosome leading to degradation of the contents.
Comment:While making xenophagy a subclass of (macro)autophagy may seem to directly contradict the definition of autophagy (literally self eating), it is clear that the same pathway is involved as in macroautophagy that doesn't target foreign material: formation of double-membrane-bounded autophagosomes that enclose a region of cytoplasm for degradation.



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xenophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07025818.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr16:48,598,506...48,599,444 JBrowse link
G Atg16l1 autophagy related 16-like 1 acts_upstream_of_or_within ISO PR:Q80W47 (MGI:5605433|PMID:24954904) RGD PMID:24954904 MGI:5605433 NCBI chr 9:88,420,737...88,457,530
Ensembl chr 9:88,422,038...88,457,529
JBrowse link
G Calcoco2 calcium binding and coiled-coil domain 2 involved_in ISO (PMID:25771791)
(PMID:23022382), (PMID:25771791)
RGD PMID:23022382 PMID:25771791 NCBI chr10:81,055,467...81,069,298 JBrowse link
G Lgals8 galectin 8 involved_in ISO
ISS
(PMID:22246324), (PMID:28077878)
GO_REF:0000024
RGD
GO_Central
PMID:22246324 PMID:28077878 GO_REF:0000024 NCBI chr17:58,024,652...58,052,764
Ensembl chr17:58,028,105...58,052,764
JBrowse link
G Mapk3 mitogen activated protein kinase 3 acts_upstream_of ISO MGI:1346858 (MGI:5299952|PMID:22033934) RGD PMID:22033934 MGI:5299952 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 acts_upstream_of ISO MGI:2674231 (MGI:5299952|PMID:22033934) RGD PMID:22033934 MGI:5299952 NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 acts_upstream_of ISO MGI:3529594 (MGI:5299952|PMID:22033934) RGD PMID:22033934 MGI:5299952 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of ISO MGI:2660793 (MGI:5299952|PMID:22033934) RGD PMID:22033934 MGI:5299952 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
JBrowse link
G Rnf213 ring finger protein 213 involved_in ISO (PMID:34012115) RGD PMID:34012115 NCBI chr10:104,656,329...104,755,669
Ensembl chr10:104,656,883...104,757,918
JBrowse link
G Tlr2 toll-like receptor 2 acts_upstream_of ISO MGI:2674036 (MGI:5299952|PMID:22033934) RGD PMID:22033934 MGI:5299952 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Wipi2 WD repeat domain, phosphoinositide interacting 2 acts_upstream_of_or_within ISO PR:Q8C0J2 (MGI:5605433|PMID:24954904) RGD PMID:24954904 MGI:5605433 NCBI chr12:11,911,369...11,939,799
Ensembl chr12:11,911,337...11,939,794
JBrowse link
positive regulation of xenophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrsam1 leucine rich repeat and sterile alpha motif containing 1 involved_in ISO (PMID:23245322) RGD PMID:23245322 NCBI chr 3:16,223,367...16,264,261
Ensembl chr 3:16,223,367...16,264,154
JBrowse link
G Mapk3 mitogen activated protein kinase 3 acts_upstream_of_or_within ISO MGI:1346858 (MGI:5299952|PMID:22033934) RGD PMID:22033934 MGI:5299952 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 acts_upstream_of_or_within ISO MGI:2674231 (MGI:5299952|PMID:22033934) RGD PMID:22033934 MGI:5299952 NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 acts_upstream_of_or_within ISO MGI:3529594 (MGI:5299952|PMID:22033934) RGD PMID:22033934 MGI:5299952 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Optn optineurin involved_in ISO
IEA
(PMID:21617041)
GO_REF:0000107
RGD
Ensembl
PMID:21617041 GO_REF:0000107 NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO MGI:2660793 (MGI:5299952|PMID:22033934) RGD PMID:22033934 MGI:5299952 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
JBrowse link
G Rnf31 ring finger protein 31 involved_in ISO (PMID:28481331) RGD PMID:28481331 NCBI chr15:29,083,047...29,095,328
Ensembl chr15:29,083,631...29,101,915
JBrowse link
G Tbk1 TANK-binding kinase 1 involved_in ISO (MGI:5645201|PMID:21617041) RGD PMID:21617041 MGI:5645201 NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
JBrowse link
G Tlr2 toll-like receptor 2 acts_upstream_of_or_within ISO MGI:2674036 (MGI:5299952|PMID:22033934) RGD PMID:22033934 MGI:5299952 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20099
    biological process involved in interspecies interaction between organisms 1893
      response to other organism 1756
        defense response to other organism 1210
          xenophagy 15
            negative regulation of xenophagy 0
            positive regulation of xenophagy 9
            regulation of xenophagy + 9
Path 2
Term Annotations click to browse term
  biological_process 20099
    metabolic process 12353
      catabolic process 2657
        cellular catabolic process 2129
          autophagy 508
            macroautophagy 267
              selective autophagy 94
                xenophagy 15
                  negative regulation of xenophagy 0
                  positive regulation of xenophagy 9
                  regulation of xenophagy + 9
paths to the root