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ONTOLOGY REPORT - ANNOTATIONS

Term:response to mitochondrial depolarisation
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Accession:GO:0098780 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to the depolarization of one or more mitochondria.


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response to mitochondrial depolarisation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMBRA1 autophagy and beclin 1 regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:46,355,026...46,556,091
Ensembl chr11:46,905,454...47,103,205 		JBrowse link
G ATG13 autophagy related 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:46,567,728...46,623,609
Ensembl chr11:47,126,380...47,182,850 		JBrowse link
G ATG14 autophagy related 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:35,953,228...35,998,650
Ensembl chr14:54,226,720...54,272,018 		JBrowse link
G BECN1 beclin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286 		JBrowse link
G GPS2 G protein pathway suppressor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:7,346,766...7,349,682
Ensembl chr17:7,333,571...7,335,871 		JBrowse link
G SQSTM1 sequestosome 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:174,960,727...174,989,946
Ensembl chr 5:182,284,436...182,299,093 		JBrowse link
G ULK1 unc-51 like autophagy activating kinase 1 involved_in ISO (MGI:5607224|PMID:21855797) BHF-UCL PMID:21855797 MGI:5607224 NCBI chr12:129,549,399...129,579,087 JBrowse link
negative regulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTRA2 HtrA serine peptidase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:74,596,020...74,599,790
Ensembl chr2A:76,102,240...76,106,152 		JBrowse link
negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VPS13C vacuolar protein sorting 13 homolog C involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:40,819,512...41,020,644
Ensembl chr15:59,119,001...59,319,619 		JBrowse link
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HDAC6 histone deacetylase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:41,099,539...41,122,650
Ensembl chr  X:48,960,430...48,982,642 		JBrowse link
G MFN2 mitofusin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:10,729,933...10,764,865
Ensembl chr 1:11,945,880...11,981,077 		JBrowse link
G OPTN optineurin involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:13,104,335...13,142,725
Ensembl chr10:13,077,345...13,115,773 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770 		JBrowse link
G SMURF1 SMAD specific E3 ubiquitin protein ligase 1 involved_in ISO (MGI:5298125|PMID:22020285) ParkinsonsUK-UCL PMID:22020285 MGI:5298125 NCBI chr 7:90,995,923...91,112,240
Ensembl chr 7:104,500,965...104,568,046 		JBrowse link
positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP5IF1 ATP synthase inhibitory factor subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:27,495,250...27,497,255
Ensembl chr 1:28,532,091...28,542,607 		JBrowse link
G GBA1 glucosylceramidase beta 1 acts_upstream_of_or_within ISO (MGI:5501380|PMID:23707074) ARUK-UCL PMID:23707074 MGI:5501380 NCBI chr 1:130,579,300...130,589,560
Ensembl chr 1:134,185,385...134,194,851 		JBrowse link
G HK2 hexokinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:74,897,914...74,957,234
Ensembl chr2A:76,400,240...76,460,874 		JBrowse link
G MUL1 mitochondrial E3 ubiquitin protein ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:19,454,792...19,463,527
Ensembl chr 1:20,496,356...20,505,281 		JBrowse link
G PINK1 PTEN induced kinase 1 ISO RGD PMID:25154397 RGD:12904014 NCBI chr 1:19,583,330...19,601,248
Ensembl chr 1:20,627,693...20,645,560 		JBrowse link
positive regulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC37 cell division cycle 37, HSP90 cochaperone involved_in ISO (MGI:5607224|PMID:21855797) ParkinsonsUK-UCL PMID:21855797 MGI:5607224 NCBI chr19:9,942,644...9,955,112
Ensembl chr19:10,606,246...10,618,702 		JBrowse link
G HDAC6 histone deacetylase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:41,099,539...41,122,650
Ensembl chr  X:48,960,430...48,982,642 		JBrowse link
G HUWE1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:45,746,228...45,897,250
Ensembl chr  X:53,855,404...54,005,366 		JBrowse link
G PINK1 PTEN induced kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:19,583,330...19,601,248
Ensembl chr 1:20,627,693...20,645,560 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770 		JBrowse link
G TOMM7 translocase of outer mitochondrial membrane 7 involved_in ISO (PMID:24270810) ParkinsonsUK-UCL PMID:24270810 NCBI chr 7:23,501,438...23,511,321
Ensembl chr 7:23,112,630...23,122,195 		JBrowse link
positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VDAC1 voltage dependent anion channel 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:129,375,267...129,408,230
Ensembl chr 5:135,529,173...135,560,005 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16313
    response to stimulus 8459
      response to stress 3892
        cellular response to stress 1892
          response to mitochondrial depolarisation 23
            regulation of autophagy of mitochondrion in response to mitochondrial depolarization + 16
paths to the root