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ONTOLOGY REPORT - ANNOTATIONS

Term:response to mitochondrial depolarisation
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Accession:GO:0098780 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to the depolarization of one or more mitochondria.


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response to mitochondrial depolarisation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ambra1 autophagy and beclin 1 regulator 1 involved_in ISO UniProtKB:Q9BXM7 (PMID:21753002), (PMID:25215947) RGD PMID:21753002 PMID:25215947 NCBI chr 3:77,700,936...77,890,221
Ensembl chr 3:77,700,936...77,890,221 		JBrowse link
G Atg13 autophagy related 13 involved_in ISO (MGI:5607224|PMID:21855797) RGD PMID:21855797 MGI:5607224 NCBI chr 3:77,647,069...77,681,028
Ensembl chr 3:77,645,790...77,681,043 		JBrowse link
G Atg14 autophagy related 14 involved_in ISO (PMID:23878393) RGD PMID:23878393 NCBI chr15:20,795,750...20,827,113
Ensembl chr15:20,795,750...20,827,113 		JBrowse link
G Becn1 beclin 1 involved_in ISO (PMID:23878393) RGD PMID:23878393 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Gps2 G protein pathway suppressor 2 involved_in ISO (MGI:6148396|PMID:29499132) RGD PMID:29499132 MGI:6148396 NCBI chr10:54,637,360...54,640,542
Ensembl chr10:54,637,455...54,640,650 		JBrowse link
G Sqstm1 sequestosome 1 involved_in ISO UniProtKB:Q9JK66 (PMID:20457763) RGD PMID:20457763 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 involved_in ISO (MGI:5607224|PMID:21855797) RGD PMID:21855797 MGI:5607224 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966 		JBrowse link
negative regulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htra2 HtrA serine peptidase 2 involved_in ISO (MGI:5581539|PMID:24709290) RGD PMID:24709290 MGI:5581539 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095 		JBrowse link
negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vps13c vacuolar protein sorting 13 homolog C involved_in ISO
ISS		 (PMID:26942284)
GO_REF:0000024		 RGD
ParkinsonsUK-UCL		 PMID:26942284 GO_REF:0000024 NCBI chr 8:68,478,366...68,651,893
Ensembl chr 8:68,478,395...68,651,895 		JBrowse link
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac6 histone deacetylase 6 involved_in ISO UniProtKB:Q9JK66|UniProtKB:Q9Z2V5 (PMID:20457763) RGD PMID:20457763 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Mfn2 mitofusin 2 involved_in ISO
IEA		 (MGI:5498413|PMID:23620051)
GO_REF:0000107		 RGD
Ensembl		 PMID:23620051 GO_REF:0000107 MGI:5498413 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Optn optineurin involved_in ISO
IEA		 (PMID:25294927)
GO_REF:0000107		 RGD
Ensembl		 PMID:25294927 GO_REF:0000107 NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO
IEA		 (PMID:19029340)
GO_REF:0000107		 RGD
Ensembl		 PMID:19029340 GO_REF:0000107 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 involved_in ISO (MGI:5298125|PMID:22020285) RGD PMID:22020285 MGI:5298125 NCBI chr12:9,635,009...9,726,520
Ensembl chr12:9,635,025...9,726,519 		JBrowse link
positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5if1 ATP synthase inhibitory factor subunit 1 involved_in ISO (PMID:24005319) RGD PMID:24005319 NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668 		JBrowse link
G Gba1 glucosylceramidase beta 1 acts_upstream_of_or_within ISO (MGI:5501380|PMID:23707074) RGD PMID:23707074 MGI:5501380 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263 		JBrowse link
G Hk2 hexokinase 2 involved_in ISO (PMID:23962723) RGD PMID:23962723 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 involved_in ISO (MGI:5581539|PMID:24709290) RGD PMID:24709290 MGI:5581539 NCBI chr 5:150,652,812...150,661,863
Ensembl chr 5:150,652,812...150,661,863 		JBrowse link
G Pink1 PTEN induced kinase 1 IMP RGD PMID:25154397 RGD:12904014 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
positive regulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc37 cell division cycle 37, HSP90 cochaperone involved_in ISO
IEA		 (MGI:5607224|PMID:21855797)
GO_REF:0000107		 RGD
Ensembl		 PMID:21855797 GO_REF:0000107 MGI:5607224 NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809 		JBrowse link
G Hdac6 histone deacetylase 6 involved_in ISO UniProtKB:Q9JK66 (MGI:5616310|PMID:20457763) RGD PMID:20457763 MGI:5616310 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441 		JBrowse link
G Huwe1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 involved_in ISO (PMID:30217973) RGD PMID:30217973 NCBI chr  X:20,873,795...21,001,378
Ensembl chr  X:20,873,795...21,001,262 		JBrowse link
G Pink1 PTEN induced kinase 1 involved_in ISO (PMID:20871098) RGD PMID:20871098 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO (PMID:20457763), (PMID:20871098), (PMID:23212910) RGD PMID:20457763 PMID:20871098 PMID:23212910 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Tomm7 translocase of outer mitochondrial membrane 7 involved_in ISO (PMID:24270810) RGD PMID:24270810 NCBI chr 4:11,305,122...11,311,963
Ensembl chr 4:11,305,110...11,311,962 		JBrowse link
positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vdac1 voltage-dependent anion channel 1 involved_in ISO (PMID:32047033) RGD PMID:32047033 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19553
    response to stimulus 10408
      response to stress 4215
        cellular response to stress 2097
          response to mitochondrial depolarisation 23
            regulation of autophagy of mitochondrion in response to mitochondrial depolarization + 16
paths to the root