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ONTOLOGY REPORT - ANNOTATIONS

Term:ferroptosis
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Accession:GO:0097707 term browser browse the term
Definition:A programmed cell death characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter are involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism. Glutathione peroxidase 4 (GPX4), heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes.
Synonyms:related_synonym: iron-dependent programmed cell death


show annotations for term's descendants           Sort by:
negative regulation of ferroptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIFM2 apoptosis inducing factor mitochondria associated 2 involved_in ISO (PMID:31634899), (PMID:31634900)
(PMID:35922516)		 UniProt PMID:31634899 PMID:31634900 PMID:35922516 NCBI chr 4:21,086,778...21,104,127
Ensembl chr 4:21,087,339...21,104,172 		JBrowse link
G FTH1 ferritin heavy chain 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr11:39,037,349...39,038,170
Ensembl chr11:39,037,318...39,038,079 		JBrowse link
G FTH1 ferritin heavy chain 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr18:54,466,167...54,468,733
Ensembl chr18:54,466,023...54,468,732 		JBrowse link
G GPX4 glutathione peroxidase 4 involved_in IEA Ensembl GO_REF:0000107
G HMOX1 heme oxygenase 1 involved_in ISO (PMID:26403645) UniProt PMID:26403645 NCBI chr10:28,744,404...28,751,544
Ensembl chr10:28,743,795...28,751,773 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 involved_in ISO (PMID:26403645) UniProt PMID:26403645 NCBI chr36:20,989,205...21,087,044
Ensembl chr36:20,989,360...21,012,524 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 involved_in ISO (PMID:26403645) UniProt PMID:26403645 NCBI chr 5:79,979,593...79,990,875
Ensembl chr 5:79,978,865...79,989,860 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:4,289,792...4,379,060
Ensembl chr19:4,289,850...4,389,048 		JBrowse link
G SQSTM1 sequestosome 1 involved_in ISO (PMID:26403645) UniProt PMID:26403645 NCBI chr11:1,859,776...1,869,289
Ensembl chr11:1,859,465...1,870,755 		JBrowse link
positive regulation of ferroptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR23A microRNA mir-23a ISO RGD PMID:33403590 RGD:155882539 NCBI chr20:48,620,335...48,620,386
Ensembl chr20:48,620,323...48,620,397 		JBrowse link
G TMEM164 transmembrane protein 164 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:83,219,530...83,384,900
Ensembl chr  X:83,219,505...83,381,564 		JBrowse link
regulation of ferroptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC39A7 solute carrier family 39 member 7 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr12:2,663,807...2,667,527
Ensembl chr12:2,663,515...2,669,917 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17917
    cellular process 16926
      cell death 2083
        programmed cell death 2083
          ferroptosis 12
            negative regulation of ferroptosis 9
            positive regulation of ferroptosis 2
            regulation of ferroptosis + 12
paths to the root