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ONTOLOGY REPORT - ANNOTATIONS

Term:double-strand break repair via alternative nonhomologous end joining
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Accession:GO:0097681 term browser browse the term
Definition:An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment.
Synonyms:exact_synonym: double-strand break repair via microhomology-mediated end joining
 related_synonym: A-NHEJ;   MMEJ;   alt-NHEJ


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double-strand break repair via alternative nonhomologous end joining term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Helq helicase, POLQ-like involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:100,910,010...100,946,529
Ensembl chr 5:100,910,011...100,946,464 		JBrowse link
G Hmces 5-hydroxymethylcytosine (hmC) binding, ES cell specific involved_in IDA (MGI:6393148|PMID:31806351) UniProt PMID:31806351 MGI:6393148 NCBI chr 6:87,890,889...87,913,603
Ensembl chr 6:87,890,917...87,913,611 		JBrowse link
G Lig3 ligase III, DNA, ATP-dependent involved_in IMP
ISO		 (MGI:5014103|PMID:21655080) BHF-UCL
MGI		 PMID:21655080 GO_REF:0000119 MGI:4834177 MGI:5014103 NCBI chr11:82,671,977...82,695,100
Ensembl chr11:82,671,934...82,695,100 		JBrowse link
G Nbn nibrin involved_in ISO
IDA		 (MGI:6269043|PMID:28216226) MGI
UniProt		 PMID:28216226 GO_REF:0000119 MGI:4834177 MGI:6269043 NCBI chr 4:15,955,388...15,992,589
Ensembl chr 4:15,957,925...15,992,589 		JBrowse link
G Plk1 polo like kinase 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:121,758,658...121,769,107
Ensembl chr 7:121,758,662...121,769,096 		JBrowse link
G Polq polymerase (DNA directed), theta involved_in IDA
ISO
IBA		 (MGI:5621198|PMID:25642960), (MGI:6869820|PMID:29058711) UniProt
MGI
GO_Central		 PMID:25642960 PMID:29058711 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:5621198 MGI:6869820 NCBI chr16:36,832,104...36,922,321
Ensembl chr16:36,832,148...36,915,779 		JBrowse link
G Rhno1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 6:128,333,962...128,339,876
Ensembl chr 6:128,333,963...128,339,874 		JBrowse link
G Topbp1 topoisomerase (DNA) II binding protein 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 9:103,182,351...103,227,627
Ensembl chr 9:103,182,414...103,227,627 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    response to stimulus 10772
      response to stress 4448
        cellular response to stress 2064
          DNA damage response 915
            DNA repair 600
              double-strand break repair 313
                double-strand break repair via nonhomologous end joining 74
                  double-strand break repair via alternative nonhomologous end joining 8
Path 2
Term Annotations click to browse term
  biological_process 28573
    metabolic process 11001
      organic substance metabolic process 10573
        organic cyclic compound metabolic process 5906
          nucleobase-containing compound metabolic process 5390
            nucleic acid metabolic process 4826
              DNA metabolic process 987
                DNA repair 600
                  double-strand break repair 313
                    double-strand break repair via nonhomologous end joining 74
                      double-strand break repair via alternative nonhomologous end joining 8
paths to the root