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ONTOLOGY REPORT - ANNOTATIONS

Term:double-strand break repair via classical nonhomologous end joining
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Accession:GO:0097680 term browser browse the term
Definition:An instance of double-strand break repair via nonhomologous end joining that requires a number of factors important for V(D)J recombination, including the KU70/80 heterodimer (KU), XRCC4, ligase IV, and DNA-PKcs in mammals. It does not produce translocations (as opposed to the alternative nonhomologous end joining).
Synonyms:exact_synonym: canonical nonhomologous end joining
 related_synonym: C-NHEJ


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double-strand break repair via classical nonhomologous end joining term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERCC6 ERCC excision repair 6, chromatin remodeling factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:44,703,720...44,784,948 JBrowse link
G ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:53,053,712...53,131,563
Ensembl chr 5:54,693,987...54,765,496 		JBrowse link
G LIG4 DNA ligase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:89,336,434...89,347,418
Ensembl chr13:108,475,820...108,478,555 		JBrowse link
G RNF168 ring finger protein 168 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:193,814,785...193,848,620
Ensembl chr 3:203,756,589...203,790,687 		JBrowse link
G TOPBP1 DNA topoisomerase II binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:130,667,998...130,729,569
Ensembl chr 3:138,143,893...138,203,363 		JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:22,364,696...22,472,499
Ensembl chr15:40,519,012...40,626,741 		JBrowse link
G UVRAG UV radiation resistance associated involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:70,870,341...71,197,559
Ensembl chr11:74,172,919...74,496,046 		JBrowse link
G XRCC6 X-ray repair cross complementing 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:22,516,281...22,557,379
Ensembl chr22:40,603,038...40,643,314 		JBrowse link
G ZBTB7A zinc finger and BTB domain containing 7A involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:3,066,554...3,090,285 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16440
    response to stimulus 8500
      response to stress 3906
        cellular response to stress 1899
          DNA damage response 824
            DNA repair 513
              double-strand break repair 295
                double-strand break repair via nonhomologous end joining 75
                  double-strand break repair via classical nonhomologous end joining 9
Path 2
Term Annotations click to browse term
  biological_process 16440
    metabolic process 10303
      organic substance metabolic process 9869
        organic cyclic compound metabolic process 5562
          nucleobase-containing compound metabolic process 5109
            nucleic acid metabolic process 4613
              DNA metabolic process 917
                DNA repair 513
                  double-strand break repair 295
                    double-strand break repair via nonhomologous end joining 75
                      double-strand break repair via classical nonhomologous end joining 9
paths to the root