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ONTOLOGY REPORT - ANNOTATIONS


Term:serpin family protein binding
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Accession:GO:0097655 term browser browse the term
Definition:Binding to a member of the serpin protein family (serine protease inhibitors or classified inhibitor family I4). Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades. The majority of serpins inhibit serine proteases, but serpins that inhibit caspases and papain-like cysteine proteases have also been identified. Rarely, serpins perform a non-inhibitory function; for example, several human serpins function as hormone transporters and certain serpins function as molecular chaperones or tumor suppressors.



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serpin family protein binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsl cathepsin L enables ISO UniProtKB:P29508 (PMID:21383048) RGD PMID:21383048 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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  molecular_function 19910
    binding 16997
      protein binding 14384
        serpin family protein binding 1
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