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ONTOLOGY REPORT - ANNOTATIONS

Term:PTEX complex
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Accession:GO:0097619 term browser browse the term
Definition:A protein complex that acts as a protein trafficking machinery and is responsible for the export of proteins across the parasitophorous (symbiont-containing) vacuolar membrane and into the human host cell. The PTEX complex is located in the vacuole membrane. It is ATP-powered, and comprises heat shock protein 101 (HSP101; a ClpA/B-like ATPase from the AAA+ superfamily, of a type commonly associated with protein translocons), a parasite protein termed PTEX150, and exported protein 2 (EXP2). EXP2 is the potential channel, as it is the membrane-associated component of the core PTEX complex. Two other proteins, PTEX88 and thioredoxin 2 (TRX2), were also identified as PTEX components.
Synonyms:related_synonym: Plasmodium translocon of exported proteins
 only_in_taxon: NCBITaxon:5820 ! Plasmodium


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  cellular_component 18903
    protein-containing complex 6509
      PTEX complex 0
Path 2
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  cellular_component 18903
    cellular anatomical entity 18651
      host cellular component 1
        host cell part 0
          host intracellular region 0
            host intracellular part 0
              host cell cytoplasm 0
                host cell cytoplasm part 0
                  symbiont-containing vacuole 0
                    symbiont-containing vacuole membrane 0
                      PTEX complex 0
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