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ONTOLOGY REPORT - ANNOTATIONS

Term:ubiquitin-dependent glycoprotein ERAD pathway
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Accession:GO:0097466 term browser browse the term
Definition:An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component.
Synonyms:exact_synonym: ER-associated glycoprotein degradation;   glycoprotein ERAD;   gpERAD
 broad_synonym: misfolded or incompletely synthesized glycoprotein catabolic process


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ubiquitin-dependent glycoprotein ERAD pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edem3 ER degradation enhancing alpha-mannosidase like protein 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:63,858,282...63,920,538
Ensembl chr13:63,858,716...63,920,523 		JBrowse link
mannose trimming involved in glycoprotein ERAD pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Man1a1 mannosidase, alpha, class 1A, member 1 involved_in ISO (PMID:27108681) RGD PMID:27108681 NCBI chr20:33,745,158...33,928,584
Ensembl chr20:33,202,517...33,385,824 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20536
    response to stimulus 11014
      response to chemical 5936
        response to nitrogen compound 1591
          response to glycoprotein 12
            ubiquitin-dependent glycoprotein ERAD pathway 2
              mannose trimming involved in glycoprotein ERAD pathway 1
Path 2
Term Annotations click to browse term
  biological_process 20536
    cellular process 19525
      metabolic process 12160
        catabolic process 2919
          macromolecule catabolic process 1678
            protein catabolic process 1199
              proteolysis involved in protein catabolic process 930
                proteasomal protein catabolic process 645
                  ERAD pathway 111
                    ubiquitin-dependent glycoprotein ERAD pathway 2
                      mannose trimming involved in glycoprotein ERAD pathway 1
paths to the root