Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:ubiquitin-dependent glycoprotein ERAD pathway
go back to main search page
Accession:GO:0097466 term browser browse the term
Definition:An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component.
Synonyms:exact_synonym: ER-associated glycoprotein degradation;   glycoprotein ERAD;   gpERAD
 broad_synonym: misfolded or incompletely synthesized glycoprotein catabolic process


show annotations for term's descendants           Sort by:
ubiquitin-dependent glycoprotein ERAD pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 involved_in ISO (PMID:21062743), (PMID:25092655) RGD PMID:21062743 PMID:25092655 NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717 		JBrowse link
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 involved_in ISO (PMID:15537790) RGD PMID:15537790 NCBI chr 3:144,201,604...144,227,423
Ensembl chr 3:144,201,605...144,227,485 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19574
    response to stimulus 10408
      response to chemical 5925
        response to oxygen-containing compound 2559
          response to glycoprotein 11
            ubiquitin-dependent glycoprotein ERAD pathway 2
              mannose trimming involved in glycoprotein ERAD pathway 0
Path 2
Term Annotations click to browse term
  biological_process 19574
    metabolic process 11556
      organic substance metabolic process 10908
        macromolecule metabolic process 9179
          protein metabolic process 4654
            proteolysis 1522
              proteolysis involved in protein catabolic process 769
                modification-dependent protein catabolic process 640
                  ubiquitin-dependent protein catabolic process 625
                    proteasome-mediated ubiquitin-dependent protein catabolic process 443
                      ubiquitin-dependent ERAD pathway 80
                        ubiquitin-dependent glycoprotein ERAD pathway 2
                          mannose trimming involved in glycoprotein ERAD pathway 0
paths to the root