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ONTOLOGY REPORT - ANNOTATIONS


Term:GAIT complex
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Accession:GO:0097452 term browser browse the term
Definition:A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP.
Synonyms:exact_synonym: IFN-gamma-activated inhibitor of translation complex;   gamma interferon-activated inhibitor of translation complex



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GAIT complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eprs glutamyl-prolyl-tRNA synthetase part_of
NOT|part_of
ISO (PMID:15479637), (PMID:23071094)
(MGI:5466658|PMID:23071094)
RGD PMID:15479637 PMID:23071094 MGI:5466658 NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase part_of ISO
ISS
(PMID:15479637), (PMID:23071094)
GO_REF:0000024
(MGI:5466658|PMID:23071094)
RGD
UniProt
PMID:15479637 PMID:23071094 GO_REF:0000024 MGI:5466658 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Rpl13a ribosomal protein L13A part_of
NOT|part_of
ISO
ISS
(PMID:15479637), (PMID:23071094)
GO_REF:0000024
(MGI:5466658|PMID:23071094)
RGD
UniProt
PMID:15479637 PMID:23071094 GO_REF:0000024 MGI:5466658 NCBI chr 1:95,609,374...95,612,557
Ensembl chr 1:95,609,370...95,620,463
JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein part_of ISO
IEA
(PMID:15479637), (PMID:23071094)
GO_REF:0000107
RGD
Ensembl
PMID:15479637 PMID:23071094 GO_REF:0000107 NCBI chr 8:89,402,487...89,435,517
Ensembl chr 8:89,402,866...89,435,515
JBrowse link

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  cellular_component 19309
    protein-containing complex 5988
      GAIT complex 4
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