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ONTOLOGY REPORT - ANNOTATIONS

Term:GAIT complex
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Accession:GO:0097452 term browser browse the term
Definition:A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP.
Synonyms:exact_synonym: IFN-gamma-activated inhibitor of translation complex;   gamma interferon-activated inhibitor of translation complex


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GAIT complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eprs1 glutamyl-prolyl-tRNA synthetase 1 part_of ISO (PMID:15479637), (PMID:23071094)
(PMID:23071094)		 RGD PMID:15479637 PMID:23071094 NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase part_of ISO
ISS		 (PMID:15479637), (PMID:23071094)
GO_REF:0000024
(PMID:23071094)		 RGD
UniProt		 PMID:15479637 PMID:23071094 GO_REF:0000024 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Rpl13a ribosomal protein L13A part_of ISO
ISS		 (PMID:15479637), (PMID:23071094)
GO_REF:0000024
(PMID:23071094)		 RGD
UniProt		 PMID:15479637 PMID:23071094 GO_REF:0000024 NCBI chr 1:95,609,374...95,612,557
Ensembl chr 1:95,609,370...95,620,463 		JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein part_of ISO
IEA		 (PMID:15479637), (PMID:23071094)
GO_REF:0000107		 RGD
Ensembl		 PMID:15479637 PMID:23071094 GO_REF:0000107 NCBI chr 8:89,402,487...89,435,517
Ensembl chr 8:89,402,866...89,435,515 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21321
    protein-containing complex 6790
      GAIT complex 4
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