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ONTOLOGY REPORT - ANNOTATIONS


Term:GAIT complex
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Accession:GO:0097452 term browser browse the term
Definition:A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP.
Synonyms:exact_synonym: IFN-gamma-activated inhibitor of translation complex;   gamma interferon-activated inhibitor of translation complex


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GAIT complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eprs glutamyl-prolyl-tRNA synthetase part_of
NOT|part_of
ISO (PMID:15479637), (PMID:23071094)
(MGI:5466658|PMID:23071094)
RGD PMID:15479637 PMID:23071094 MGI:5466658 NCBI chr13:103,300,911...103,371,651
Ensembl chr13:103,300,932...103,371,577
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase part_of ISO
ISS
(PMID:15479637), (PMID:23071094)
(MGI:5466658|PMID:23071094)
GO_REF:0000024
RGD
UniProt
PMID:15479637 PMID:23071094 GO_REF:0000024 MGI:5466658 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G LOC108351137 glyceraldehyde-3-phosphate dehydrogenase part_of ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 5:115,649,077...115,650,141
Ensembl chr 5:115,649,046...115,650,340
Ensembl chr 4:115,649,046...115,650,340
JBrowse link
G Rpl13a ribosomal protein L13A part_of
NOT|part_of
ISO
ISS
(PMID:15479637), (PMID:23071094)
(MGI:5466658|PMID:23071094)
GO_REF:0000024
RGD
UniProt
PMID:15479637 PMID:23071094 GO_REF:0000024 MGI:5466658 NCBI chr 1:101,120,325...101,123,401
Ensembl chr 1:101,120,325...101,123,402
JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein part_of ISO (PMID:15479637), (PMID:23071094) RGD PMID:15479637 PMID:23071094 NCBI chr 8:96,100,692...96,266,342
Ensembl chr 8:96,105,025...96,266,342
JBrowse link

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  cellular_component 20142
    protein-containing complex 6031
      GAIT complex 5
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