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ONTOLOGY REPORT - ANNOTATIONS

Term:neurofibrillary tangle
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Accession:GO:0097418 term browser browse the term
Definition:Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star.
Comment:Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267).
Synonyms:narrow_synonym: flame-shaped neurofibrillary tangle;   star-shaped neurofibrillary tangle
 xref: NIF_Subcellular:nlx_subcell_20090201;   NIF_Subcellular:nlx_subcell_20090202;   NIF_Subcellular:sao2409833926
 only_in_taxon: NCBITaxon:33208 ! Metazoa

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neurofibrillary tangle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clu clusterin located_in ISO (PMID:15897157), (PMID:9560017) Alzheimers_University_of_Toronto PMID:9560017 PMID:15897157 NCBI chrNW_004955403:50,160,598...50,175,876
Ensembl chrNW_004955403:50,160,598...50,175,876 		JBrowse link
G Mapt microtubule associated protein tau located_in ISO (PMID:2484340) CAFA PMID:2484340 NCBI chrNW_004955478:10,222,439...10,271,439
Ensembl chrNW_004955478:10,225,823...10,271,442 		JBrowse link
G Nefh neurofilament heavy chain located_in ISO (PMID:21828286) BHF-UCL PMID:21828286 NCBI chrNW_004955455:3,735,330...3,744,714
Ensembl chrNW_004955455:3,735,410...3,744,107 		JBrowse link
G Nefm neurofilament medium chain located_in ISO (PMID:21828286) BHF-UCL PMID:21828286 NCBI chrNW_004955403:47,920,408...47,926,922 JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein located_in ISO (PMID:23589030) Alzheimers_University_of_Toronto PMID:23589030 NCBI chrNW_004955414:6,871,220...6,970,569
Ensembl chrNW_004955414:6,871,520...6,969,208 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 12554
    cellular anatomical entity 12397
      intracellular anatomical structure 10515
        inclusion body 73
          neurofibrillary tangle 5
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