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ONTOLOGY REPORT - ANNOTATIONS


Term:neurofibrillary tangle
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Accession:GO:0097418 term browser browse the term
Definition:Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star.
Comment:Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267).
Synonyms:narrow_synonym: flame-shaped neurofibrillary tangle;   star-shaped neurofibrillary tangle
 xref: NIF_Subcellular:nlx_subcell_20090201;   NIF_Subcellular:nlx_subcell_20090202;   NIF_Subcellular:sao2409833926
 only_in_taxon: NCBITaxon:33208 ! Metazoa



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neurofibrillary tangle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clu clusterin located_in ISO
ISS
IEA
(PMID:15897157), (PMID:9560017)
GO_REF:0000024
GO_REF:0000107
RGD
Alzheimers_University_of_Toronto
Ensembl
PMID:9560017 PMID:15897157 GO_REF:0000024 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Mapt microtubule-associated protein tau located_in ISO (PMID:2484340) RGD PMID:2484340 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Nefh neurofilament heavy chain located_in ISO (PMID:21828286) RGD PMID:21828286 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nefm neurofilament medium chain located_in IEA
ISO
GO_REF:0000107
(PMID:21828286)
Ensembl
RGD
PMID:21828286 GO_REF:0000107 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein located_in IEA
ISO
ISS
GO_REF:0000107
(PMID:23589030)
GO_REF:0000024
Ensembl
RGD
Alzheimers_University_of_Toronto
PMID:23589030 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557
JBrowse link

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  cellular_component 20621
    cellular anatomical entity 20375
      intracellular anatomical structure 14848
        inclusion body 84
          neurofibrillary tangle 5
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