hypoxia-inducible factor-1alpha signaling pathway - Ontology Report - Rat Genome Database

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS	{{ watchLinkText }}

Term:	hypoxia-inducible factor-1alpha signaling pathway	go back to main search page
Accession:	GO:0097411	browse the term
Definition:	The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia.
Synonyms:	exact_synonym:	HIF1alpha pathway; hypoxia-inducible factor signaling; hypoxia-inducible factor-1alpha signalling pathway

show annotations for term's descendants Sort by:
Rat (8) Mouse (8) Human (8) Chinchilla (7) Bonobo (7) Dog (7) Squirrel (7) Pig (7) Green Monkey (8) Naked Mole-rat (7) All
Genes (8)

hypoxia-inducible factor-1alpha signaling pathway

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome b-245 beta chain

RGD

NCBI chr X:13,360,583...13,392,517
Ensembl chr X:13,359,430...13,392,586

G

hypoxia inducible factor 1 subunit alpha

involved_in
acts_upstream_of_or_within

GO_REF:0000107
(MGI:60478|PMID:8470821)

GO_REF:0000107 MGI:60478

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

microRNA 210

involved_in

(PMID:19782034)

NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454

G

pyruvate dehydrogenase kinase 1

involved_in

GO_REF:0000107
(PMID:21763680)
GO_REF:0000024

Ensembl
RGD
UniProt

GO_REF:0000024 GO_REF:0000107

NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038

G

pyruvate dehydrogenase kinase 3

involved_in

(PMID:18718909)

NCBI chr X:58,477,471...58,553,932
Ensembl chr X:58,486,554...58,553,557

G

von Hippel-Lindau tumor suppressor

acts_upstream_of

MGI:2136645|MGI:3608931 (MGI:5618205|PMID:25186293)

NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377

negative regulation of hypoxia-inducible factor-1alpha signaling pathway

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

copper metabolism domain containing 1

acts_upstream_of_or_within

MGI:3714157 (MGI:3713589|PMID:17371845)

NCBI chr14:96,880,463...96,984,494
Ensembl chr14:96,880,463...96,984,501

G

von Hippel-Lindau tumor suppressor

acts_upstream_of_or_within

MGI:2136645|MGI:3608931 (MGI:5618205|PMID:25186293)

NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377

positive regulation of hypoxia-inducible factor-1alpha signaling pathway

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RWD domain containing 3

acts_upstream_of_or_within
involved_in

ISO
IEA
ISS
IBA

(MGI:5569907|PMID:22009797)
GO_REF:0000002
GO_REF:0000024
(PMID:23469069)
PMID:21873635

RGD
InterPro
UniProt

PMID:22009797 PMID:23469069 PMID:21873635

GO_REF:0000002 GO_REF:0000024 MGI:5569907, RGD:13792537

NCBI chr 2:209,233,622...209,254,842
Ensembl chr 2:209,233,622...209,248,853

Term paths to the root

Path 1
Term	Annotations
biological_process	19746
cellular process	18159
signal transduction	7033
hypoxia-inducible factor-1alpha signaling pathway	8
negative regulation of hypoxia-inducible factor-1alpha signaling pathway	2
positive regulation of hypoxia-inducible factor-1alpha signaling pathway	1
regulation of hypoxia-inducible factor-1alpha signaling pathway +	3
Path 2
Term	Annotations
biological_process	19746
response to stimulus	10448
cellular response to stimulus	8828
cellular response to chemical stimulus	3248
cellular response to oxygen levels	268
cellular response to decreased oxygen levels	248
cellular response to hypoxia	217
hypoxia-inducible factor-1alpha signaling pathway	8
negative regulation of hypoxia-inducible factor-1alpha signaling pathway	2
positive regulation of hypoxia-inducible factor-1alpha signaling pathway	1
regulation of hypoxia-inducible factor-1alpha signaling pathway +	3

paths to the root