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ONTOLOGY REPORT - ANNOTATIONS


Term:hypoxia-inducible factor-1alpha signaling pathway
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Accession:GO:0097411 term browser browse the term
Definition:A series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia.
Synonyms:exact_synonym: HIF1alpha pathway;   hypoxia-inducible factor signaling;   hypoxia-inducible factor-1alpha signalling pathway



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hypoxia-inducible factor-1alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cybb cytochrome b-245 beta chain IMP RGD PMID:21302291 RGD:11040609 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:60478|PMID:8470821)
Ensembl
RGD
PMID:8470821 GO_REF:0000107 MGI:60478 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:21763680)
UniProt
Ensembl
RGD
PMID:21763680 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 involved_in ISO (PMID:18718909) RGD PMID:18718909 NCBI chr  X:58,477,471...58,553,932
Ensembl chr  X:58,486,554...58,553,557
JBrowse link
negative regulation of hypoxia-inducible factor-1alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Commd1 copper metabolism domain containing 1 acts_upstream_of_or_within ISO MGI:3714157 (MGI:3713589|PMID:17371845) RGD PMID:17371845 MGI:3713589 NCBI chr14:96,880,463...96,984,494
Ensembl chr14:96,880,463...96,984,501
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor acts_upstream_of_or_within ISO MGI:2136645|MGI:3608931 (MGI:5618205|PMID:25186293) RGD PMID:25186293 MGI:5618205 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377
JBrowse link
positive regulation of hypoxia-inducible factor-1alpha signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rwdd3 RWD domain containing 3 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(PMID:23469069)
(MGI:5569907|PMID:22009797)
UniProt
RGD
PMID:22009797 PMID:23469069 GO_REF:0000024 MGI:5569907 NCBI chr 2:209,233,622...209,254,842
Ensembl chr 2:209,233,622...209,248,853
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    cellular process 18359
      signal transduction 6908
        hypoxia-inducible factor-1alpha signaling pathway 7
          negative regulation of hypoxia-inducible factor-1alpha signaling pathway 2
          positive regulation of hypoxia-inducible factor-1alpha signaling pathway 1
          regulation of hypoxia-inducible factor-1alpha signaling pathway + 3
Path 2
Term Annotations click to browse term
  biological_process 19497
    response to stimulus 10416
      cellular response to stimulus 8783
        cellular response to chemical stimulus 3562
          cellular response to oxygen levels 239
            cellular response to decreased oxygen levels 218
              cellular response to hypoxia 188
                hypoxia-inducible factor-1alpha signaling pathway 7
                  negative regulation of hypoxia-inducible factor-1alpha signaling pathway 2
                  positive regulation of hypoxia-inducible factor-1alpha signaling pathway 1
                  regulation of hypoxia-inducible factor-1alpha signaling pathway + 3
paths to the root