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ONTOLOGY REPORT - ANNOTATIONS


Term:synaptic vesicle lumen acidification
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Accession:GO:0097401 term browser browse the term
Definition:The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading.
Synonyms:exact_synonym: synaptic vesicle lumen pH reduction;   synaptic vesicle proton loading


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synaptic vesicle lumen acidification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6v1b1 ATPase H+ transporting V1 subunit B1 IC GO_REF:0000111 SynGO GO_REF:0000111 NCBI chr 4:115,417,100...115,435,754
Ensembl chr 4:115,416,580...115,437,206
JBrowse link
G Clcn3 chloride voltage-gated channel 3 ISO MGI:MGI:2447864 (MGI:MGI:2182197|PMID:11182090), (MGI:MGI:5006894|PMID:21378974) RGD PMID:11182090, PMID:21378974 MGI:MGI:2182197, MGI:MGI:5006894 NCBI chr16:32,448,821...32,520,649
Ensembl chr16:32,449,116...32,519,148
JBrowse link
G Slc17a7 solute carrier family 17 member 7 ISO MGI:MGI:3051945 (MGI:MGI:3836822|PMID:19169251) RGD PMID:19169251 MGI:MGI:3836822 NCBI chr 1:101,161,265...101,172,292
Ensembl chr 1:101,161,252...101,173,174
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    cellular process 18791
      cellular homeostasis 1045
        neuron cellular homeostasis 39
          synaptic vesicle lumen acidification 3
            negative regulation of synaptic vesicle lumen acidification 0
            positive regulation of synaptic vesicle lumen acidification 0
            regulation of synaptic vesicle lumen acidification + 0
Path 2
Term Annotations click to browse term
  biological_process 20017
    localization 6486
      establishment of localization 4918
        transport 4774
          ion transport 1782
            cation transport 1281
              cation transmembrane transport 920
                inorganic cation transmembrane transport 803
                  proton transmembrane transport 165
                    synaptic vesicle lumen acidification 3
                      negative regulation of synaptic vesicle lumen acidification 0
                      positive regulation of synaptic vesicle lumen acidification 0
                      regulation of synaptic vesicle lumen acidification + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.