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ONTOLOGY REPORT - ANNOTATIONS


Term:mitochondrial outer membrane permeabilization
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Accession:GO:0097345 term browser browse the term
Definition:The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway.
Comment:BAX and BAK are involved in this process, as reviewed in PMID:21760595 (the human proteins have UniProt symbols Q07812 and Q16611 respectively).
Synonyms:exact_synonym: MOMP;   mitochondrion outer membrane permeabilization
 broad_synonym: mitochondrial outer membrane permeabilization during apoptotic cell death



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mitochondrial outer membrane permeabilization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BID BH3 interacting domain death agonist involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5566519|PMID:20436477) Ensembl
Ensembl
MGI
PMID:20436477 GO_REF:0000107 MGI:5566519 NCBI chr 5:69,849,007...69,874,647
Ensembl chr 5:69,849,002...69,875,853
JBrowse link
G BLOC1S2 biogenesis of lysosomal organelles complex 1 subunit 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr14:111,391,083...111,397,609
Ensembl chr14:111,388,898...111,397,594
JBrowse link
G BNIP3 BCL2 interacting protein 3 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr14:140,362,123...140,371,951
Ensembl chr14:140,362,127...140,371,907
JBrowse link
G BNIP3L BCL2 interacting protein 3 like involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr14:10,318,688...10,345,689
Ensembl chr14:10,318,732...10,345,679
JBrowse link
G EYA2 EYA transcriptional coactivator and phosphatase 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2158099|PMID:11700312) Ensembl
Ensembl
MGI
PMID:11700312 GO_REF:0000107 MGI:2158099 NCBI chr17:48,930,682...49,243,789
Ensembl chr17:48,966,814...49,243,739
JBrowse link
G RHOT1 ras homolog family member T1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr12:42,711,231...42,783,471
Ensembl chr12:42,711,233...42,783,421
JBrowse link
G RHOT2 ras homolog family member T2 involved_in ISS UniProt
UniProt
GO_REF:0000024 NCBI chr 3:41,100,876...41,106,370
Ensembl chr 3:41,100,879...41,106,418
JBrowse link
G RTL10 retrotransposon Gag like 10 involved_in ISO (PMID:23055042) UniProt PMID:23055042 NCBI chr14:51,338,134...51,342,383 JBrowse link
G VDAC2 voltage dependent anion channel 2 involved_in ISS
IEA
UniProt
Ensembl
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr14:77,767,165...77,782,327
Ensembl chr14:77,766,686...77,782,322
JBrowse link
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAA2 acetyl-CoA acyltransferase 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 1:99,284,467...99,310,759
Ensembl chr 1:99,284,140...99,311,321
JBrowse link
G BAK1 BCL2 antagonist/killer 1 involved_in ISO (PMID:15901672) ComplexPortal PMID:15901672 NCBI chr 7:29,808,849...29,815,345 JBrowse link
G BCL2L1 BCL2 like 1 involved_in ISO (PMID:9393856)
(PMID:15901672), (PMID:9393856)
ComplexPortal PMID:9393856 PMID:15901672 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694
JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr15:140,171,134...140,184,126
Ensembl chr15:140,171,143...140,184,121
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit acts_upstream_of_or_within ISO (MGI:3047441|PMID:15288121) MGI PMID:15288121 MGI:3047441 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530
JBrowse link
G IER3 immediate early response 3 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:4437986|PMID:19096392) MGI
Ensembl
PMID:19096392 GO_REF:0000107 MGI:4437986 NCBI chr 7:23,265,560...23,266,905
Ensembl chr 7:23,265,564...23,266,827
JBrowse link
G MPV17L MPV17 mitochondrial inner membrane protein like involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:7,423,083...7,441,583
Ensembl chr 3:7,427,395...7,441,567
JBrowse link
G SLC25A31 solute carrier family 25 member 31 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:97,095,503...97,120,940
Ensembl chr 8:97,095,517...97,120,250
JBrowse link
G SLC25A4 solute carrier family 25 member 4 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:46,193,498...46,197,989
Ensembl chr15:46,193,746...46,200,987
JBrowse link
G SLC25A5 solute carrier family 25 member 5 involved_in IEA
IBA
(PMID:21873635) Ensembl
GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr  X:97,919,295...97,922,245
Ensembl chr  X:97,919,290...97,922,239
JBrowse link
G SLC25A6 solute carrier family 25 member 6 involved_in IBA (PMID:21873635) GO_Central PMID:21873635
G SLC35F6 solute carrier family 35 member F6 involved_in IEA UniProt
UniProt
Ensembl
GO_REF:0000104 GO_REF:0000107 NCBI chr 3:112,280,654...112,296,874
Ensembl chr 3:112,280,661...112,296,865
JBrowse link
G TMEM14A transmembrane protein 14A involved_in IBA
IEA
ISS
(PMID:21873635) GO_Central
Ensembl
UniProt
UniProt
PMID:21873635 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:46,509,724...46,517,735
Ensembl chr 7:46,509,777...46,517,732
JBrowse link
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP5IF1 ATP synthase inhibitory factor subunit 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4437986|PMID:19096392) Ensembl
Ensembl
MGI
PMID:19096392 GO_REF:0000107 MGI:4437986 NCBI chr 6:85,307,242...85,309,211
Ensembl chr 6:85,307,189...85,309,215
JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr15:140,171,134...140,184,126
Ensembl chr15:140,171,143...140,184,121
JBrowse link
G CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:49,921,600...49,923,529
Ensembl chr14:49,921,595...49,923,526
JBrowse link
G GSK3A glycogen synthase kinase 3 alpha involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 6:49,690,319...49,700,735
Ensembl chr 6:49,690,370...49,701,189
JBrowse link
G GSK3B glycogen synthase kinase 3 beta involved_in ISO (MGI:5514334|PMID:16543145) UniProt PMID:16543145 MGI:5514334 NCBI chr13:140,136,109...140,370,197
Ensembl chr13:140,136,158...140,369,569
JBrowse link
G HIP1R huntingtin interacting protein 1 related involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr14:29,996,388...30,024,343
Ensembl chr14:29,993,655...30,024,216
JBrowse link
G SIVA1 SIVA1 apoptosis inducing factor involved_in ISO (PMID:15034012) BHF-UCL PMID:15034012
G ZNF205 zinc finger protein 205 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 3:39,091,439...39,105,633
Ensembl chr 3:39,091,443...39,106,615
JBrowse link
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BBC3 BCL2 binding component 3 involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
(PMID:21873635)
(MGI:3804133|PMID:16705087)
GO_Central
Ensembl
GO_Central
MGI
PMID:16705087 PMID:21873635 GO_REF:0000107 MGI:3804133 NCBI chr 6:53,037,103...53,046,902
Ensembl chr 6:53,037,104...53,046,887
JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 acts_upstream_of_or_within ISO (MGI:2675761|PMID:12952892) MGI PMID:12952892 MGI:2675761 NCBI chr 1:161,184,458...161,188,138
Ensembl chr 1:161,182,887...161,188,164
JBrowse link
G SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 acts_upstream_of_or_within ISO (MGI:3607027|PMID:16227588) MGI PMID:16227588 MGI:3607027 NCBI chr 4:129,361,596...129,395,790
Ensembl chr 4:129,357,552...129,395,583
JBrowse link
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2675761|PMID:12952892) MGI
Ensembl
PMID:12952892 GO_REF:0000107 MGI:2675761 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
JBrowse link
G BBC3 BCL2 binding component 3 acts_upstream_of
involved_in
ISO
IEA
(MGI:3804133|PMID:16705087) MGI
Ensembl
PMID:16705087 GO_REF:0000107 MGI:3804133 NCBI chr 6:53,037,103...53,046,902
Ensembl chr 6:53,037,104...53,046,887
JBrowse link
G MOAP1 modulator of apoptosis 1 involved_in ISO (PMID:16199525) BHF-UCL PMID:16199525 NCBI chr 7:114,571,624...114,574,052 JBrowse link
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MUL1 mitochondrial E3 ubiquitin protein ligase 1 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 6:78,747,687...78,758,821
Ensembl chr 6:78,747,650...78,758,812
JBrowse link
G TMEM102 transmembrane protein 102 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr12:52,738,942...52,749,326
Ensembl chr12:52,739,238...52,741,322
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17429
    signaling 7085
      signal transduction 6584
        apoptotic signaling pathway 634
          mitochondrial outer membrane permeabilization 36
            negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 13
            positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway + 11
            protein insertion into mitochondrial membrane involved in apoptotic signaling pathway + 5
            regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway + 25
Path 2
Term Annotations click to browse term
  biological_process 17429
    cellular process 16435
      cellular component organization or biogenesis 6401
        cellular component organization 6211
          organelle organization 3520
            mitochondrion organization 572
              mitochondrial membrane organization 111
                regulation of mitochondrial membrane permeability 61
                  positive regulation of mitochondrial membrane permeability 48
                    mitochondrial outer membrane permeabilization involved in programmed cell death 45
                      positive regulation of mitochondrial membrane permeability involved in apoptotic process 43
                        mitochondrial outer membrane permeabilization 36
                          negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 13
                          positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway + 11
                          protein insertion into mitochondrial membrane involved in apoptotic signaling pathway + 5
                          regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway + 25
paths to the root