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ONTOLOGY REPORT - ANNOTATIONS


Term:mitochondrial outer membrane permeabilization
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Accession:GO:0097345 term browser browse the term
Definition:The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway.
Comment:BAX and BAK are involved in this process, as reviewed in PMID:21760595 (the human proteins have UniProt symbols Q07812 and Q16611 respectively).
Synonyms:exact_synonym: MOMP;   mitochondrion outer membrane permeabilization
 broad_synonym: mitochondrial outer membrane permeabilization during apoptotic cell death



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mitochondrial outer membrane permeabilization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BID BH3 interacting domain death agonist acts_upstream_of_or_within ISO (MGI:5566519|PMID:20436477) MGI PMID:20436477 MGI:5566519 NCBI chr27:45,344,304...45,355,735
Ensembl chr27:45,337,145...45,384,059
JBrowse link
G BLOC1S2 biogenesis of lysosomal organelles complex 1 subunit 2 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr28:13,040,016...13,044,364
Ensembl chr28:13,040,573...13,044,323
JBrowse link
G BNIP3 BCL2 interacting protein 3 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr28:40,037,681...40,050,499
Ensembl chr28:40,038,643...40,049,797
JBrowse link
G BNIP3L BCL2 interacting protein 3 like involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr25:31,133,512...31,149,750
Ensembl chr25:31,136,168...31,148,905
JBrowse link
G EYA2 EYA transcriptional coactivator and phosphatase 2 acts_upstream_of_or_within ISO (MGI:2158099|PMID:11700312) MGI PMID:11700312 MGI:2158099 NCBI chr24:34,126,086...34,308,412
Ensembl chr24:34,082,197...34,308,423
JBrowse link
G RHOT1 ras homolog family member T1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:40,715,713...40,779,551
Ensembl chr 9:40,715,941...40,779,400
JBrowse link
G RHOT2 ras homolog family member T2 involved_in ISO (PMID:12482879) UniProt PMID:12482879 NCBI chr 6:39,900,889...39,905,624
Ensembl chr 6:39,901,062...39,922,320
JBrowse link
G VDAC2 voltage dependent anion channel 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:25,449,926...25,462,147
Ensembl chr 4:25,449,442...25,462,335
JBrowse link
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAA2 acetyl-CoA acyltransferase 2 involved_in ISO (PMID:18371312) UniProt PMID:18371312 NCBI chr 7:79,028,636...79,057,720 JBrowse link
G BAK1 BCL2 antagonist/killer 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:2,950,359...2,957,604
Ensembl chr12:2,948,364...2,957,018
JBrowse link
G BCL2L1 BCL2 like 1 involved_in ISO (PMID:9393856)
(PMID:15901672), (PMID:9393856)
ComplexPortal PMID:9393856 PMID:15901672 NCBI chr24:21,145,214...21,209,425
Ensembl chr24:21,145,215...21,196,355
JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5796062|PMID:27098698) UniProt PMID:27098698 MGI:5796062 NCBI chr25:51,449,700...51,450,967 JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3047441|PMID:15288121) Ensembl
MGI
PMID:15288121 GO_REF:0000107 MGI:3047441 NCBI chr12:20,999,815...21,047,779
Ensembl chr12:21,000,792...21,047,779
JBrowse link
G HSP70 heat shock protein 70 involved_in ISO (PMID:20625543) ParkinsonsUK-UCL PMID:20625543 NCBI chr12:1,285,282...1,287,670 JBrowse link
G IER3 immediate early response 3 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:4437986|PMID:19096392) MGI
Ensembl
PMID:19096392 GO_REF:0000107 MGI:4437986 NCBI chr12:529,002...530,328
Ensembl chr12:529,339...530,232
JBrowse link
G MPV17L MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) BHF-UCL PMID:22306510 NCBI chr 6:28,385,199...28,393,560 JBrowse link
G SLC25A5 solute carrier family 25 member 5 involved_in ISO (PMID:19154410) UniProt PMID:19154410 NCBI chr  X:91,523,649...91,526,447
Ensembl chr  X:91,523,643...91,526,479
JBrowse link
G SLC35F6 solute carrier family 35 member F6 involved_in IEA UniProt
Ensembl
UniProt
GO_REF:0000104 GO_REF:0000107 NCBI chr17:20,793,821...20,807,987
Ensembl chr17:20,793,964...20,806,775
JBrowse link
G TMEM14A transmembrane protein 14A involved_in ISO (PMID:21723035) UniProt PMID:21723035 NCBI chr12:20,303,724...20,318,336 JBrowse link
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP5IF1 ATP synthase inhibitory factor subunit 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4437986|PMID:19096392) Ensembl
MGI
Ensembl
PMID:19096392 GO_REF:0000107 MGI:4437986 NCBI chr 2:72,188,562...72,191,344
Ensembl chr 2:72,188,266...72,191,326
JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5796067|PMID:26949185) UniProt PMID:26949185 MGI:5796067 NCBI chr25:51,449,700...51,450,967 JBrowse link
G CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 involved_in ISO (PMID:26666268), (PMID:30092269) UniProt PMID:26666268 PMID:30092269 NCBI chr26:28,742,466...28,744,370
Ensembl chr26:28,742,526...28,744,369
JBrowse link
G GSK3A glycogen synthase kinase 3 alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:112,129,116...112,138,714
Ensembl chr 1:112,103,825...112,138,559
JBrowse link
G GSK3B glycogen synthase kinase 3 beta involved_in ISO (MGI:5514334|PMID:16543145) UniProt PMID:16543145 MGI:5514334 NCBI chr33:23,458,369...23,659,878
Ensembl chr33:23,463,767...23,659,666
JBrowse link
G HIP1R huntingtin interacting protein 1 related involved_in ISO (PMID:19255499) ParkinsonsUK-UCL PMID:19255499 NCBI chr26:6,623,583...6,639,107
Ensembl chr26:6,624,791...6,637,659
JBrowse link
G SIVA1 SIVA1 apoptosis inducing factor involved_in ISO (PMID:15034012) BHF-UCL PMID:15034012 NCBI chr 8:72,309,400...72,313,726
Ensembl chr 8:72,309,447...72,313,640
JBrowse link
G ZNF205 zinc finger protein 205 involved_in ISO (PMID:22306510) BHF-UCL PMID:22306510 NCBI chr 6:38,085,069...38,095,012
Ensembl chr 6:38,085,231...38,097,678
JBrowse link
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BBC3 BCL2 binding component 3 involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
(PMID:21873635)
(MGI:3804133|PMID:16705087)
GO_Central
Ensembl
MGI
PMID:16705087 PMID:21873635 GO_REF:0000107 MGI:3804133 NCBI chr 1:108,742,793...108,750,832
Ensembl chr 1:108,741,713...108,749,946
JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 acts_upstream_of_or_within ISO (MGI:2675761|PMID:12952892) MGI PMID:12952892 MGI:2675761 NCBI chr 1:16,469,793...16,472,910
Ensembl chr 1:16,469,793...16,472,910
JBrowse link
G SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 acts_upstream_of_or_within ISO (MGI:3607027|PMID:16227588) MGI PMID:16227588 MGI:3607027 NCBI chr 6:61,439,414...61,471,414
Ensembl chr 6:61,439,415...61,462,087
JBrowse link
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2675761|PMID:12952892) MGI
Ensembl
PMID:12952892 GO_REF:0000107 MGI:2675761 NCBI chr 1:107,423,388...107,426,464
Ensembl chr 1:107,422,424...107,426,464
JBrowse link
G BBC3 BCL2 binding component 3 acts_upstream_of
involved_in
ISO
IEA
(MGI:3804133|PMID:16705087) MGI
Ensembl
PMID:16705087 GO_REF:0000107 MGI:3804133 NCBI chr 1:108,742,793...108,750,832
Ensembl chr 1:108,741,713...108,749,946
JBrowse link
G MOAP1 modulator of apoptosis 1 involved_in ISO (PMID:16199525) BHF-UCL PMID:16199525
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MUL1 mitochondrial E3 ubiquitin protein ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:78,394,013...78,402,032
Ensembl chr 2:78,394,040...78,425,482
JBrowse link
G TMEM102 transmembrane protein 102 involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 5:32,365,331...32,367,785
Ensembl chr 5:32,366,159...32,367,771
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17341
    signaling 6621
      signal transduction 6065
        apoptotic signaling pathway 627
          mitochondrial outer membrane permeabilization 33
            negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 11
            positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway + 11
            protein insertion into mitochondrial membrane involved in apoptotic signaling pathway + 5
            regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway + 23
Path 2
Term Annotations click to browse term
  biological_process 17341
    cellular process 16317
      cellular component organization or biogenesis 6441
        cellular component organization 6245
          organelle organization 3517
            mitochondrion organization 568
              mitochondrial membrane organization 112
                regulation of mitochondrial membrane permeability 61
                  positive regulation of mitochondrial membrane permeability 45
                    mitochondrial outer membrane permeabilization involved in programmed cell death 42
                      positive regulation of mitochondrial membrane permeability involved in apoptotic process 40
                        mitochondrial outer membrane permeabilization 33
                          negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 11
                          positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway + 11
                          protein insertion into mitochondrial membrane involved in apoptotic signaling pathway + 5
                          regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway + 23
paths to the root