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ONTOLOGY REPORT - ANNOTATIONS

Term:mitochondrial outer membrane permeabilization
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Accession:GO:0097345 term browser browse the term
Definition:The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway.
Comment:BAX and BAK are involved in this process, as reviewed in PMID:21760595 (the human proteins have UniProt symbols Q07812 and Q16611 respectively).
Synonyms:exact_synonym: MOMP;   mitochondrion outer membrane permeabilization
 broad_synonym: mitochondrial outer membrane permeabilization during apoptotic cell death


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mitochondrial outer membrane permeabilization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BID BH3 interacting domain death agonist involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20436477) Ensembl
MGI		 PMID:20436477 GO_REF:0000107 NCBI chr22:1,164,787...1,205,051
Ensembl chr22:16,594,186...16,632,844 		JBrowse link
G BLOC1S2 biogenesis of lysosomal organelles complex 1 subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:96,878,280...96,887,830
Ensembl chr10:100,358,095...100,368,640 		JBrowse link
G BNIP3 BCL2 interacting protein 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr10:128,671,663...128,685,952
Ensembl chr10:132,858,211...132,871,634 		JBrowse link
G BNIP3L BCL2 interacting protein 3 like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:25,661,629...25,685,878
Ensembl chr 8:22,567,428...22,593,004 		JBrowse link
G EYA2 EYA transcriptional coactivator and phosphatase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11700312) Ensembl
MGI		 PMID:11700312 GO_REF:0000107 NCBI chr20:43,226,621...43,520,301
Ensembl chr20:44,310,451...44,607,468 		JBrowse link
G RHOT1 ras homolog family member T1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:24,523,047...24,633,559
Ensembl chr17:24,837,093...24,917,310 		JBrowse link
G RHOT2 ras homolog family member T2 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:682,588...687,861 JBrowse link
G RTL10 retrotransposon Gag like 10 involved_in ISO (PMID:23055042) UniProt PMID:23055042 NCBI chr22:2,607,363...2,616,113 JBrowse link
G VDAC2 voltage dependent anion channel 2 involved_in ISO (PMID:31015432) UniProt PMID:31015432 NCBI chr10:71,739,395...71,763,835 JBrowse link
G VDAC2 voltage dependent anion channel 2 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr10:74,403,611...74,426,423 JBrowse link
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAA2 acetyl-CoA acyltransferase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:43,164,504...43,195,038
Ensembl chr18:46,512,374...46,542,737 		JBrowse link
G BAK1 BCL2 antagonist/killer 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:33,146,998...33,154,755
Ensembl chr 6:34,255,769...34,263,211 		JBrowse link
G BCL2L1 BCL2 like 1 involved_in ISO (PMID:15901672), (PMID:9393856) ComplexPortal PMID:9393856 PMID:15901672 NCBI chr20:27,955,688...28,015,950
Ensembl chr20:29,088,055...29,146,585 		JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:128,832,458...128,847,918
Ensembl chr2B:247,626,494...247,640,238 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15288121) Ensembl
MGI		 PMID:15288121 GO_REF:0000107 NCBI chr 6:53,052,145...53,102,794
Ensembl chr 6:54,687,315...54,734,994 		JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A involved_in ISO (PMID:20625543) ParkinsonsUK-UCL PMID:20625543 NCBI chr 6:31,476,710...31,491,411 JBrowse link
G HSPA1B heat shock protein family A (Hsp70) member 1B involved_in ISO (PMID:20625543) ParkinsonsUK-UCL PMID:20625543 NCBI chr 6:31,488,882...31,491,412 JBrowse link
G IER3 immediate early response 3 acts_upstream_of_or_within ISO (PMID:19096392) MGI PMID:19096392 NCBI chr 6:30,488,162...30,489,784 JBrowse link
G LOC129395394 ADP/ATP translocase 3 involved_in IEA TreeGrafter GO_REF:0000118
G MPV17L MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) BHF-UCL PMID:22306510
G SLC25A4 solute carrier family 25 member 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 4:177,310,982...177,315,016
Ensembl chr 4:189,531,914...189,534,549 		JBrowse link
G SLC25A5 solute carrier family 25 member 5 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:108,501,654...108,504,591
Ensembl chr  X:118,926,743...118,929,624 		JBrowse link
G SLC35F6 solute carrier family 35 member F6 involved_in IEA UniProt
Ensembl		 GO_REF:0000104 GO_REF:0000107 NCBI chr2A:26,762,690...26,780,492
Ensembl chr2A:26,854,078...26,871,820 		JBrowse link
G TMEM14A transmembrane protein 14A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:52,226,416...52,241,846
Ensembl chr 6:53,492,943...53,508,340 		JBrowse link
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP5IF1 ATP synthase inhibitory factor subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19096392) Ensembl
MGI		 PMID:19096392 GO_REF:0000107 NCBI chr 1:27,495,250...27,497,255
Ensembl chr 1:28,532,091...28,542,607 		JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:128,832,458...128,847,918
Ensembl chr2B:247,626,494...247,640,238 		JBrowse link
G CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 involved_in ISO (PMID:26666268), (PMID:30092269) UniProt PMID:26666268 PMID:30092269 NCBI chr22:4,521,604...4,523,740 JBrowse link
G GSK3A glycogen synthase kinase 3 alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:39,118,330...39,130,768
Ensembl chr19:47,710,197...47,726,948 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta involved_in ISO (MGI:5514334|PMID:16543145) UniProt PMID:16543145 MGI:5514334 NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771 		JBrowse link
G HIP1R huntingtin interacting protein 1 related involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:120,438,841...120,467,489
Ensembl chr12:124,685,091...124,700,726 		JBrowse link
G SIVA1 SIVA1 apoptosis inducing factor involved_in ISO (PMID:15034012) BHF-UCL PMID:15034012 NCBI chr14:85,404,148...85,408,254
Ensembl chr14:105,196,118...105,202,678 		JBrowse link
G ZNF205 zinc finger protein 205 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:2,054,056...2,061,992
Ensembl chr16:3,233,794...3,241,216 		JBrowse link
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MUL1 mitochondrial E3 ubiquitin protein ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:19,454,792...19,463,527
Ensembl chr 1:20,496,356...20,505,281 		JBrowse link
G TMEM102 transmembrane protein 102 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:7,469,096...7,471,645
Ensembl chr17:7,455,716...7,457,947 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16440
    cellular process 15499
      signal transduction 5440
        apoptotic signaling pathway 644
          mitochondrial outer membrane permeabilization 33
            negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 14
            positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 8
            regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway + 23
Path 2
Term Annotations click to browse term
  biological_process 16440
    cellular process 15499
      cellular component organization or biogenesis 6620
        cellular component organization 6401
          organelle organization 3612
            mitochondrion organization 529
              mitochondrial membrane organization 110
                regulation of mitochondrial membrane permeability 58
                  positive regulation of mitochondrial membrane permeability 42
                    mitochondrial outer membrane permeabilization involved in programmed cell death 39
                      positive regulation of mitochondrial membrane permeability involved in apoptotic process 37
                        mitochondrial outer membrane permeabilization 33
                          negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 14
                          positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 8
                          regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway + 23
paths to the root