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ONTOLOGY REPORT - ANNOTATIONS


Term:ripoptosome
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Accession:GO:0097342 term browser browse the term
Definition:A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more.
Comment:It has been shown that receptor-mediated necroptotic signaling pathway requires assembly of a ripoptosome protein complex consisting of caspase-8, caspase-10, Fas-associated death domain protein (FADD), casp8 and FADD-like apoptosis regulator (CFLAR) as well as the two receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (PMID:21737330). Optionally, depending on the receptor activated, this complex may contain TLR3 adaptor protein TRIF (PMID:21737330).
Synonyms:narrow_synonym: TNFR1 complex II;   Tnfr1-CII
 related_synonym: necrosome


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ripoptosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp8 caspase 8 part_of ISO
ISS
(PMID:21737330)
GO_REF:0000024
RGD
UniProt
PMID:21737330 GO_REF:0000024 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator part_of ISO (PMID:21737330) RGD PMID:21737330 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Fadd Fas associated via death domain part_of ISO
ISS
(PMID:21737330)
GO_REF:0000024
RGD
UniProt
PMID:21737330 GO_REF:0000024 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 part_of ISO
ISS
(PMID:21737330)
GO_REF:0000024
RGD
UniProt
PMID:21737330 GO_REF:0000024 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Ticam1 toll-like receptor adaptor molecule 1 part_of ISO (PMID:21737330) RGD PMID:21737330 NCBI chr 9:10,780,185...10,790,280 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20126
    cellular anatomical entity 19825
      cytosol 4232
        ripoptosome 5
Path 2
Term Annotations click to browse term
  cellular_component 20126
    cellular anatomical entity 19825
      intracellular anatomical structure 14390
        cytoplasm 11380
          cytosol 4232
            ripoptosome 5
paths to the root