Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:ripoptosome
go back to main search page
Accession:GO:0097342 term browser browse the term
Definition:A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more.
Comment:It has been shown that receptor-mediated necroptotic signaling pathway requires assembly of a ripoptosome protein complex consisting of caspase-8, caspase-10, Fas-associated death domain protein (FADD), casp8 and FADD-like apoptosis regulator (CFLAR) as well as the two receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (PMID:21737330). Optionally, depending on the receptor activated, this complex may contain TLR3 adaptor protein TRIF (PMID:21737330).
Synonyms:narrow_synonym: TNFR1 complex II;   Tnfr1-CII
 related_synonym: necrosome


show annotations for term's descendants           Sort by:
ripoptosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp8 caspase 8 part_of ISO
ISS		 (PMID:21737330)
GO_REF:0000024		 RGD
UniProt		 PMID:21737330 GO_REF:0000024 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator part_of ISO (PMID:21737330) RGD PMID:21737330 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Fadd Fas associated via death domain part_of ISO
ISS		 (PMID:21737330)
GO_REF:0000024		 RGD
UniProt		 PMID:21737330 GO_REF:0000024 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 part_of ISO
ISS		 (PMID:21737330)
GO_REF:0000024		 RGD
UniProt		 PMID:21737330 GO_REF:0000024 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 part_of ISO (PMID:21737330) RGD PMID:21737330 NCBI chr 9:1,102,559...1,115,573
Ensembl chr 9:1,102,366...1,123,147 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20183
    cellular anatomical entity 20022
      cytosol 4120
        ripoptosome 5
Path 2
Term Annotations click to browse term
  cellular_component 20183
    cellular anatomical entity 20022
      intracellular anatomical structure 14612
        cytoplasm 11433
          cytosol 4120
            ripoptosome 5
paths to the root