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Term:R2TP complex
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Accession:GO:0097255 term browser browse the term
Definition:A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.

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R2TP complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pih1d1 PIH1 domain containing 1 part_of IBA
(PMID:21078300), (PMID:26711270)
RGD PMID:21078300 PMID:26711270, PMID:21873635 RGD:13792537 NCBI chr 1:101,151,240...101,156,806
Ensembl chr 1:101,152,734...101,156,805
JBrowse link
G Pih1d2 PIH1 domain containing 2 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:55,050,284...55,060,289
Ensembl chr 8:55,050,284...55,058,474
JBrowse link
G RGD1564855 similar to RuvB-like protein 1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:1,854,580...1,856,333
Ensembl chr  X:1,854,751...1,856,258
JBrowse link
G Rpap3 RNA polymerase II associated protein 3 part_of ISO (PMID:26711270) RGD PMID:26711270 NCBI chr 7:139,167,302...139,196,468
Ensembl chr 7:139,167,303...139,196,416
JBrowse link
G Ruvbl1 RuvB-like AAA ATPase 1 part_of IBA
(PMID:26711270), (PMID:33367824)
PMID:26711270 PMID:33367824, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 4:120,411,917...120,447,458
Ensembl chr 4:120,411,991...120,447,455
JBrowse link
G Ruvbl2 RuvB-like AAA ATPase 2 part_of IBA
(PMID:26711270), (PMID:33367824)
RGD PMID:26711270 PMID:33367824, PMID:21873635 RGD:13792537 NCBI chr 1:101,413,766...101,426,970
Ensembl chr 1:101,413,766...101,426,852
JBrowse link

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  cellular_component 20142
    protein-containing complex 6031
      R2TP complex 6
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