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ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid-beta clearance
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Accession:GO:0097242 term browser browse the term
Definition:The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.

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amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in ISO (PMID:22438044)
(PMID:20199584)		 ARUK-UCL PMID:20199584 PMID:22438044 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G C5ar1 complement C5a receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936664:1,026,216...1,033,438
Ensembl chrNW_004936664:1,032,304...1,033,374 		JBrowse link
G Clu clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936675:499,745...513,515
Ensembl chrNW_004936675:499,199...513,836 		JBrowse link
G Ide insulin degrading enzyme involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26637123) Ensembl
MGI		 PMID:26637123 GO_REF:0000107 NCBI chrNW_004936601:2,230,477...2,318,562
Ensembl chrNW_004936601:2,230,283...2,318,752 		JBrowse link
G Igf1r insulin like growth factor 1 receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936483:4,563,995...4,860,231
Ensembl chrNW_004936483:4,564,512...4,852,925 		JBrowse link
G Insr insulin receptor involved_in ISO PMID:19406747 ARUK-UCL PMID:19406747 RGD:13210538 NCBI chrNW_004936588:4,345,306...4,453,380
Ensembl chrNW_004936588:4,345,306...4,453,668 		JBrowse link
G Itgam integrin subunit alpha M involved_in ISO (PMID:20199584)
(PMID:22438044)		 ARUK-UCL PMID:20199584 PMID:22438044 NCBI chrNW_004936543:8,460,526...8,508,524
Ensembl chrNW_004936543:8,461,307...8,508,524 		JBrowse link
G Itgb2 integrin subunit beta 2 involved_in ISO (PMID:20199584) ARUK-UCL PMID:20199584 NCBI chrNW_004936778:1,286,475...1,311,184
Ensembl chrNW_004936778:1,286,341...1,311,194 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936659:1,259,405...1,300,545
Ensembl chrNW_004936659:1,259,369...1,302,294 		JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO (PMID:19098903) BHF-UCL PMID:19098903 NCBI chrNW_004936646:1,326,900...1,407,236
Ensembl chrNW_004936646:1,327,374...1,406,456 		JBrowse link
G Lrp2 LDL receptor related protein 2 involved_in ISO PMID:16306401 ARUK-UCL PMID:16306401 RGD:14697713 NCBI chrNW_004936469:10,245,001...10,438,933
Ensembl chrNW_004936469:10,244,881...10,438,935 		JBrowse link
G Marco macrophage receptor with collagenous structure involved_in ISO PMID:15987691 ARUK-UCL PMID:15987691 RGD:13432286 NCBI chrNW_004936469:51,323,746...51,366,551 JBrowse link
G Mme membrane metalloendopeptidase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936519:2,513,896...2,595,896
Ensembl chrNW_004936519:2,513,704...2,595,971 		JBrowse link
G Msr1 macrophage scavenger receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936573:5,345,282...5,391,946
Ensembl chrNW_004936573:5,328,526...5,388,901 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936780:1,553,605...1,601,036
Ensembl chrNW_004936780:1,553,605...1,598,158 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:18,659,725...18,665,406
Ensembl chrNW_004936476:18,659,815...18,663,940 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor TYROBP involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936570:457,993...460,735
Ensembl chrNW_004936570:458,054...460,579 		JBrowse link
amyloid-beta clearance by cellular catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:27472885) UniProt PMID:27472885 NCBI chrNW_004936588:460,308...477,382
Ensembl chrNW_004936588:461,389...477,229 		JBrowse link
G Cd36 CD36 molecule (CD36 blood group) involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936810:791,823...838,303
Ensembl chrNW_004936810:758,182...838,365 		JBrowse link
G Ide insulin degrading enzyme involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936601:2,230,477...2,318,562
Ensembl chrNW_004936601:2,230,283...2,318,752 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936659:1,259,405...1,300,545
Ensembl chrNW_004936659:1,259,369...1,302,294 		JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936646:1,326,900...1,407,236
Ensembl chrNW_004936646:1,327,374...1,406,456 		JBrowse link
G Lrp4 LDL receptor related protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936562:2,211,519...2,262,899
Ensembl chrNW_004936562:2,211,514...2,263,937 		JBrowse link
G Mme membrane metalloendopeptidase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936519:2,513,896...2,595,896
Ensembl chrNW_004936519:2,513,704...2,595,971 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:18,659,725...18,665,406
Ensembl chrNW_004936476:18,659,815...18,663,940 		JBrowse link
amyloid-beta clearance by transcytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cltc clathrin heavy chain involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:3,659,682...3,726,222
Ensembl chrNW_004936490:3,657,242...3,726,274 		JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936646:1,326,900...1,407,236
Ensembl chrNW_004936646:1,327,374...1,406,456 		JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936477:20,234,582...20,250,756
Ensembl chrNW_004936477:20,234,533...20,250,751 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936498:13,785,638...13,885,931
Ensembl chrNW_004936498:13,784,886...13,886,167 		JBrowse link
G Rab11a RAB11A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:26,089,216...26,111,245
Ensembl chrNW_004936471:26,088,852...26,113,433 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936588:5,198,659...5,210,430
Ensembl chrNW_004936588:5,198,394...5,214,603 		JBrowse link
G Rab5a RAB5A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:12,238,226...12,267,339
Ensembl chrNW_004936473:12,238,156...12,269,089 		JBrowse link
negative regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936549:1,378,536...1,400,501
Ensembl chrNW_004936549:1,378,736...1,400,532 		JBrowse link
G Ifng interferon gamma involved_in ISO (PMID:29061364)
(PMID:17255335)		 ARUK-UCL PMID:17255335 PMID:29061364 NCBI chrNW_004936545:6,139,130...6,144,543
Ensembl chrNW_004936545:6,139,116...6,148,452 		JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO (PMID:17255335) ARUK-UCL PMID:17255335 NCBI chrNW_004936560:4,519,858...4,545,763
Ensembl chrNW_004936560:4,519,474...4,545,796 		JBrowse link
G LOC101955024 lanosterol 14-alpha demethylase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936621:2,209,255...2,232,404
Ensembl chrNW_004936621:2,209,199...2,232,531 		JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936477:20,234,582...20,250,756
Ensembl chrNW_004936477:20,234,533...20,250,751 		JBrowse link
G Myocd myocardin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936595:5,256,615...5,356,563
Ensembl chrNW_004936595:5,256,785...5,351,723 		JBrowse link
G Pla2g3 phospholipase A2 group III involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26637123) Ensembl
MGI		 PMID:26637123 GO_REF:0000107 NCBI chrNW_004936755:307,166...312,683
Ensembl chrNW_004936755:306,313...312,683 		JBrowse link
G Srf serum response factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:16,779,941...16,789,499
Ensembl chrNW_004936476:16,782,233...16,789,130 		JBrowse link
G Tnf tumor necrosis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766 		JBrowse link
positive regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:23467355) Alzheimers_University_of_Toronto PMID:23467355 NCBI chrNW_004936588:460,308...477,382
Ensembl chrNW_004936588:461,389...477,229 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:14741101) UniProt PMID:14741101 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO (PMID:26619118) ARUK-UCL PMID:26619118 NCBI chrNW_004936646:1,326,900...1,407,236
Ensembl chrNW_004936646:1,327,374...1,406,456 		JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936550:730,462...874,601
Ensembl chrNW_004936550:733,239...874,601 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:18,659,725...18,665,406
Ensembl chrNW_004936476:18,659,815...18,663,940 		JBrowse link
G Ttpa alpha tocopherol transfer protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26637123) Ensembl
MGI		 PMID:26637123 GO_REF:0000107 NCBI chrNW_004936496:10,409,948...10,466,722
Ensembl chrNW_004936496:10,454,605...10,465,301 		JBrowse link
regulation of amyloid-beta clearance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISO (PMID:24446231) Alzheimers_University_of_Toronto PMID:24446231 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G App amyloid beta precursor protein acts_upstream_of ISO (PMID:19057576) ARUK-UCL PMID:19057576 NCBI chrNW_004936640:1,549,977...1,787,436
Ensembl chrNW_004936640:1,550,167...1,787,286 		JBrowse link
G Clu clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936675:499,745...513,515
Ensembl chrNW_004936675:499,199...513,836 		JBrowse link
Term paths to the root